Q86TI2 | DPP9_HUMAN | Dipeptidyl peptidase 9 (DPP9)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00326 | Peptidase_S9 - Prolyl oligopeptidase family | 663~863 | |
| PF00930 | DPPIV_N - Dipeptidyl peptidase IV (DPP IV) N-terminal region | 146~570 | |
| PF19520 | Dpp_8_9_N - Dipeptidyl peptidase 8 and 9 N-terminal | 22~135 |
3D structures mapped by conservation among orthologs
[ Domain: "8-bladed" // F_UNCLASSIFIED ]
[ Domain: "8-bladed" // UNK_F_TYPE ]
[ Domain: "8-bladed" // UNK_F_TYPE ]
[ Domain: "alpha/beta-Hydrolases" // Hydrolase_4 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2063040 |  |
IC50 | = | 0.31 | nM | 287.13 | N=C(N)NCCC[C@H](N)C(=O)N1C[C@@H](O)C[C@H]1B(O)O | Homo sapiens | CHEMBL2066845 | cell-based format |
| CHEMBL5425473 |  |
IC50 | = | 1.0 | nM | 274.36 | N[C@H](C(=O)N1Cc2ccccc2C1)C1CCC(O)CC1 | Homo sapiens | CHEMBL5368775 | single protein format |
| CHEMBL195189 |  |
IC50 | = | 2.0 | nM | 214.07 | CC(C)[C@H](N)C(=O)N1CCC[C@@H]1B(O)O | Homo sapiens | CHEMBL880437 | single protein format |
| CHEMBL67279 |  |
IC50 | = | 2.0 | nM | 214.07 | CC(C)[C@H](N)C(=O)N1CCC[C@H]1B(O)O | Homo sapiens | CHEMBL902273 | single protein format |
| CHEMBL2063033 |  |
IC50 | = | 2.1 | nM | 228.06 | O=C([C@@H]1CCCN1)N1C[C@@H](O)C[C@H]1B(O)O | Homo sapiens | CHEMBL2066845 | cell-based format |
| CHEMBL63860 |  |
IC50 | = | 2.8 | nM | 186.02 | C[C@H](N)C(=O)N1CCC[C@H]1B(O)O | Homo sapiens | CHEMBL2066845 | cell-based format |
| CHEMBL5402430 |  |
IC50 | = | 3.0 | nM | 461.55 | CC(C)(C)OC(=O)NC12CC3CC(CC(NCC(=O)N4Cc5cc(F)c(F)cc5C4)(C3)C1)C2 | Homo sapiens | CHEMBL5368767 | cell-based format |
| CHEMBL2063024 |  |
IC50 | = | 3.5 | nM | 202.02 | C[C@H](N)C(=O)N1C[C@@H](O)C[C@H]1B(O)O | Homo sapiens | CHEMBL2066845 | cell-based format |
| CHEMBL5398643 |  |
IC50 | = | 4.0 | nM | 442.58 | CC(C)(C)NC(=O)NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2 | Homo sapiens | CHEMBL5368767 | cell-based format |
| CHEMBL472128 |  |
IC50 | = | 4.6 | nM | 391.48 | N#C[C@@H]1C[C@H](N=[N+]=[N-])CN1C(=O)[C@@H](N)CCCCNc1ccc2ccccc2c1 | Homo sapiens | CHEMBL938685 | single protein format |
| CHEMBL194852 |  |
IC50 | = | 4.6 | nM | 228.1 | CCCC[C@H](N)C(=O)N1CCC[C@@H]1B(O)O | Homo sapiens | CHEMBL880437 | single protein format |
| CHEMBL471547 |  |
IC50 | = | 6.3 | nM | 250.31 | CC[C@@H](C)[C@H](N)C(=O)N1C[C@@H](N=[N+]=[N-])C[C@H]1C#N | Homo sapiens | CHEMBL938685 | single protein format |
| CHEMBL2063031 |  |
IC50 | = | 6.4 | nM | 244.1 | CC(C)(C)[C@H](N)C(=O)N1C[C@@H](O)C[C@H]1B(O)O | Homo sapiens | CHEMBL2066845 | cell-based format |
| CHEMBL194428 |  |
IC50 | = | 6.7 | nM | 215.06 | NCC[C@H](N)C(=O)N1CCC[C@@H]1B(O)O | Homo sapiens | CHEMBL880437 | single protein format |
| CHEMBL2063035 |  |
IC50 | = | 9.3 | nM | 244.06 | O=C([C@@H]1C[C@@H](O)CN1)N1C[C@@H](O)C[C@H]1B(O)O | Homo sapiens | CHEMBL2066845 | cell-based format |
| CHEMBL2063037 |  |
IC50 | = | 9.5 | nM | 244.06 | O=C([C@@H]1C[C@H](O)CN1)N1C[C@@H](O)C[C@H]1B(O)O | Homo sapiens | CHEMBL2066845 | cell-based format |
| CHEMBL2063026 |  |
IC50 | = | 11.0 | nM | 204.01 | C[C@H](N)C(=O)N1C[C@H](F)C[C@H]1B(O)O | Homo sapiens | CHEMBL2066845 | cell-based format |
| CHEMBL5421476 |  |
IC50 | = | 14.0 | nM | 443.56 | CC(C)(C)OC(=O)NC12CC3CC(CC(NCC(=O)N4Cc5ccc(F)cc5C4)(C3)C1)C2 | Homo sapiens | CHEMBL5368767 | cell-based format |
| CHEMBL5406353 |  |
IC50 | = | 14.0 | nM | 535.69 | O=C(NC(c1ccccc1)c1ccccc1)OC12CC3CC(CC(NCC(=O)N4Cc5ccccc5C4)(C3)C1)C2 | Homo sapiens | CHEMBL5368767 | cell-based format |
| CHEMBL2063032 |  |
IC50 | = | 14.0 | nM | 244.1 | CC(C)(C)[C@H](N)C(=O)N1C[C@H](O)C[C@H]1B(O)O | Homo sapiens | CHEMBL2066845 | cell-based format |