Q6W5P4 | NPSR1_HUMAN | Neuropeptide S receptor (NPSR1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 66~330 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3086835 |  |
IC50 | < | 0.5 | nM | 580.61 | Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCc1ccccc1.O=C([O-])C(F)(F)F | Homo sapiens | CHEMBL3088890 | cell-based format |
| CHEMBL1474387 |  |
IC50 | = | 3.5 | nM | 545.49 | Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccccc1.[Br-] | Homo sapiens | CHEMBL3088889 | cell-based format |
| CHEMBL1210313 |  |
IC50 | = | 6.7 | nM | 467.65 | CCC(C)(CCN1CCOCC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 | Homo sapiens | CHEMBL3088889 | cell-based format |
| CHEMBL1514777 |  |
IC50 | = | 9.1 | nM | 348.41 | Cc1nc2ccccn2c1P(=S)(c1ccccc1)c1ccccc1 | Homo sapiens | CHEMBL3088890 | cell-based format |
| CHEMBL3086834 |  |
IC50 | = | 13.0 | nM | 547.46 | Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C(=O)Cc1ccccc1.[Br-] | Homo sapiens | CHEMBL3088890 | cell-based format |
| CHEMBL1553073 |  |
IC50 | = | 15.0 | nM | 561.53 | Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCc1ccccc1.[Br-] | Homo sapiens | CHEMBL3088890 | cell-based format |
| CHEMBL1315807 |  |
IC50 | = | 16.0 | nM | 533.48 | Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCc1ccccc1.[Br-] | Homo sapiens | CHEMBL3088890 | cell-based format |
| CHEMBL3086833 |  |
IC50 | = | 16.0 | nM | 552.56 | Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1Cc1ccccc1.O=C([O-])C(F)(F)F | Homo sapiens | CHEMBL3088890 | cell-based format |
| CHEMBL469695 |  |
IC50 | = | 25.0 | nM | 445.49 | O=C(NCc1ccc(F)cc1)N1CCN2C(=O)OC(c3ccccc3)(c3ccccc3)C2C1 | Homo sapiens | CHEMBL3088889 | cell-based format |
| CHEMBL1598051 |  |
IC50 | = | 30.0 | nM | 490.35 | Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C.[I-] | Homo sapiens | CHEMBL3088890 | cell-based format |
| CHEMBL3085788 |  |
IC50 | = | 190.0 | nM | 500.6 | COc1ccc(C2c3c(ccc4ccccc34)OC3N=CN(CCN4CCOCC4)C(=N)C32)cc1OC | Homo sapiens | CHEMBL3088898 | single protein format |