Q6P179 | ERAP2_HUMAN | Endoplasmic reticulum aminopeptidase 2 (ERAP2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01433 | Peptidase_M1 - Peptidase family M1 domain | 298~502 | |
| PF11838 | ERAP1_C - ERAP1-like C-terminal domain | 620~938 | |
| PF17900 | Peptidase_M1_N - Peptidase M1 N-terminal domain | 75~263 |
3D structures mapped by conservation among orthologs
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // ERAP1_C ]
[ Domain: "Baculovirus p35 protein-related" // Peptidase_M1_2 ]
[ Domain: "ARM repeat" // ERAP1_C ]
[ Domain: "Metalloproteases ("zincins") catalytic domain" // Peptidase_M1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3416733 |  |
IC50 | = | 11.0 | nM | 512.59 | CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | Homo sapiens | CHEMBL3418221 | cell-based format |
| CHEMBL4101200 |  |
IC50 | = | 37.0 | nM | 455.5 | C#CC[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | Homo sapiens | CHEMBL4024806 | cell-based format |
| CHEMBL4097268 |  |
IC50 | = | 55.0 | nM | 489.55 | CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O | Homo sapiens | CHEMBL4024806 | cell-based format |
| CHEMBL4095882 |  |
IC50 | = | 56.0 | nM | 590.62 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cc(-c2ccc(O)cc2)no1)CP(=O)(O)[C@@H](N)CCc1ccccc1 | Homo sapiens | CHEMBL4024806 | cell-based format |
| CHEMBL4077855 |  |
IC50 | = | 83.0 | nM | 590.62 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cc(-c2ccccc2O)no1)CP(=O)(O)[C@@H](N)CCc1ccccc1 | Homo sapiens | CHEMBL4024806 | cell-based format |
| CHEMBL4091951 |  |
IC50 | = | 96.0 | nM | 397.46 | CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](C)C(N)=O | Homo sapiens | CHEMBL4024806 | cell-based format |
| CHEMBL4099693 |  |
IC50 | = | 109.0 | nM | 473.55 | CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | Homo sapiens | CHEMBL4024806 | cell-based format |
| CHEMBL4081682 |  |
IC50 | = | 118.0 | nM | 439.54 | CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O | Homo sapiens | CHEMBL4024806 | cell-based format |
| CHEMBL4066723 |  |
IC50 | = | 128.0 | nM | 463.52 | CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O | Homo sapiens | CHEMBL4024806 | cell-based format |
| CHEMBL4070078 |  |
IC50 | = | 129.0 | nM | 413.46 | CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](CO)C(N)=O | Homo sapiens | CHEMBL4024806 | cell-based format |
| CHEMBL4089555 |  |
IC50 | = | 144.0 | nM | 423.49 | CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N1CCC[C@H]1C(N)=O | Homo sapiens | CHEMBL4024806 | cell-based format |
| CHEMBL4069425 |  |
IC50 | = | 190.0 | nM | 574.62 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cc(-c2ccccc2)no1)CP(=O)(O)[C@@H](N)CCc1ccccc1 | Homo sapiens | CHEMBL4024806 | cell-based format |
| CHEMBL4077711 |  |
IC50 | = | 211.0 | nM | 473.55 | CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | Homo sapiens | CHEMBL4024806 | cell-based format |
| CHEMBL3416727 |  |
IC50 | = | 237.0 | nM | 451.53 | CCCC[C@H](N)C(=O)Nc1ccc(C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)cc1N | Homo sapiens | CHEMBL3418221 | cell-based format |
| CHEMBL4095735 |  |
IC50 | = | 243.0 | nM | 455.49 | CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](CCC(=O)O)C(N)=O | Homo sapiens | CHEMBL4024806 | cell-based format |
| CHEMBL4069576 |  |
IC50 | = | 246.0 | nM | 563.68 | CC(C)C[C@H](NC(=O)[C@H](CC(c1ccccc1)c1ccccc1)CP(=O)(O)[C@@H](N)CCc1ccccc1)C(N)=O | Homo sapiens | CHEMBL4024806 | cell-based format |
| CHEMBL5195885 |  |
IC50 | = | 250.0 | nM | 578.59 | COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](O)[C@H](N)COc1cc(F)c(F)c(F)c1 | Homo sapiens | CHEMBL5149506 | cell-based format |
| CHEMBL4088020 |  |
IC50 | = | 271.0 | nM | 454.55 | CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O | Homo sapiens | CHEMBL4024806 | cell-based format |
| CHEMBL4074464 |  |
IC50 | = | 412.0 | nM | 565.69 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC12CC3CC(CC(C3)C1)C2)CP(=O)(O)[C@@H](N)CCc1ccccc1 | Homo sapiens | CHEMBL4024806 | cell-based format |
| CHEMBL5195928 |  |
IC50 | = | 460.0 | nM | 573.09 | COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](O)[C@H](N)CCOc1cccc(Cl)c1 | Homo sapiens | CHEMBL5149506 | cell-based format |