Q8IVH8 | M4K3_HUMAN | Mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 16~273 | |
| PF00780 | CNH - CNH domain | 572~860 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL388978 |  |
IC50 | = | 0.0825 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328431 | single protein format |
| CHEMBL4780798 |  |
IC50 | = | 0.46 | nM | 567.65 | CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nc(C56CCN(CC5)CC6)no4)c(N[C@H](CO)c4ccccc4)n3)cc21 | Homo sapiens | CHEMBL4689492 | single protein format |
| CHEMBL5428695 |  |
IC50 | = | 0.8 | nM | 439.52 | Cc1c(-c2ccc3cnc(Nc4ccc5c(c4)C(C)(C)OC5)nc3c2)cnc2c1NCCO2 | Homo sapiens | CHEMBL5328406 | single protein format |
| CHEMBL4778959 |  |
IC50 | = | 1.5 | nM | 555.64 | CN1CCC(c2noc(-c3cnc(Nc4ccc5c(c4)C(C)(C)OC5=O)nc3N[C@H](CO)c3ccccc3)n2)CC1 | Homo sapiens | CHEMBL4689492 | single protein format |
| CHEMBL5396693 |  |
IC50 | = | 3.0 | nM | 398.51 | CN1CCC(c2ccc(Nc3ncc4ccc(-c5cnn(C)c5)cc4n3)cc2)CC1 | Homo sapiens | CHEMBL5328406 | single protein format |
| CHEMBL4762312 |  |
IC50 | = | 5.0 | nM | 446.31 | Nc1ncc(-c2cnn(C3CCNCC3)c2)c2cc(-c3c(Cl)ccc(F)c3Cl)oc12 | Homo sapiens | CHEMBL4674513 | single protein format |
| CHEMBL5397290 |  |
IC50 | = | 7.0 | nM | 378.87 | N#Cc1cccc(-c2c(Cl)[nH]c3ncnc(N4CCC[C@H]5NCC[C@H]54)c23)c1 | Homo sapiens | CHEMBL5383534 | single protein format |
| CHEMBL5407530 |  |
IC50 | = | 16.7 | nM | 550.67 | N#Cc1ccc2cc1CCCCOc1ccccc1[C@@H](CO)Nc1nc(ncc1-c1cnn(C3CCNCC3)c1)N2 | Homo sapiens | CHEMBL5317022 | single protein format |
| CHEMBL4782885 |  |
IC50 | = | 18.0 | nM | 377.42 | Nc1ncc(-c2cnn(C3CCNCC3)c2)c2cc(-c3cccc(F)c3)oc12 | Homo sapiens | CHEMBL4674513 | single protein format |
| CHEMBL2086760 |  |
IC50 | = | 25.0 | nM | 447.97 | CCN1CCC(Nc2ccc3c(c2)C(=C(c2ccc(Cl)cc2)c2ncc[nH]2)C(=O)N3)CC1 | Homo sapiens | CHEMBL2091834 | single protein format |
| CHEMBL5417139 |  |
IC50 | = | 27.8 | nM | 538.66 | CN(C)CCn1cc(-c2cnc3nc2N[C@H](CO)c2ccccc2OCCCCc2cc(ccc2C#N)N3)cn1 | Homo sapiens | CHEMBL5317022 | single protein format |
| CHEMBL4790577 |  |
IC50 | = | 31.0 | nM | 435.33 | Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1NCc1c(Cl)ccc(F)c1Cl | Homo sapiens | CHEMBL4674513 | single protein format |
| CHEMBL4788727 |  |
IC50 | = | 33.0 | nM | 350.43 | Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1OCc1ccncc1 | Homo sapiens | CHEMBL4674513 | single protein format |
| CHEMBL5398202 |  |
IC50 | = | 36.0 | nM | 370.82 | N#Cc1cccc(-c2c(Cl)[nH]c3ncnc(N4CC[C@@H](F)[C@@H](N)C4)c23)c1 | Homo sapiens | CHEMBL5383534 | single protein format |
| CHEMBL518323 |  |
IC50 | = | 39.0 | nM | 436.32 | Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1OCc1c(Cl)ccc(F)c1Cl | Homo sapiens | CHEMBL4674513 | single protein format |
| CHEMBL4789200 |  |
IC50 | = | 41.0 | nM | 535.56 | CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nc(-c5ccncc5)no4)c(N[C@H](CO)c4ccccc4)n3)cc21 | Homo sapiens | CHEMBL4689492 | single protein format |
| CHEMBL4750822 |  |
IC50 | = | 43.0 | nM | 500.56 | CC(C)c1noc(-c2cnc(Nc3ccc4c(c3)C(C)(C)OC4=O)nc2N[C@H](CO)c2ccccc2)n1 | Homo sapiens | CHEMBL4689492 | single protein format |
| CHEMBL4759406 |  |
IC50 | = | 43.0 | nM | 514.59 | CC(C)(C)c1noc(-c2cnc(Nc3ccc4c(c3)C(C)(C)OC4=O)nc2N[C@H](CO)c2ccccc2)n1 | Homo sapiens | CHEMBL4689492 | single protein format |
| CHEMBL4784181 |  |
IC50 | = | 46.0 | nM | 498.54 | CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nc(C5CC5)no4)c(N[C@H](CO)c4ccccc4)n3)cc21 | Homo sapiens | CHEMBL4689492 | single protein format |
| CHEMBL601719 |  |
IC50 | = | 49.0 | nM | 450.35 | C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl | Homo sapiens | CHEMBL4674513 | single protein format |