Q7KZI7 | MARK2_HUMAN | Serine/threonine-protein kinase MARK2 (MARK2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 53~304 | |
| PF00627 | UBA - UBA/TS-N domain | 325~360 | |
| PF02149 | KA1 - Kinase associated domain 1 | 746~788 |
3D structures mapped by conservation among orthologs
[ Domain: "RuvA-C, UBA, CRAL/TRIO-N, HBS1" // UBA_MELK ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL388978 |  |
IC50 | = | 0.133 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328484 | single protein format |
| CHEMBL5305160 |  |
IC50 | = | 2.0 | nM | 469.59 | CC1(C)C(=O)N([C@H]2CCc3c(O)cccc32)c2nc(Nc3cccc(CN4CCCC4)c3)ncc21 | Homo sapiens | CHEMBL5345921 | single protein format |
| CHEMBL4116008 |  |
IC50 | = | 4.0 | nM | 445.55 | CCS(=O)(=O)N1CCN(c2ccc(Nc3ncc(C(N)=O)c(NC4CC4)n3)cc2)CC1 | Homo sapiens | CHEMBL5347024 | single protein format |
| CHEMBL3605057 |  |
IC50 | = | 52.0 | nM | 464.61 | O=C(NCCCNc1nc(Nc2cccc(CN3CCOCC3)c2)ncc1C1CC1)C1CCC1 | Homo sapiens | CHEMBL5345921 | single protein format |