Q86UE8 | TLK2_HUMAN | Serine/threonine-protein kinase tousled-like 2 (TLK2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 464~741 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL388978 |  |
IC50 | = | 3.66 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328634 | single protein format |
| CHEMBL5204542 |  |
IC50 | = | 18.65 | nM | 388.47 | CN1CCCC1CCO/N=C1C(=C2/C(=O)Nc3ccccc32)/Nc2ccccc2/1 | Homo sapiens | CHEMBL5144097 | cell-based format |
| CHEMBL5188455 |  |
IC50 | = | 33.15 | nM | 374.44 | CN1CCC(O/N=C2C(=C3/C(=O)Nc4ccccc43)/Nc3ccccc3/2)CC1 | Homo sapiens | CHEMBL5144097 | cell-based format |
| CHEMBL5173181 |  |
IC50 | = | 163.4 | nM | 401.51 | CN1CCCCC1CCO/N=C1C(=C2/C(=O)Nc3ccccc32)/Cc2ccccc2/1 | Homo sapiens | CHEMBL5144097 | cell-based format |