Q8IV61 | GRP3_HUMAN | Ras guanyl-releasing protein 3 (RASGRP3)

Pfam Domain Table

AccessionDomainRangeColor
PF00130C1_1 - Phorbol esters/diacylglycerol binding domain (C1 domain)495~545
PF00617RasGEF - RasGEF domain155~330
PF13499EF-hand_7 - EF-hand domain pair427~478

3D structures mapped by conservation among orthologs


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL519741 Ki = 0.18 nM 413.51 CCCC(CCC)C(=O)OCC1(CO)C/C(=C\c2cn(C)c3ccccc23)C(=O)O1 Homo sapiens CHEMBL977319 cell-based format
CHEMBL530110 Ki = 0.2 nM 389.49 CC(C)CC(CC(C)C)C(=O)OCC1(CO)C/C(=C\c2ccccn2)C(=O)O1 Homo sapiens CHEMBL977319 cell-based format
CHEMBL3289012 Ki = 0.34 nM 413.51 CCCC(CCC)C(=O)OCC1(CO)C/C(=C\c2ccc3c(ccn3C)c2)C(=O)O1 Homo sapiens CHEMBL3294519 assay format
CHEMBL488872 Ki = 0.52 nM 411.5 CCCC(CCC)C(=O)OCC1(CO)C/C(=C\c2cnc3ccccc3c2)C(=O)O1 Homo sapiens CHEMBL977319 cell-based format
CHEMBL4160361 Ki = 0.53 nM 352.81 CC(C)(C)C(=O)OCC1(CO)C/C(=C\c2ccc(Cl)cc2)C(=O)O1 Homo sapiens CHEMBL4137136 assay format
CHEMBL488667 Ki = 0.7 nM 441.57 CC(C)CC(CC(C)C)C(=O)OCC1(CO)C/C(=C\c2cn(C)c3ccccc23)C(=O)O1 Homo sapiens CHEMBL977319 cell-based format
CHEMBL472007 Ki = 0.72 nM 361.44 CCCC(CCC)C(=O)OCC1(CO)C/C(=C\c2ccccn2)C(=O)O1 Homo sapiens CHEMBL977319 cell-based format
CHEMBL4160647 Ki = 1.01 nM 405.88 Cn1cc(/C=C2\CC(CO)(COC(=O)C(C)(C)C)OC2=O)c2cc(Cl)ccc21 Homo sapiens CHEMBL4137136 assay format
CHEMBL4162516 Ki = 1.07 nM 361.44 CN(C)c1ccc(/C=C2\CC(CO)(COC(=O)C(C)(C)C)OC2=O)cc1 Homo sapiens CHEMBL4137136 assay format
CHEMBL4163130 Ki = 1.09 nM 348.4 COc1ccc(/C=C2\CC(CO)(COC(=O)C(C)(C)C)OC2=O)cc1 Homo sapiens CHEMBL4137136 assay format
CHEMBL3289014 Ki = 1.12 nM 413.51 CCCC(CCC)C(=O)OCC1(CO)C/C(=C\c2cccc3ccn(C)c23)C(=O)O1 Homo sapiens CHEMBL3294519 assay format
CHEMBL3289013 Ki = 1.22 nM 413.51 CCCC(CCC)C(=O)OCC1(CO)C/C(=C\c2ccc3ccn(C)c3c2)C(=O)O1 Homo sapiens CHEMBL3294519 assay format
CHEMBL4174397 Ki = 1.54 nM 402.83 COc1ccc(/C=C2\CC(CO)(COC(=O)c3ccc(Cl)cc3)OC2=O)cc1 Homo sapiens CHEMBL4137136 assay format
CHEMBL472522 Ki = 1.6 nM 361.44 CCCC(CCC)C(=O)OCC1(CO)C/C(=C\c2cccnc2)C(=O)O1 Homo sapiens CHEMBL977319 cell-based format
CHEMBL3289011 Ki = 1.63 nM 413.51 CCCC(CCC)C(=O)OCC1(CO)C/C(=C\c2cccc3c2ccn3C)C(=O)O1 Homo sapiens CHEMBL3294519 assay format
CHEMBL4174723 Ki = 1.67 nM 374.46 CC(C)(C)C(=O)OCC1(CO)C/C(=C\c2csc3ccccc23)C(=O)O1 Homo sapiens CHEMBL4137136 assay format
CHEMBL529000 Ki = 1.7 nM 411.5 CCCC(CCC)C(=O)OCC1(CO)C/C(=C\c2ccc3ccccc3n2)C(=O)O1 Homo sapiens CHEMBL977319 cell-based format
CHEMBL4169454 Ki = 1.75 nM 371.43 Cn1cc(/C=C2\CC(CO)(COC(=O)C(C)(C)C)OC2=O)c2ccccc21 Homo sapiens CHEMBL4137136 assay format
CHEMBL511820 Ki = 1.8 nM 426.43 CN(C)c1ccccc1C(=O)OCC1(CO)C/C(=C\c2ccc([N+](=O)[O-])cc2)C(=O)O1 Homo sapiens CHEMBL979907 single protein format
CHEMBL4167589 Ki = 1.81 nM 415.87 CN(C)c1ccc(/C=C2\CC(CO)(COC(=O)c3ccc(Cl)cc3)OC2=O)cc1 Homo sapiens CHEMBL4137136 assay format