Q86WV6 | STING_HUMAN | Stimulator of interferon genes protein (STING1)

Pfam Domain Table

AccessionDomainRangeColor
PF15009STING_LBD - STING ligand-binding domain154~337
PF23417STING_TM - STING transmembrane domain45~152

3D structures mapped by conservation among orthologs

[ Domain: "STING C-terminal domain" // TMEM173 ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL5402080 IC50 = 11.5 nM 299.76 Cc1ccc(NC(=O)Nc2c[nH]c3ccccc23)cc1Cl Homo sapiens CHEMBL5391781 cell-based format
CHEMBL5439497 IC50 = 26.5 nM 319.29 O=C(Nc1ccc(C(F)(F)F)cc1)Nc1c[nH]c2ccccc12 Homo sapiens CHEMBL5391781 cell-based format
CHEMBL5426770 IC50 = 29.0 nM 330.19 O=C(Nc1cccc(Br)c1)Nc1c[nH]c2ccccc12 Homo sapiens CHEMBL5391781 cell-based format
CHEMBL5413596 IC50 = 35.5 nM 335.29 O=C(Nc1ccc(OC(F)(F)F)cc1)Nc1c[nH]c2ccccc12 Homo sapiens CHEMBL5391781 cell-based format
CHEMBL4554395 IC50 = 41.0 nM 508.04 CC(C)(C)c1ccc(N2C(=O)c3ccccc3[C@H](C(=O)O)[C@H]2c2ccc3c(c2)SCCO3)cc1Cl Homo sapiens CHEMBL4385500 cell membrane format
CHEMBL5439452 IC50 = 64.5 nM 283.31 Cc1ccc(NC(=O)Nc2c[nH]c3ccccc23)cc1F Homo sapiens CHEMBL5391781 cell-based format
CHEMBL4557373 IC50 = 68.0 nM 523.99 CC(C)(C)c1ccc(N2C(=O)c3cc(F)ccc3[C@H](CC(=O)O)[C@H]2c2ccc3c(c2)OCCO3)cc1Cl Homo sapiens CHEMBL4385500 cell membrane format
CHEMBL5428553 IC50 = 70.0 nM 285.73 O=C(Nc1ccc(Cl)cc1)Nc1c[nH]c2ccccc12 Homo sapiens CHEMBL5391781 cell-based format
CHEMBL5189857 IC50 = 76.0 nM 462.5 O=C(Nc1ccc(O)c(NS(=O)(=O)c2ccc(F)cc2)c1)c1ccc(-c2ccccc2)cc1 Homo sapiens CHEMBL5166003 single protein format
CHEMBL4468037 IC50 = 84.0 nM 491.97 CC(C)(C)c1ccc(N2C(=O)c3ccccc3[C@H](C(=O)O)[C@H]2c2ccc3c(c2)OCCO3)cc1Cl Homo sapiens CHEMBL4385500 cell membrane format
CHEMBL5397748 IC50 = 88.0 nM 293.37 CC(C)c1ccc(NC(=O)Nc2c[nH]c3ccccc23)cc1 Homo sapiens CHEMBL5391781 cell-based format
CHEMBL4524926 IC50 = 106.0 nM 505.01 CN1CCOc2ccc([C@@H]3[C@@H](C(=O)O)c4ccccc4C(=O)N3c3ccc(C(C)(C)C)c(Cl)c3)cc21 Homo sapiens CHEMBL4385500 cell membrane format
CHEMBL5179819 IC50 = 156.0 nM 279.34 CCc1ccc(NC(=O)Nc2c[nH]c3ccccc23)cc1 Homo sapiens CHEMBL5391781 cell-based format
CHEMBL5175901 IC50 = 379.4 nM 591.67 CCn1nc(C)cc1C(=O)Nc1nc2cc(C(N)=O)cc(OCCCOC)c2n1CCCNC(=O)OCc1ccccc1 Homo sapiens CHEMBL5116531 single protein format
CHEMBL4450597 IC50 = 384.0 nM 524.11 CC(C)(C)c1ccc(N2C(=O)c3ccccc3[C@H](C(=O)O)[C@H]2c2ccc3c(c2)SCCS3)cc1Cl Homo sapiens CHEMBL4385500 cell membrane format
CHEMBL5419883 IC50 = 406.5 nM 279.34 Cc1ccc(NC(=O)Nc2c[nH]c3ccccc23)cc1C Homo sapiens CHEMBL5391781 cell-based format
CHEMBL5401389 IC50 = 429.0 nM 269.28 O=C(Nc1ccc(F)cc1)Nc1c[nH]c2ccccc12 Homo sapiens CHEMBL5391781 cell-based format
CHEMBL5080916 IC50 = 470.0 nM 411.76 O=C(NCc1cc2cc(Cl)c3oc(=O)[nH]c(=O)c3c2o1)c1cnn2cccnc12 Homo sapiens CHEMBL5045537 single protein format
CHEMBL5432303 IC50 = 525.5 nM 330.19 O=C(Nc1ccc(Br)cc1)Nc1c[nH]c2ccccc12 Homo sapiens CHEMBL5391781 cell-based format
CHEMBL5081567 IC50 = 580.0 nM 386.75 O=C(O)c1c(O)c(Cl)cc2cc(CNC(=O)c3cnn4cccnc34)oc12 Homo sapiens CHEMBL5045537 single protein format