Q7Z3E1 | PARPT_HUMAN | Protein mono-ADP-ribosyltransferase TIPARP (TIPARP)

Helixβ‑strandTurn secondary structure

Pfam Domain Table

AccessionDomainRangeColor
PF00644PARP474–649

 3D structures mapped by conservation among orthologs


 [ Alpha Fold Model ] (go)



 Known binders annotated in ChEMBL

 IC50 CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL5400567 IC50 = 0.11 nM 559.48 C[C@@H](CCCn1ccc2cc(-c3ncc4c(n3)NC(=O)CO4)c(F)cc2c1=O)Nc1cn[nH]c(=O)c1C(F)(F)F Homo sapiens CHEMBL5393109 single protein format
CHEMBL5394931 IC50 = 0.141 nM 495.38 O=C([C@@H](O)CCNc1cc(C(F)(F)F)c(=O)[nH]n1)N1CCN(c2ncc(C(F)(F)F)cn2)CC1 Homo sapiens CHEMBL5369275 single protein format
CHEMBL5413717 IC50 = 0.151 nM 555.48 O=C(CCCN(c1ccccc1)c1cc(C(F)(F)F)c(=O)[nH]n1)N1CCN(c2ncc(C(F)(F)F)cn2)CC1 Homo sapiens CHEMBL5369275 single protein format
CHEMBL5415829 IC50 = 0.179 nM 507.44 CCN(CCCC(=O)N1CCN(c2ncc(C(F)(F)F)cn2)CC1)c1cc(C(F)(F)F)c(=O)[nH]n1 Homo sapiens CHEMBL5369275 single protein format
CHEMBL5407242 IC50 = 0.188 nM 537.91 C[C@@H](CCCn1ccc2cc(-c3ncc(Cl)c(N)n3)c(F)cc2c1=O)Nc1cn[nH]c(=O)c1C(F)(F)F Homo sapiens CHEMBL5393109 single protein format
CHEMBL5403305 IC50 = 0.21 nM 488.5 CCC(CC)N1CCN(C(=O)c2cc(Cn3c(=O)[n-]c(=O)c4ccccc43)ccc2F)CC1=O.[Na+] Homo sapiens CHEMBL5373895 cell-based format
CHEMBL5419793 IC50 = 0.212 nM 519.45 O=C(CC[C@@H]1CCCN1c1cc(C(F)(F)F)c(=O)[nH]n1)N1CCN(c2ncc(C(F)(F)F)cn2)CC1 Homo sapiens CHEMBL5369275 single protein format
CHEMBL5422627 IC50 = 0.232 nM 567.49 O=C(CCC1Cc2ccccc2N1c1cc(C(F)(F)F)c(=O)[nH]n1)N1CCN(c2ncc(C(F)(F)F)cn2)CC1 Homo sapiens CHEMBL5369275 single protein format
CHEMBL5409582 IC50 = 0.233 nM 493.41 CN(CCCC(=O)N1CCN(c2ncc(C(F)(F)F)cn2)CC1)c1cc(C(F)(F)F)c(=O)[nH]n1 Homo sapiens CHEMBL5369275 single protein format
CHEMBL5425262 IC50 = 0.263 nM 479.39 O=C(CCCNc1cc(C(F)(F)F)c(=O)[nH]n1)N1CCN(c2ncc(C(F)(F)F)cn2)CC1 Homo sapiens CHEMBL5369275 single protein format
CHEMBL5409458 IC50 = 0.288 nM 478.4 O=C(CCCCc1cc(C(F)(F)F)c(=O)[nH]n1)N1CCN(c2ncc(C(F)(F)F)cn2)CC1 Homo sapiens CHEMBL5369275 single protein format
CHEMBL5417113 IC50 = 0.405 nM 512.41 O=C(c1cccc(Cc2cc(C(F)(F)F)c(=O)[nH]n2)c1)N1CCN(c2ncc(C(F)(F)F)cn2)CC1 Homo sapiens CHEMBL5369275 single protein format
CHEMBL5209116 IC50 = 0.584 nM 563.46 C[C@@H](COCCC(=O)N1CCN2c3ncc(C(F)(F)F)cc3NC(=O)C2C1)Nc1cn[nH]c(=O)c1C(F)(F)F Homo sapiens CHEMBL5131328 single protein format
CHEMBL5177385 IC50 = 0.6114 nM 589.5 CN1C(=O)[C@@H]2CN(C(=O)CCOC[C@@H]3CCN3c3cn[nH]c(=O)c3C(F)(F)F)CCN2c2ncc(C(F)(F)F)cc21 Homo sapiens CHEMBL5131328 single protein format
CHEMBL5181016 IC50 = 0.648 nM 589.5 C=CN1C(=O)[C@@H]2CN(C(=O)CCOC[C@H](C)Nc3cn[nH]c(=O)c3C(F)(F)F)CCN2c2ncc(C(F)(F)F)cc21 Homo sapiens CHEMBL5131328 single protein format
CHEMBL5407196 IC50 = 0.671 nM 533.48 O=C(CC[C@@H]1CCCCN1c1cc(C(F)(F)F)c(=O)[nH]n1)N1CCN(c2ncc(C(F)(F)F)cn2)CC1 Homo sapiens CHEMBL5369275 single protein format
CHEMBL5190796 IC50 = 0.802 nM 536.43 CC(COCCC(=O)N1CCN2c3ncc(C(F)(F)F)cc3NC2C1)Oc1cn[nH]c(=O)c1C(F)(F)F Homo sapiens CHEMBL5131328 single protein format
CHEMBL5183629 IC50 = 0.806 nM 581.49 [2H]C([2H])([2H])N1C(=O)C2CN(C(=O)CCOC[C@H](C)Oc3cn[nH]c(=O)c3C(F)(F)F)CCN2c2ncc(C(F)(F)F)cc21 Homo sapiens CHEMBL5131328 single protein format
CHEMBL5202833 IC50 = 0.87 nM 589.5 CN1C(=O)[C@H]2CN(C(=O)CCOC[C@@H]3CCN3c3cn[nH]c(=O)c3C(F)(F)F)CCN2c2ncc(C(F)(F)F)cc21 Homo sapiens CHEMBL5131328 single protein format
CHEMBL5174619 IC50 = 0.966 nM 577.49 C[C@@H](COCCC(=O)N1CCN2c3ncc(C(F)(F)F)cc3N(C)C(=O)C2C1)Nc1cn[nH]c(=O)c1C(F)(F)F Homo sapiens CHEMBL5131328 single protein format