Q86V86 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 40~293 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4741714 |  |
IC50 | = | 0.009 | nM | 439.48 | C[C@@H]1C[C@H](N)C[C@H](c2ccccc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C1 | Homo sapiens | CHEMBL4687901 | single protein format |
| CHEMBL3942186 |  |
IC50 | = | 0.027 | nM | 435.48 | C[C@@H]1C[C@H](N)CN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C1 | Homo sapiens | CHEMBL3864869 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 0.1206 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4050769 | single protein format |
| CHEMBL3687474 |  |
IC50 | = | 0.22 | nM | 512.59 | C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H](N)[C@H]1OCCC#N | Homo sapiens | CHEMBL3707725 | single protein format |
| CHEMBL3691919 |  |
IC50 | = | 0.26 | nM | 565.67 | C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H](N)[C@H]1OCCS(C)(=O)=O | Homo sapiens | CHEMBL3707725 | single protein format |
| CHEMBL4108864 |  |
IC50 | = | 0.307 | nM | 391.5 | Nc1nnc(-c2ccc3[nH]cc(-c4cccc(N5CCCC[C@@H]5N)n4)c3c2)s1 | Homo sapiens | CHEMBL3888379 | single protein format |
| CHEMBL3687492 |  |
IC50 | = | 0.32 | nM | 473.55 | CO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H]1C | Homo sapiens | CHEMBL3707725 | single protein format |
| CHEMBL3905618 |  |
IC50 | = | 0.346 | nM | 373.42 | c1cc2[nH]cc(-c3cncc(C4CC4)n3)c2cc1-c1nnc(NC2CNC2)o1 | Homo sapiens | CHEMBL3888379 | single protein format |
| CHEMBL3691950 |  |
IC50 | = | 0.36 | nM | 524.55 | C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H](N)[C@H]1OCCC#N | Homo sapiens | CHEMBL3707725 | single protein format |
| CHEMBL3691930 |  |
IC50 | = | 0.39 | nM | 577.63 | C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H](N)[C@H]1OCCS(C)(=O)=O | Homo sapiens | CHEMBL3707725 | single protein format |
| CHEMBL3393706 |  |
IC50 | = | 0.4 | nM | 433.46 | Fc1cccc(F)c1-c1ccc2[nH]nc(-c3cncc(O[C@H]4CNCCC45CC5)n3)c2c1 | Homo sapiens | CHEMBL3396421 | single protein format |
| CHEMBL3687479 |  |
IC50 | = | 0.4 | nM | 473.55 | CO[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H]1C | Homo sapiens | CHEMBL3707725 | single protein format |
| CHEMBL4062256 |  |
IC50 | = | 0.4 | nM | 424.89 | COc1ccc2c(c1CN1CCNCC1)O/C(=C\c1c[nH]c3nc(Cl)ccc13)C2=O | Homo sapiens | CHEMBL3997631 | cell-based format |
| CHEMBL3691958 |  |
IC50 | = | 0.41 | nM | 529.52 | COC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H]1C | Homo sapiens | CHEMBL3707725 | single protein format |
| CHEMBL3901582 |  |
IC50 | = | 0.425 | nM | 373.45 | Cc1cn(-c2cccc(-c3c[nH]c4ccc(-c5nnc(N)s5)cc34)n2)cn1 | Homo sapiens | CHEMBL3888379 | single protein format |
| CHEMBL3687482 |  |
IC50 | = | 0.43 | nM | 517.56 | COC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H]1C | Homo sapiens | CHEMBL3707725 | single protein format |
| CHEMBL3919337 |  |
IC50 | = | 0.435 | nM | 360.42 | CC(C)Nc1nnc(-c2ccc3[nH]cc(-c4nccc(C5CC5)n4)c3c2)o1 | Homo sapiens | CHEMBL3888379 | single protein format |
| CHEMBL3687468 |  |
IC50 | = | 0.49 | nM | 542.56 | COC(=O)N(C)[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C)cc3F)n2)C[C@@H]1C | Homo sapiens | CHEMBL3707725 | single protein format |
| CHEMBL3687471 |  |
IC50 | = | 0.49 | nM | 528.54 | COC(=O)N(C)[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C | Homo sapiens | CHEMBL3707725 | single protein format |
| CHEMBL3932201 |  |
IC50 | = | 0.498 | nM | 360.42 | CC(C)Nc1nnc(-c2ccc3[nH]cc(-c4cncc(C5CC5)n4)c3c2)o1 | Homo sapiens | CHEMBL3888379 | single protein format |