Q8IWU9 | TPH2_HUMAN | Tryptophan 5-hydroxylase 2 (TPH2)
Helixβ‑strandTurn secondary structure
Pfam Domain Table
Accession | Domain | Range | Color |
---|---|---|---|
PF00351 | Biopterin_H | 152–481 |
3D structures mapped by conservation among orthologs
[ Domain: "Aromatic aminoacid monoxygenases, catalytic and oligomerization domains" // Biopterin_H ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
---|---|---|---|---|---|---|---|---|---|---|
CHEMBL5395489 | IC50 | = | 11.0 | nM | 406.47 | CCn1c(=O)[nH]c(=O)c2c1nc(Cc1cn3ccsc3n1)n2Cc1ccccc1 | Homo sapiens | CHEMBL5374997 | single protein format | |
CHEMBL5191481 | IC50 | = | 14.0 | nM | 444.45 | CCn1c(=O)[nH]c(=O)c2c1nc(Cc1nc3cc4c(cc3[nH]1)OCO4)n2Cc1ccccc1 | Homo sapiens | CHEMBL5141807 | single protein format | |
CHEMBL5173430 | IC50 | = | 14.0 | nM | 458.48 | CCCn1c(=O)[nH]c(=O)c2c1nc(Cc1nc3cc4c(cc3[nH]1)OCO4)n2Cc1ccccc1 | Homo sapiens | CHEMBL5141807 | single protein format | |
CHEMBL5416480 | IC50 | = | 14.0 | nM | 486.56 | CCn1c(=O)[nH]c(=O)c2c1nc(Cc1cn3ccsc3n1)n2Cc1ccc(-c2ccn(C)n2)cc1 | Homo sapiens | CHEMBL5374997 | single protein format | |
CHEMBL5424626 | IC50 | = | 15.0 | nM | 440.92 | CCn1c(=O)[nH]c(=O)c2c1nc(Cc1cn3cc(Cl)sc3n1)n2Cc1ccccc1 | Homo sapiens | CHEMBL5374997 | single protein format | |
CHEMBL5397485 | IC50 | = | 16.0 | nM | 420.5 | CCn1c(=O)[nH]c(=O)c2c1nc(Cc1cn3cc(C)sc3n1)n2Cc1ccccc1 | Homo sapiens | CHEMBL5374997 | single protein format | |
CHEMBL5407430 | IC50 | = | 16.0 | nM | 477.55 | CCn1c(=O)[nH]c(=O)c2c1nc(Cc1cn3cc(C)sc3n1)n2Cc1ccc(NC(C)=O)cc1 | Homo sapiens | CHEMBL5374997 | single protein format | |
CHEMBL5404510 | IC50 | = | 16.0 | nM | 400.46 | CCn1c(=O)[nH]c(=O)c2c1nc(Cc1cn3cc(C)sc3n1)n2CC1COC1 | Homo sapiens | CHEMBL5374997 | single protein format | |
CHEMBL5423163 | IC50 | = | 17.0 | nM | 503.59 | CCn1c(=O)[nH]c(=O)c2c1nc(Cc1cn3cc(C)sc3n1)n2Cc1ccc(N2CCCC2=O)cc1 | Homo sapiens | CHEMBL5374997 | single protein format | |
CHEMBL5420432 | IC50 | = | 17.0 | nM | 480.53 | CCn1c(=O)[nH]c(=O)c2c1nc(Cc1cn3ccccc3n1)n2Cc1ccc(-c2ccn(C)n2)cc1 | Homo sapiens | CHEMBL5374997 | single protein format | |
CHEMBL5394253 | IC50 | = | 17.0 | nM | 497.97 | CCn1c(=O)[nH]c(=O)c2c1nc(Cc1cn3cc(Cl)sc3n1)n2Cc1ccc(NC(C)=O)cc1 | Homo sapiens | CHEMBL5374997 | single protein format | |
CHEMBL5435460 | IC50 | = | 17.0 | nM | 483.56 | CCn1c(=O)[nH]c(=O)c2c1nc(Cc1cn3ccccc3n1)n2Cc1ccc(-c2nccs2)cc1 | Homo sapiens | CHEMBL5374997 | single protein format | |
CHEMBL5438308 | IC50 | = | 18.0 | nM | 421.49 | CCn1c(=O)[nH]c(=O)c2c1nc(Cc1cn3cc(C)sc3n1)n2Cc1ccccn1 | Homo sapiens | CHEMBL5374997 | single protein format | |
CHEMBL5438521 | IC50 | = | 18.0 | nM | 482.5 | CCn1c(=O)[nH]c(=O)c2c1nc(Cc1cn3ccccc3n1)n2Cc1ccc(-c2noc(C)n2)cc1 | Homo sapiens | CHEMBL5374997 | single protein format | |
CHEMBL5408595 | IC50 | = | 18.0 | nM | 421.49 | CCn1c(=O)[nH]c(=O)c2c1nc(Cc1cn3nc(C)sc3n1)n2Cc1ccccc1 | Homo sapiens | CHEMBL5374997 | single protein format | |
CHEMBL5169479 | IC50 | = | 19.0 | nM | 400.44 | CCn1c(=O)[nH]c(=O)c2c1nc(Cc1nc3ccccc3[nH]1)n2Cc1ccccc1 | Homo sapiens | CHEMBL5141807 | single protein format | |
CHEMBL5203888 | IC50 | = | 20.0 | nM | 414.47 | CCCn1c(=O)[nH]c(=O)c2c1nc(Cc1nc3ccccc3[nH]1)n2Cc1ccccc1 | Homo sapiens | CHEMBL5141807 | single protein format | |
CHEMBL5421387 | IC50 | = | 20.0 | nM | 458.48 | CCn1c(=O)[nH]c(=O)c2c1nc(Cc1cn3ccccc3n1)n2Cc1ccc(C(=O)OC)cc1 | Homo sapiens | CHEMBL5374997 | single protein format | |
CHEMBL5413997 | IC50 | = | 20.0 | nM | 482.5 | CCn1c(=O)[nH]c(=O)c2c1nc(Cc1cn3ccccc3n1)n2Cc1ccc(-c2nc(C)no2)cc1 | Homo sapiens | CHEMBL5374997 | single protein format | |
CHEMBL5172829 | IC50 | = | 20.0 | nM | 444.5 | CCOc1ccc2[nH]c(Cc3nc4c(c(=O)[nH]c(=O)n4CC)n3Cc3ccccc3)nc2c1 | Homo sapiens | CHEMBL5141807 | single protein format |