Q8IXJ6 | SIR2_HUMAN | NAD-dependent protein deacetylase sirtuin-2 (SIRT2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF02146 | SIR2 - Sir2 family | 84~268 |
3D structures mapped by conservation among orthologs
[ Domain: "DHS-like NAD/FAD-binding domain" // SIR2_1st ]
[ Domain: "Rubredoxin-related" // SIR2_2nd ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2338810 |  |
IC50 | = | 1.1 | nM | 383.5 | CS(=O)(=O)NCCC1CCN(c2ncnc3cc(C(N)=O)sc23)CC1 | Homo sapiens | CHEMBL2341151 | single protein format |
| CHEMBL2332037 |  |
IC50 | = | 1.3 | nM | 480.59 | CCNC(=O)c1cccc(C(=O)NCCC2CCN(c3ncnc4cc(C(N)=O)sc34)CC2)c1 | Homo sapiens | CHEMBL2341151 | single protein format |
| CHEMBL2332041 |  |
IC50 | = | 1.8 | nM | 515.66 | CC(C)(C)OC(=O)c1ccc(C(=O)NCCC2CCN(c3ncnc4cc(C(N)=O)sc34)CC2)s1 | Homo sapiens | CHEMBL2341151 | single protein format |
| CHEMBL2332039 |  |
IC50 | = | 2.7 | nM | 486.62 | CCNC(=O)c1ccc(C(=O)NCCC2CCN(c3ncnc4cc(C(N)=O)sc34)CC2)s1 | Homo sapiens | CHEMBL2341151 | single protein format |
| CHEMBL2332042 |  |
IC50 | = | 4.4 | nM | 459.55 | NC(=O)c1cc2ncnc(N3CCC(CCNC(=O)c4ccc(C(=O)O)s4)CC3)c2s1 | Homo sapiens | CHEMBL2341151 | single protein format |
| CHEMBL2332040 |  |
IC50 | = | 4.8 | nM | 487.61 | CCNC(=O)c1ccc(C(=O)NCCN2CCN(c3ncnc4cc(C(N)=O)sc34)CC2)s1 | Homo sapiens | CHEMBL2341151 | single protein format |
| CHEMBL2332044 |  |
IC50 | = | 5.4 | nM | 405.52 | CC(C)(C)OC(=O)NCCC1CCN(c2ncnc3cc(C(N)=O)sc23)CC1 | Homo sapiens | CHEMBL2341151 | single protein format |
| CHEMBL2332043 |  |
IC50 | = | 6.5 | nM | 415.54 | NC(=O)c1cc2ncnc(N3CCC(CCNC(=O)c4cccs4)CC3)c2s1 | Homo sapiens | CHEMBL2341151 | single protein format |
| CHEMBL2332038 |  |
IC50 | = | 10.0 | nM | 481.58 | CCNC(=O)c1cccc(C(=O)NCCN2CCN(c3ncnc4cc(C(N)=O)sc34)CC2)c1 | Homo sapiens | CHEMBL2341151 | single protein format |
| CHEMBL2332055 |  |
IC50 | = | 10.0 | nM | 389.53 | CC(C)(C)C(=O)NCCC1CCN(c2ncnc3cc(C(N)=O)sc23)CC1 | Homo sapiens | CHEMBL2341151 | single protein format |
| CHEMBL3805001 |  |
IC50 | = | 13.5 | nM | 423.47 | NC(=O)c1cncc(OCc2cccc(NC(=O)c3ccc(-c4ccccc4)cc3)c2)c1 | Homo sapiens | CHEMBL3806935 | assay format |
| CHEMBL3805929 |  |
IC50 | = | 15.7 | nM | 387.4 | NC(=O)c1cncc(OCc2cccc(NC(=O)c3ccc4cn[nH]c4c3)c2)c1 | Homo sapiens | CHEMBL3806935 | assay format |
| CHEMBL2338808 |  |
IC50 | = | 16.0 | nM | 403.55 | CC(C)(C)C(=O)NCCCC1CCN(c2ncnc3cc(C(N)=O)sc23)CC1 | Homo sapiens | CHEMBL2341151 | single protein format |
| CHEMBL3805692 |  |
IC50 | = | 16.7 | nM | 432.48 | NC(=O)c1cncc(OCc2cccc(NC(=O)c3ccc(N4CCOCC4)cc3)c2)c1 | Homo sapiens | CHEMBL3806935 | assay format |
| CHEMBL2338809 |  |
IC50 | = | 17.0 | nM | 390.51 | CC(C)(C)C(=O)NCCN1CCN(c2ncnc3cc(C(N)=O)sc23)CC1 | Homo sapiens | CHEMBL2341151 | single protein format |
| CHEMBL3804834 |  |
IC50 | = | 19.0 | nM | 414.43 | NC(=O)c1cncc(OCc2cccc(NC(=O)c3ccc(-n4cnnc4)cc3)c2)c1 | Homo sapiens | CHEMBL3806935 | assay format |
| CHEMBL4638983 |  |
IC50 | = | 20.0 | nM | 581.87 | CCCCCCCCCCCCCC(=S)NCCCCC(NC(=O)OCc1ccccc1)C(=O)Nc1ccccc1 | Homo sapiens | CHEMBL4613334 | single protein format |
| CHEMBL3805063 |  |
IC50 | = | 22.4 | nM | 413.44 | NC(=O)c1cncc(OCc2cccc(NC(=O)c3ccc(-n4cccc4)nc3)c2)c1 | Homo sapiens | CHEMBL3806935 | assay format |
| CHEMBL3805835 |  |
IC50 | = | 22.7 | nM | 424.46 | NC(=O)c1cncc(OCc2cccc(NC(=O)c3ccc(-c4ccccn4)cc3)c2)c1 | Homo sapiens | CHEMBL3806935 | assay format |
| CHEMBL3806268 |  |
IC50 | = | 22.9 | nM | 424.46 | NC(=O)c1cncc(OCc2cccc(NC(=O)c3ccc(-c4ccncc4)cc3)c2)c1 | Homo sapiens | CHEMBL3806935 | assay format |