Q6PL18 | ATAD2_HUMAN | ATPase family AAA domain-containing protein 2 (ATAD2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00004 | AAA - ATPase family associated with various cellular activities (AAA) | 463~597 | |
| PF00439 | Bromodomain - Bromodomain | 1004~1066 | |
| PF17862 | AAA_lid_3 - AAA+ lid domain | 623~660 |
3D structures mapped by conservation among orthologs
[ Domain: "Bromodomain" // Bromodomain ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5079885 |  |
IC50 | = | 7.0 | nM | 562.69 | Cc1nnc2c(NC3CCN(CC(C)(C)F)CC3)cc(C(=O)N3[C@@H]4c5ccccc5C[C@H]3C(=O)N[C@@H]4C(C)C)nn12 | Homo sapiens | CHEMBL5045652 | assay format |
| CHEMBL5087319 |  |
IC50 | = | 14.0 | nM | 516.65 | Cc1nnc2c(NCCCN3CCCC3)cc(C(=O)N3[C@@H]4c5ccccc5C[C@H]3C(=O)N[C@@H]4C(C)C)nn12 | Homo sapiens | CHEMBL5045652 | assay format |
| CHEMBL5093862 |  |
IC50 | = | 20.0 | nM | 566.66 | Cc1nnc2c(NCCCN3CCC(F)(F)CC3)cc(C(=O)N3[C@@H]4c5ccccc5C[C@H]3C(=O)N[C@@H]4C(C)C)nn12 | Homo sapiens | CHEMBL5045652 | assay format |
| CHEMBL5090369 |  |
IC50 | = | 22.0 | nM | 566.66 | Cc1nnc2c(NC3CCN(CC(C)(F)F)CC3)cc(C(=O)N3[C@@H]4c5ccccc5C[C@H]3C(=O)N[C@@H]4C(C)C)nn12 | Homo sapiens | CHEMBL5045652 | assay format |
| CHEMBL5397368 |  |
IC50 | = | 22.0 | nM | 575.07 | CNC(=O)[C@@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cc(-c2ccc(CN[C@H](C)c3ccc(C)cc3)o2)ccc1Cl | Homo sapiens | CHEMBL5388675 | cell-based format |
| CHEMBL4529901 |  |
IC50 | = | 30.0 | nM | 336.4 | CN1CCN(c2nc(C(=O)c3ccccc3)c3cnn(C)c3n2)CC1 | Homo sapiens | CHEMBL4313206 | cell-based format |
| CHEMBL5086059 |  |
IC50 | = | 41.0 | nM | 474.57 | Cc1nnc2c(NCCCN3CCCC3)cc(C(=O)N3[C@H]4Cc5ccccc5[C@@H]3CNC4=O)nn12 | Homo sapiens | CHEMBL5045652 | assay format |
| CHEMBL5086260 |  |
IC50 | = | 78.0 | nM | 510.47 | C[C@H]1NC(=O)[C@@H]2Cc3ccccc3[C@H]1N2C(=O)c1cn(C)c(=O)c2[nH]c3ccc(OC(F)(F)F)cc3c12 | Homo sapiens | CHEMBL5045652 | assay format |
| CHEMBL5074983 |  |
IC50 | = | 210.0 | nM | 426.48 | C[C@H]1NC(=O)[C@@H]2Cc3ccccc3[C@H]1N2C(=O)c1cn(C)c(=O)c2[nH]c3ccccc3c12 | Homo sapiens | CHEMBL5045652 | assay format |
| CHEMBL5084768 |  |
IC50 | = | 280.0 | nM | 363.38 | Cc1nnc2c(N)cc(C(=O)N3[C@H]4Cc5ccccc5[C@@H]3CNC4=O)nn12 | Homo sapiens | CHEMBL5045652 | assay format |
| CHEMBL5077167 |  |
IC50 | = | 300.0 | nM | 460.54 | Cc1nnc2c(NC3CCN(C)CC3)cc(C(=O)N3[C@H]4Cc5ccccc5[C@@H]3CNC4=O)nn12 | Homo sapiens | CHEMBL5045652 | assay format |
| CHEMBL5092181 |  |
IC50 | = | 370.0 | nM | 459.55 | Cc1nnc2c(NC3CCN(C)CC3)cc(C(=O)N3[C@H]4Cc5ccccc5[C@@H]3CNC4=O)cn12 | Homo sapiens | CHEMBL5045652 | assay format |
| CHEMBL5083025 |  |
IC50 | = | 420.0 | nM | 412.45 | Cn1cc(C(=O)N2[C@H]3Cc4ccccc4[C@@H]2CNC3=O)c2c([nH]c3ccccc32)c1=O | Homo sapiens | CHEMBL5045652 | assay format |
| CHEMBL5093167 |  |
IC50 | = | 440.0 | nM | 454.53 | CC(C)[C@H]1NC(=O)[C@@H]2Cc3ccccc3[C@H]1N2C(=O)c1cn(C)c(=O)c2[nH]c3ccccc3c12 | Homo sapiens | CHEMBL5045652 | assay format |
| CHEMBL3590408 |  |
Ki | = | 20.0 | nM | 525.68 | Cc1cncc(-c2cnc(N[C@@H]3CCN(C)C[C@H]3OCC3CCS(=O)(=O)CC3)c3[nH]c(=O)c(C)cc23)c1 | Homo sapiens | CHEMBL3591374 | single protein format |