Q86Z02 | HIPK1_HUMAN | Homeodomain-interacting protein kinase 1 (HIPK1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 190~518 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1591531 |  |
IC50 | = | 0.367 | nM | 553.67 | CS(=O)(=O)O.Cn1cc(C2=C(c3cn(CCCSC(=N)N)c4ccccc34)C(=O)NC2=O)c2ccccc21 | Homo sapiens | CHEMBL4145875 | single protein format |
| CHEMBL4750420 |  |
IC50 | = | 16.0 | nM | 311.34 | c1ccc2cc(-c3coc4ccc(-c5cn[nH]c5)nc34)ccc2c1 | Homo sapiens | CHEMBL4739022 | single protein format |
| CHEMBL4743939 |  |
IC50 | = | 33.0 | nM | 291.31 | COc1ccc(-c2coc3ccc(-c4cn[nH]c4)nc23)cc1 | Homo sapiens | CHEMBL4739022 | single protein format |
| CHEMBL3103192 |  |
IC50 | = | 40.0 | nM | 419.49 | CC(=O)Nc1cc(Nc2cc(NC3CC3)n3ncc(C#N)c3n2)ccc1N(C)CCN | Homo sapiens | CHEMBL3810700 | single protein format |
| CHEMBL4743730 |  |
IC50 | = | 51.0 | nM | 301.35 | C=C(C)c1ccc(-c2coc3ccc(-c4cn[nH]c4)nc23)cc1 | Homo sapiens | CHEMBL4739022 | single protein format |
| CHEMBL4790030 |  |
IC50 | = | 62.0 | nM | 261.28 | c1ccc(-c2coc3ccc(-c4cn[nH]c4)nc23)cc1 | Homo sapiens | CHEMBL4739022 | single protein format |
| CHEMBL1336 |  |
IC50 | = | 100.0 | nM | 464.83 | CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 | Homo sapiens | CHEMBL4739039 | single protein format |
| CHEMBL91829 |  |
IC50 | = | 100.0 | nM | 468.56 | CN(C)C[C@@H]1CCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CCO1 | Homo sapiens | CHEMBL4739039 | single protein format |
| CHEMBL4762964 |  |
IC50 | = | 125.0 | nM | 341.37 | Cn1cc(-c2ccc3occ(-c4cccc(-c5cc[nH]n5)c4)c3n2)cn1 | Homo sapiens | CHEMBL4739022 | single protein format |
| CHEMBL4789951 |  |
IC50 | = | 177.0 | nM | 341.37 | Cn1cc(-c2ccc3occ(-c4cccc(-c5cn[nH]c5)c4)c3n2)cn1 | Homo sapiens | CHEMBL4739022 | single protein format |
| CHEMBL4754195 |  |
IC50 | = | 187.0 | nM | 352.4 | Cn1cc(-c2ccc3occ(-c4cccc(-c5ccncc5)c4)c3n2)cn1 | Homo sapiens | CHEMBL4728309 | single protein format |
| CHEMBL4797457 |  |
IC50 | = | 209.0 | nM | 355.4 | Cn1cc(-c2cccc(-c3coc4ccc(-c5cnn(C)c5)nc34)c2)cn1 | Homo sapiens | CHEMBL4739022 | single protein format |
| CHEMBL4740998 |  |
IC50 | = | 220.0 | nM | 315.38 | CC1(c2ccc(-c3coc4ccc(-c5cn[nH]c5)nc34)cc2)CC1 | Homo sapiens | CHEMBL4739022 | single protein format |
| CHEMBL4790791 |  |
IC50 | = | 235.0 | nM | 265.28 | Cn1cc(-c2coc3ccc(-c4cn[nH]c4)nc23)cn1 | Homo sapiens | CHEMBL4739022 | single protein format |
| CHEMBL4777288 |  |
IC50 | = | 248.0 | nM | 317.39 | CC(C)(C)c1ccc(-c2coc3ccc(-c4cn[nH]c4)nc23)cc1 | Homo sapiens | CHEMBL4739022 | single protein format |
| CHEMBL4791451 |  |
IC50 | = | 264.0 | nM | 358.45 | Cn1cc(-c2ccc3occ(-c4cccc(C5CCNCC5)c4)c3n2)cn1 | Homo sapiens | CHEMBL4739022 | single protein format |
| CHEMBL4778370 |  |
IC50 | = | 278.0 | nM | 337.38 | c1ccc(-c2ccc(-c3coc4ccc(-c5cn[nH]c5)nc34)cc2)cc1 | Homo sapiens | CHEMBL4739022 | single protein format |
| CHEMBL4778153 |  |
IC50 | = | 285.0 | nM | 318.38 | CC(C)(C)c1ccc(-c2coc3ccc(-c4cn[nH]n4)nc23)cc1 | Homo sapiens | CHEMBL4739022 | single protein format |
| CHEMBL4741919 |  |
IC50 | = | 354.0 | nM | 372.47 | CN1CCC(c2cccc(-c3coc4ccc(-c5cnn(C)c5)nc34)c2)CC1 | Homo sapiens | CHEMBL4739022 | single protein format |
| CHEMBL4777533 |  |
IC50 | = | 545.0 | nM | 319.37 | CC(C)(C)c1ccc(-c2coc3ccc(-c4nn[nH]n4)nc23)cc1 | Homo sapiens | CHEMBL4739022 | single protein format |