Q7Z601 | GP142_HUMAN | Probable G-protein coupled receptor 142 (GPR142)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 180~410 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4750179 |  |
IC50 | = | 37.0 | nM | 403.87 | Cc1cc(-c2ccc3c(c2)-c2nnc(Nc4cccc(Cl)c4)n2CCO3)ccn1 | Homo sapiens | CHEMBL4717447 | cell-based format |
| CHEMBL4798957 |  |
IC50 | = | 45.0 | nM | 453.42 | Cc1cc(-c2ccc3c(c2)-c2nnc(Nc4cccc(OC(F)(F)F)c4)n2CCO3)ccn1 | Homo sapiens | CHEMBL4717447 | cell-based format |
| CHEMBL4790150 |  |
IC50 | = | 48.0 | nM | 423.4 | FC(F)(F)c1cccc(Nc2nnc3n2CCOc2ccc(-c4ccncc4)cc2-3)c1 | Homo sapiens | CHEMBL4717447 | cell-based format |
| CHEMBL4746135 |  |
IC50 | = | 56.0 | nM | 422.85 | Cc1cc(-c2ccc3c(c2)-c2nnc(Oc4cccc(Cl)c4F)n2CCO3)ccn1 | Homo sapiens | CHEMBL4717447 | cell-based format |
| CHEMBL4761139 |  |
IC50 | = | 58.0 | nM | 404.86 | Cc1cc(-c2ccc3c(c2)-c2nnc(Oc4cccc(Cl)c4)n2CCO3)ccn1 | Homo sapiens | CHEMBL4717447 | cell-based format |
| CHEMBL4755454 |  |
IC50 | = | 63.0 | nM | 439.4 | FC(F)(F)Oc1cccc(Nc2nnc3n2CCOc2ccc(-c4ccncc4)cc2-3)c1 | Homo sapiens | CHEMBL4717447 | cell-based format |
| CHEMBL4788072 |  |
IC50 | = | 63.0 | nM | 437.43 | Cc1cc(-c2ccc3c(c2)-c2nnc(Nc4cccc(C(F)(F)F)c4)n2CCO3)ccn1 | Homo sapiens | CHEMBL4717447 | cell-based format |
| CHEMBL4752684 |  |
IC50 | = | 74.0 | nM | 451.45 | CCc1cc(-c2ccc3c(c2)-c2nnc(Nc4cccc(C(F)(F)F)c4)n2CCO3)ccn1 | Homo sapiens | CHEMBL4717447 | cell-based format |
| CHEMBL4751613 |  |
IC50 | = | 78.0 | nM | 454.41 | Cc1cc(-c2ccc3c(c2)-c2nnc(Oc4cccc(OC(F)(F)F)c4)n2CCO3)ccn1 | Homo sapiens | CHEMBL4717447 | cell-based format |
| CHEMBL4763234 |  |
IC50 | = | 80.0 | nM | 370.41 | N#Cc1cccc(NC(=O)N2CCOc3ccc(-c4ccncc4)cc3C2)c1 | Homo sapiens | CHEMBL4717447 | cell-based format |
| CHEMBL4743615 |  |
IC50 | = | 89.0 | nM | 454.41 | Cc1cc(-c2ccc3c(c2)-c2nnc(Oc4ccccc4OC(F)(F)F)n2CCO3)ccn1 | Homo sapiens | CHEMBL4717447 | cell-based format |
| CHEMBL4759692 |  |
IC50 | = | 102.0 | nM | 404.86 | Cc1cc(-c2ccc3c(c2)-c2nnc(Oc4ccccc4Cl)n2CCO3)ccn1 | Homo sapiens | CHEMBL4717447 | cell-based format |
| CHEMBL4787638 |  |
IC50 | = | 108.0 | nM | 379.85 | O=C(Nc1cccc(Cl)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | Homo sapiens | CHEMBL4717447 | cell-based format |
| CHEMBL4783052 |  |
IC50 | = | 110.0 | nM | 359.39 | N#Cc1cccc(NC(=O)N2CCOc3ccc(-n4ccnc4)cc3C2)c1 | Homo sapiens | CHEMBL4717447 | cell-based format |
| CHEMBL4753373 |  |
IC50 | = | 132.0 | nM | 397.84 | O=C(Nc1ccc(F)c(Cl)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | Homo sapiens | CHEMBL4717447 | cell-based format |
| CHEMBL4755668 |  |
IC50 | = | 140.0 | nM | 414.29 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | Homo sapiens | CHEMBL4717447 | cell-based format |
| CHEMBL4782723 |  |
IC50 | = | 146.0 | nM | 413.31 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCNc2ccc(-c3ccncc3)cc2C1 | Homo sapiens | CHEMBL4717447 | cell-based format |
| CHEMBL4756319 |  |
IC50 | = | 158.0 | nM | 413.4 | O=C(Nc1cccc(C(F)(F)F)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | Homo sapiens | CHEMBL4717447 | cell-based format |
| CHEMBL4800653 |  |
IC50 | = | 163.0 | nM | 397.84 | O=C(Nc1cccc(Cl)c1F)N1CCOc2ccc(-c3ccncc3)cc2C1 | Homo sapiens | CHEMBL4717447 | cell-based format |
| CHEMBL4750165 |  |
IC50 | = | 187.0 | nM | 405.45 | COc1cccc(NC(=O)N2CCOc3ccc(-c4ccncc4OC)cc3C2)c1 | Homo sapiens | CHEMBL4717447 | cell-based format |