Q6ZQW0 | I23O2_HUMAN | Indoleamine 2,3-dioxygenase 2 (IDO2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01231 | IDO - Indoleamine 2,3-dioxygenase | 16~400 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5219888 |  |
IC50 | = | 112.0 | nM | 541.37 | O=C(NCc1cn(CCNc2nonc2/C(=N/O)NCc2cccc(Br)c2)nn1)c1ccccn1 | Homo sapiens | CHEMBL5216514 | single protein format |
| CHEMBL5220224 |  |
IC50 | = | 134.0 | nM | 533.32 | O=C(NCc1cn(CCNc2nonc2/C(=N/O)Nc2ccc(F)c(Br)c2)nn1)c1ccc[nH]1 | Homo sapiens | CHEMBL5216514 | single protein format |
| CHEMBL5091825 |  |
IC50 | = | 144.0 | nM | 485.27 | OCCOCc1cn(CCNc2nonc2/C(=N/O)Nc2ccc(F)c(Br)c2)nn1 | Homo sapiens | CHEMBL5057984 | single protein format |
| CHEMBL4472697 |  |
IC50 | = | 280.0 | nM | 479.25 | CCOP(=O)(CC)NCCNc1nonc1/C(=N/O)Nc1ccc(F)c(Br)c1 | Homo sapiens | CHEMBL4408557 | assay format |
| CHEMBL4791168 |  |
IC50 | = | 310.0 | nM | 465.22 | COP(C)(=O)NCCCNc1nonc1/C(=N/O)Nc1ccc(F)c(Br)c1 | Homo sapiens | CHEMBL4734659 | assay format |
| CHEMBL5085580 |  |
IC50 | = | 362.0 | nM | 455.25 | CC(O)c1cn(CCNc2nonc2/C(=N/O)Nc2ccc(F)c(Br)c2)nn1 | Homo sapiens | CHEMBL5057984 | single protein format |
| CHEMBL5221035 |  |
IC50 | = | 387.0 | nM | 545.33 | O=C(NCc1cn(CCNc2nonc2/C(=N/O)Nc2ccc(F)c(Br)c2)nn1)c1ccccn1 | Homo sapiens | CHEMBL5216514 | single protein format |
| CHEMBL432537 |  |
IC50 | = | 450.0 | nM | 293.24 | O=C1c2cc([N+](=O)[O-])ccc2-n2c1nc1ccccc1c2=O | Homo sapiens | CHEMBL3872639 | cell-based format |
| CHEMBL4514196 |  |
IC50 | = | 490.0 | nM | 451.19 | COP(C)(=O)NCCNc1nonc1/C(=N/O)Nc1ccc(F)c(Br)c1 | Homo sapiens | CHEMBL4408557 | assay format |
| CHEMBL5221037 |  |
IC50 | = | 575.0 | nM | 527.34 | O=C(NCc1cn(CCNc2nonc2/C(=N/O)Nc2cccc(Br)c2)nn1)c1ccccn1 | Homo sapiens | CHEMBL5216514 | single protein format |
| CHEMBL4436582 |  |
IC50 | = | 590.0 | nM | 479.25 | COP(C)(=O)NCCCCNc1nonc1/C(=N/O)Nc1ccc(F)c(Br)c1 | Homo sapiens | CHEMBL4408557 | assay format |
| CHEMBL5082481 |  |
IC50 | = | 689.0 | nM | 511.36 | CC(C)CC(C)(O)c1cn(CCNc2nonc2/C(=N/O)Nc2ccc(F)c(Br)c2)nn1 | Homo sapiens | CHEMBL5057984 | single protein format |
| CHEMBL3545369 |  |
IC50 | = | 710.0 | nM | 438.24 | NS(=O)(=O)NCCNc1nonc1/C(=N/O)Nc1ccc(F)c(Br)c1 | Homo sapiens | CHEMBL4408557 | assay format |
| CHEMBL5090441 |  |
IC50 | = | 726.0 | nM | 469.28 | CC(C)(O)c1cn(CCNc2nonc2/C(=N/O)Nc2ccc(F)c(Br)c2)nn1 | Homo sapiens | CHEMBL5057984 | single protein format |
| CHEMBL5092513 |  |
IC50 | = | 794.0 | nM | 441.22 | OCc1cn(CCNc2nonc2/C(=N/O)Nc2ccc(F)c(Br)c2)nn1 | Homo sapiens | CHEMBL5057984 | single protein format |
| CHEMBL5091241 |  |
IC50 | = | 830.0 | nM | 467.3 | CCCCc1cn(CCNc2nonc2/C(=N/O)Nc2ccc(F)c(Br)c2)nn1 | Homo sapiens | CHEMBL5057984 | single protein format |
| CHEMBL5091415 |  |
IC50 | = | 865.0 | nM | 509.34 | O/N=C(\Nc1ccc(F)c(Br)c1)c1nonc1NCCn1cc(C2(O)CCCCC2)nn1 | Homo sapiens | CHEMBL5057984 | single protein format |
| CHEMBL5091243 |  |
IC50 | = | 930.0 | nM | 499.3 | CC(OCCO)c1cn(CCNc2nonc2/C(=N/O)Nc2ccc(F)c(Br)c2)nn1 | Homo sapiens | CHEMBL5057984 | single protein format |
| CHEMBL5091590 |  |
IC50 | = | 947.0 | nM | 469.28 | CCC(O)c1cn(CCNc2nonc2/C(=N/O)Nc2ccc(F)c(Br)c2)nn1 | Homo sapiens | CHEMBL5057984 | single protein format |
| CHEMBL5093816 |  |
IC50 | = | 958.0 | nM | 469.28 | OCCCc1cn(CCNc2nonc2/C(=N/O)Nc2ccc(F)c(Br)c2)nn1 | Homo sapiens | CHEMBL5057984 | single protein format |