Q8IU80 | TMPS6_HUMAN | Transmembrane protease serine 6 (TMPRSS6)

Helixβ‑strandTurn secondary structure

Pfam Domain Table

AccessionDomainRangeColor
PF00057Ldl_recept_a491–525
PF00057Ldl_recept_a530–566
PF00089Trypsin577–806
PF01390SEA86–159

 3D structures mapped by conservation among orthologs


 [ Alpha Fold Model ] (go)



 Known binders annotated in ChEMBL

 Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL3352840 Ki = 34.8 nM 577.67 C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)c1nc2ccccc2s1 Homo sapiens CHEMBL3371671 single protein format
CHEMBL1229259 Ki = 170.0 nM 556.69 N=C(N)NCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(C(=N)N)cc1 Homo sapiens CHEMBL1810434 single protein format
CHEMBL3219087 Ki = 310.0 nM 593.75 COc1ccc(-c2cccc(S(=O)(=O)N[C@@H](Cc3cccc(C(=N)N)c3)C(=O)N3CCC(CCN)CC3)c2)c(OC)c1 Homo sapiens CHEMBL3225092 cell-based format