Q8IU80 | TMPS6_HUMAN | Transmembrane protease serine 6 (TMPRSS6)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00057 | Ldl_recept_a - Low-density lipoprotein receptor domain class A | 491~525 | |
| PF00057 | Ldl_recept_a - Low-density lipoprotein receptor domain class A | 530~566 | |
| PF00089 | Trypsin - Trypsin | 577~806 | |
| PF01390 | SEA - SEA domain | 86~159 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3352840 |  |
Ki | = | 34.8 | nM | 577.67 | C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)c1nc2ccccc2s1 | Homo sapiens | CHEMBL3371671 | single protein format |
| CHEMBL1229259 |  |
Ki | = | 170.0 | nM | 556.69 | N=C(N)NCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(C(=N)N)cc1 | Homo sapiens | CHEMBL1810434 | single protein format |
| CHEMBL3219087 |  |
Ki | = | 310.0 | nM | 593.75 | COc1ccc(-c2cccc(S(=O)(=O)N[C@@H](Cc3cccc(C(=N)N)c3)C(=O)N3CCC(CCN)CC3)c2)c(OC)c1 | Homo sapiens | CHEMBL3225092 | cell-based format |