Q86U44 | MTA70_HUMAN | N6-adenosine-methyltransferase catalytic subunit (METTL3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF05063 | MT-A70 - MT-A70 | 389~550 |
3D structures mapped by conservation among orthologs
[ Domain: "S-adenosyl-L-methionine-dependent methyltransferases" // MT-A70 ]
[ Domain: "CCCH zinc finger" // UNK_F_TYPE ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5396973 |  |
IC50 | = | 3.63 | nM | 442.53 | COc1cc(-c2cn(Cc3cn4cc(CNCC5CCC5)ccc4n3)nn2)c2cn[nH]c2c1 | Homo sapiens | CHEMBL5393575 | assay format |
| CHEMBL5438009 |  |
IC50 | = | 4.23 | nM | 428.5 | Oc1cc(-c2cn(Cc3cn4cc(CNCC5CCC5)ccc4n3)nn2)c2cn[nH]c2c1 | Homo sapiens | CHEMBL5393575 | assay format |
| CHEMBL5405105 |  |
IC50 | = | 4.35 | nM | 446.95 | Clc1cc(-c2cn(Cc3cn4cc(CNCC5CCC5)ccc4n3)nn2)c2cn[nH]c2c1 | Homo sapiens | CHEMBL5393575 | assay format |
| CHEMBL5425488 |  |
IC50 | = | 4.44 | nM | 491.4 | Brc1cc(-c2cn(Cc3cn4cc(CNCC5CCC5)ccc4n3)nn2)c2cn[nH]c2c1 | Homo sapiens | CHEMBL5393575 | assay format |
| CHEMBL5077332 |  |
IC50 | = | 5.0 | nM | 513.64 | CNc1cc(N2CCC3(CC2)CN(c2cc(F)c(CN4CCC(C)(C)CC4)cc2F)CC(=O)N3)ncn1 | Homo sapiens | CHEMBL5053965 | cell-based format |
| CHEMBL5412324 |  |
IC50 | = | 5.67 | nM | 430.49 | Fc1cc(-c2cn(Cc3cn4cc(CNCC5CCC5)ccc4n3)nn2)c2cn[nH]c2c1 | Homo sapiens | CHEMBL5393575 | assay format |
| CHEMBL5423596 |  |
IC50 | = | 5.76 | nM | 440.56 | CC1(C)CCN(Cc2ccc3nc(Cn4cc(-c5cccc6[nH]ncc56)nn4)cn3c2)CC1 | Homo sapiens | CHEMBL5393575 | assay format |
| CHEMBL5433927 |  |
IC50 | = | 5.776 | nM | 412.5 | c1cc(-c2cn(Cc3cn4cc(CNCC5CCC5)ccc4n3)nn2)c2cn[nH]c2c1 | Homo sapiens | CHEMBL5393575 | assay format |
| CHEMBL5433144 |  |
IC50 | = | 5.8 | nM | 535.45 | OC1(CNCc2ccc3nc(Cn4cc(-c5cc(Br)cc6[nH]ncc56)nn4)cn3c2)CCCCC1 | Homo sapiens | CHEMBL5393575 | assay format |
| CHEMBL5407802 |  |
IC50 | = | 5.92 | nM | 462.95 | OC1(CNCc2ccc3nc(Cn4cc(-c5cc(Cl)cc6[nH]ncc56)nn4)cn3c2)CCC1 | Homo sapiens | CHEMBL5393575 | assay format |
| CHEMBL5411328 |  |
IC50 | < | 6.0 | nM | 555.45 | Nc1ncnc2c1c(Br)cn2[C@@H]1C[C@H](c2ccc3cc(CNCC45CC(F)(C4)C5)[nH]c3c2)[C@@H](O)[C@H]1O | Homo sapiens | CHEMBL5393616 | assay format |
| CHEMBL5407409 |  |
IC50 | < | 6.0 | nM | 496.38 | Nc1ncnc2c1c(Br)cn2[C@@H]1O[C@H](/C=C/CCCNCC23CC(F)(C2)C3)[C@@H](O)[C@H]1O | Homo sapiens | CHEMBL5393616 | assay format |
| CHEMBL5404800 |  |
IC50 | = | 6.009 | nM | 430.49 | Fc1ccc(-c2cn(Cc3cn4cc(CNCC5CCC5)ccc4n3)nn2)c2cn[nH]c12 | Homo sapiens | CHEMBL5393575 | assay format |
| CHEMBL5415737 |  |
IC50 | = | 6.1 | nM | 551.49 | Nc1ncnc2c1c(Br)cn2[C@@H]1C[C@H](c2ccc3cc(CN4CCC5(CCC5)C4)[nH]c3c2)[C@@H](O)[C@H]1O | Homo sapiens | CHEMBL5393616 | assay format |
| CHEMBL5413095 |  |
IC50 | = | 6.1 | nM | 507.4 | OC1(CNCc2ccc3nc(Cn4cc(-c5cc(Br)cc6[nH]ncc56)nn4)cn3c2)CCC1 | Homo sapiens | CHEMBL5393575 | assay format |
| CHEMBL5410561 |  |
IC50 | = | 6.1 | nM | 446.49 | O=C(NCc1cn2cc(CNCC34CC(F)(C3)C4)ccc2n1)c1cc(=O)n2ccccc2n1 | Homo sapiens | CHEMBL5393575 | assay format |
| CHEMBL5417468 |  |
IC50 | = | 6.1 | nM | 442.53 | COc1ccc2[nH]ncc2c1-c1cn(Cc2cn3cc(CNCC4CCC4)ccc3n2)nn1 | Homo sapiens | CHEMBL5393575 | assay format |
| CHEMBL5398269 |  |
IC50 | = | 6.1 | nM | 511.0 | Nc1ncnc2c1c(Cl)cn2[C@@H]1C[C@H](c2ccc3cc(CNCC45CC(F)(C4)C5)[nH]c3c2)[C@@H](O)[C@H]1O | Homo sapiens | CHEMBL5393616 | assay format |
| CHEMBL5414110 |  |
IC50 | = | 6.1 | nM | 494.55 | Nc1ncnc2c1c(F)cn2[C@@H]1C[C@H](c2ccc3cc(CNCC45CC(F)(C4)C5)[nH]c3c2)[C@@H](O)[C@H]1O | Homo sapiens | CHEMBL5393616 | assay format |
| CHEMBL5424750 |  |
IC50 | = | 6.1 | nM | 448.96 | CC(C)(C)CNCc1ccc2nc(Cn3cc(-c4cc(Cl)cc5[nH]ncc45)nn3)cn2c1 | Homo sapiens | CHEMBL5393575 | assay format |