Q6P6C2 | ALKB5_HUMAN | RNA demethylase ALKBH5 (ALKBH5)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF13532 | 2OG-FeII_Oxy_2 - 2OG-Fe(II) oxygenase superfamily | 114~274 |
3D structures mapped by conservation among orthologs
[ Domain: "Double-stranded beta-helix" // 2OG-FeII_Oxy_2 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5203605 |  |
IC50 | = | 21.0 | nM | 272.18 | O=C(O)c1cc(O)n(-c2cccc(C(F)(F)F)c2)n1 | Homo sapiens | CHEMBL5115882 | cell-based format |
| CHEMBL5172537 |  |
IC50 | = | 61.0 | nM | 297.11 | Cc1cc(-n2nc(C(=O)O)cc2O)ccc1Br | Homo sapiens | CHEMBL5115882 | cell-based format |
| CHEMBL5205465 |  |
IC50 | = | 396.0 | nM | 286.21 | Cc1ccc(-n2nc(C(=O)O)cc2O)cc1C(F)(F)F | Homo sapiens | CHEMBL5115882 | cell-based format |
| CHEMBL5175898 |  |
IC50 | = | 421.0 | nM | 351.08 | O=C(O)c1cc(O)n(-c2ccc(Br)c(C(F)(F)F)c2)n1 | Homo sapiens | CHEMBL5115882 | cell-based format |
| CHEMBL5186162 |  |
IC50 | = | 559.0 | nM | 297.11 | Cc1ccc(-n2nc(C(=O)O)cc2O)cc1Br | Homo sapiens | CHEMBL5115882 | cell-based format |
| CHEMBL5208142 |  |
IC50 | = | 591.0 | nM | 283.08 | O=C(O)c1cc(O)n(-c2ccc(Br)cc2)n1 | Homo sapiens | CHEMBL5115882 | cell-based format |
| CHEMBL5180828 |  |
IC50 | = | 727.0 | nM | 283.08 | O=C(O)c1cc(O)n(-c2cccc(Br)c2)n1 | Homo sapiens | CHEMBL5115882 | cell-based format |
| CHEMBL4752151 |  |
IC50 | = | 840.0 | nM | 226.25 | O=C(O)CSC(O)C(=O)c1ccccc1 | Homo sapiens | CHEMBL4715235 | single protein format |
| CHEMBL5202184 |  |
IC50 | = | 890.0 | nM | 232.24 | Cc1ccc(-n2nc(C(=O)O)cc2O)cc1C | Homo sapiens | CHEMBL5115882 | cell-based format |
| CHEMBL5188113 |  |
IC50 | = | 920.0 | nM | 327.43 | COc1ccc2ncc(CNCC3(N4CCCC4)COC3)cc2c1 | Homo sapiens | CHEMBL5142378 | single protein format |