Q8IWU9 | TPH2_HUMAN | Tryptophan 5-hydroxylase 2 (TPH2)

Helixβ‑strandTurn secondary structure

Pfam Domain Table

AccessionDomainRangeColor
PF00351Biopterin_H152–481

 3D structures mapped by conservation among orthologs

[ Domain: "Aromatic aminoacid monoxygenases, catalytic and oligomerization domains" // Biopterin_H ]

 PyMOL session


 [ Alpha Fold Model ] (go)



 Known binders annotated in ChEMBL

 IC50 CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL5395489 IC50 = 11.0 nM 406.47 CCn1c(=O)[nH]c(=O)c2c1nc(Cc1cn3ccsc3n1)n2Cc1ccccc1 Homo sapiens CHEMBL5374997 single protein format
CHEMBL5191481 IC50 = 14.0 nM 444.45 CCn1c(=O)[nH]c(=O)c2c1nc(Cc1nc3cc4c(cc3[nH]1)OCO4)n2Cc1ccccc1 Homo sapiens CHEMBL5141807 single protein format
CHEMBL5173430 IC50 = 14.0 nM 458.48 CCCn1c(=O)[nH]c(=O)c2c1nc(Cc1nc3cc4c(cc3[nH]1)OCO4)n2Cc1ccccc1 Homo sapiens CHEMBL5141807 single protein format
CHEMBL5416480 IC50 = 14.0 nM 486.56 CCn1c(=O)[nH]c(=O)c2c1nc(Cc1cn3ccsc3n1)n2Cc1ccc(-c2ccn(C)n2)cc1 Homo sapiens CHEMBL5374997 single protein format
CHEMBL5424626 IC50 = 15.0 nM 440.92 CCn1c(=O)[nH]c(=O)c2c1nc(Cc1cn3cc(Cl)sc3n1)n2Cc1ccccc1 Homo sapiens CHEMBL5374997 single protein format
CHEMBL5397485 IC50 = 16.0 nM 420.5 CCn1c(=O)[nH]c(=O)c2c1nc(Cc1cn3cc(C)sc3n1)n2Cc1ccccc1 Homo sapiens CHEMBL5374997 single protein format
CHEMBL5407430 IC50 = 16.0 nM 477.55 CCn1c(=O)[nH]c(=O)c2c1nc(Cc1cn3cc(C)sc3n1)n2Cc1ccc(NC(C)=O)cc1 Homo sapiens CHEMBL5374997 single protein format
CHEMBL5404510 IC50 = 16.0 nM 400.46 CCn1c(=O)[nH]c(=O)c2c1nc(Cc1cn3cc(C)sc3n1)n2CC1COC1 Homo sapiens CHEMBL5374997 single protein format
CHEMBL5423163 IC50 = 17.0 nM 503.59 CCn1c(=O)[nH]c(=O)c2c1nc(Cc1cn3cc(C)sc3n1)n2Cc1ccc(N2CCCC2=O)cc1 Homo sapiens CHEMBL5374997 single protein format
CHEMBL5420432 IC50 = 17.0 nM 480.53 CCn1c(=O)[nH]c(=O)c2c1nc(Cc1cn3ccccc3n1)n2Cc1ccc(-c2ccn(C)n2)cc1 Homo sapiens CHEMBL5374997 single protein format
CHEMBL5394253 IC50 = 17.0 nM 497.97 CCn1c(=O)[nH]c(=O)c2c1nc(Cc1cn3cc(Cl)sc3n1)n2Cc1ccc(NC(C)=O)cc1 Homo sapiens CHEMBL5374997 single protein format
CHEMBL5435460 IC50 = 17.0 nM 483.56 CCn1c(=O)[nH]c(=O)c2c1nc(Cc1cn3ccccc3n1)n2Cc1ccc(-c2nccs2)cc1 Homo sapiens CHEMBL5374997 single protein format
CHEMBL5438308 IC50 = 18.0 nM 421.49 CCn1c(=O)[nH]c(=O)c2c1nc(Cc1cn3cc(C)sc3n1)n2Cc1ccccn1 Homo sapiens CHEMBL5374997 single protein format
CHEMBL5438521 IC50 = 18.0 nM 482.5 CCn1c(=O)[nH]c(=O)c2c1nc(Cc1cn3ccccc3n1)n2Cc1ccc(-c2noc(C)n2)cc1 Homo sapiens CHEMBL5374997 single protein format
CHEMBL5408595 IC50 = 18.0 nM 421.49 CCn1c(=O)[nH]c(=O)c2c1nc(Cc1cn3nc(C)sc3n1)n2Cc1ccccc1 Homo sapiens CHEMBL5374997 single protein format
CHEMBL5169479 IC50 = 19.0 nM 400.44 CCn1c(=O)[nH]c(=O)c2c1nc(Cc1nc3ccccc3[nH]1)n2Cc1ccccc1 Homo sapiens CHEMBL5141807 single protein format
CHEMBL5203888 IC50 = 20.0 nM 414.47 CCCn1c(=O)[nH]c(=O)c2c1nc(Cc1nc3ccccc3[nH]1)n2Cc1ccccc1 Homo sapiens CHEMBL5141807 single protein format
CHEMBL5421387 IC50 = 20.0 nM 458.48 CCn1c(=O)[nH]c(=O)c2c1nc(Cc1cn3ccccc3n1)n2Cc1ccc(C(=O)OC)cc1 Homo sapiens CHEMBL5374997 single protein format
CHEMBL5413997 IC50 = 20.0 nM 482.5 CCn1c(=O)[nH]c(=O)c2c1nc(Cc1cn3ccccc3n1)n2Cc1ccc(-c2nc(C)no2)cc1 Homo sapiens CHEMBL5374997 single protein format
CHEMBL5172829 IC50 = 20.0 nM 444.5 CCOc1ccc2[nH]c(Cc3nc4c(c(=O)[nH]c(=O)n4CC)n3Cc3ccccc3)nc2c1 Homo sapiens CHEMBL5141807 single protein format