Q86X55 | CARM1_HUMAN | Histone-arginine methyltransferase CARM1 (CARM1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF06325 | PrmA - Ribosomal protein L11 methyltransferase (PrmA) | 183~257 | |
| PF11531 | CARM1 - Coactivator-associated arginine methyltransferase 1 N terminal | 28~139 | |
| PF22528 | PRMT_C - Arginine methyltransferase oligomerization subdomain | 291~452 |
3D structures mapped by conservation among orthologs
[ Domain: "Arginine methyltransferase oligomerization subdomain" // PRMT5_C_1 ]
[ Domain: "S-adenosyl-L-methionine-dependent methyltransferases" // PrmA ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL584335 |  |
IC50 | = | 0.07 | nM | 408.55 | CNCCN1CCC(c2cc(C)c3[nH]c(-c4c(OC)cccc4OC)nc3c2)CC1 | Homo sapiens | CHEMBL1037272 | single protein format |
| CHEMBL571829 |  |
IC50 | = | 0.12 | nM | 396.51 | CNCCN1CCC(c2cc(C)c3[nH]c(-c4c(F)cccc4OC)nc3c2)CC1 | Homo sapiens | CHEMBL1037272 | single protein format |
| CHEMBL571639 |  |
IC50 | = | 0.26 | nM | 396.51 | CNCCN1CCC(c2cc(C)c3[nH]c(-c4ccc(F)cc4OC)nc3c2)CC1 | Homo sapiens | CHEMBL1037272 | single protein format |
| CHEMBL572103 |  |
IC50 | = | 0.41 | nM | 378.52 | CNCCN1CCC(c2cc(C)c3nc(-c4ccccc4OC)[nH]c3c2)CC1 | Homo sapiens | CHEMBL1037272 | single protein format |
| CHEMBL5272699 |  |
IC50 | = | 0.65 | nM | 463.63 | CNCCNCc1cccc(-c2nc(NC3CCOCC3)c(C)c(-c3c(C)nn(C)c3C)n2)c1 | Homo sapiens | CHEMBL5237550 | single protein format |
| CHEMBL571431 |  |
IC50 | = | 0.7 | nM | 366.47 | CNCCN1CCC(c2cnc3[nH]c(-c4cccnc4OC)nc3c2)CC1 | Homo sapiens | CHEMBL1037272 | single protein format |
| CHEMBL5270700 |  |
IC50 | = | 0.78 | nM | 513.67 | CNCCNCc1cccc(-c2nc(-c3c(C)noc3C)c(C)c(N3CCN(S(C)(=O)=O)CC3)n2)c1 | Homo sapiens | CHEMBL5237550 | single protein format |
| CHEMBL572102 |  |
IC50 | = | 0.84 | nM | 379.51 | CNCCN1CCC(c2cc(C)c3nc(-c4cccnc4OC)[nH]c3c2)CC1 | Homo sapiens | CHEMBL1037272 | single protein format |
| CHEMBL5274219 |  |
IC50 | = | 0.92 | nM | 432.57 | CNCCNCc1cccc(-c2nc(NC3CCOCC3)c(C)c(-c3cccnc3)n2)c1 | Homo sapiens | CHEMBL5237550 | single protein format |
| CHEMBL5291238 |  |
IC50 | = | 1.1 | nM | 436.56 | CNCCNCc1cccc(-c2nc(-c3c(C)noc3C)c(C)c(N3CCOCC3)n2)c1 | Homo sapiens | CHEMBL5237550 | single protein format |
| CHEMBL5271782 |  |
IC50 | = | 1.13 | nM | 469.59 | CNCCNCc1cccc(-c2nc(-c3c(C)noc3C)c(C)c(N3Cc4cccnc4C3)n2)c1 | Homo sapiens | CHEMBL5237550 | single protein format |
| CHEMBL569225 |  |
IC50 | = | 1.2 | nM | 365.48 | CNCCN1CCC(c2ccc3[nH]c(-c4cccnc4OC)nc3c2)CC1 | Homo sapiens | CHEMBL1037272 | single protein format |
| CHEMBL5288947 |  |
IC50 | = | 1.63 | nM | 450.59 | CNCCNCc1cccc(-c2nc(NC3CCOCC3)c(C)c(-c3c(C)noc3C)n2)c1 | Homo sapiens | CHEMBL5237550 | single protein format |
| CHEMBL5283756 |  |
IC50 | = | 2.3 | nM | 447.58 | CNCCNCc1cccc(-c2nc(NC3CCOCC3)c(C)c(-c3ccc(O)cc3)n2)c1 | Homo sapiens | CHEMBL5237550 | single protein format |
| CHEMBL5287824 |  |
IC50 | = | 2.46 | nM | 484.63 | CNCCNCc1cccc(-c2nc(-c3c(C)noc3C)c(C)c(N3CCS(=O)(=O)CC3)n2)c1 | Homo sapiens | CHEMBL5237550 | single protein format |
| CHEMBL571640 |  |
IC50 | = | 2.9 | nM | 379.51 | CNCCN1CCC(c2ccc3c(c2)nc(-c2cccnc2OC)n3C)CC1 | Homo sapiens | CHEMBL1037272 | single protein format |
| CHEMBL5271800 |  |
IC50 | = | 2.94 | nM | 435.58 | CNCCNCc1cccc(-c2nc(NC3CCOCC3)c(C)c(-c3ccnn3C)n2)c1 | Homo sapiens | CHEMBL5237550 | single protein format |
| CHEMBL5289496 |  |
IC50 | = | 3.68 | nM | 432.57 | CNCCNCc1cccc(-c2nc(NC3CCOCC3)c(C)c(-c3ccncc3)n2)c1 | Homo sapiens | CHEMBL5237550 | single protein format |
| CHEMBL5266562 |  |
IC50 | = | 3.7 | nM | 442.57 | CNCCNCc1cccc(-c2nc(Nc3ccccc3)c(C)c(-c3c(C)noc3C)n2)c1 | Homo sapiens | CHEMBL5237550 | single protein format |
| CHEMBL5289683 |  |
IC50 | = | 3.78 | nM | 449.6 | CNCCNCc1cccc(-c2nc(NC3CCOCC3)c(C)c(-c3cn(C)nc3C)n2)c1 | Homo sapiens | CHEMBL5237550 | single protein format |