Q5XXA6 | ANO1_HUMAN | Anoctamin-1 (ANO1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF04547 | Anoctamin - Calcium-activated chloride channel | 320~926 | |
| PF16178 | Anoct_dimer - Anoctamin, dimerisation domain | 54~317 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4445544 |  |
IC50 | = | 21.0 | nM | 386.76 | Cc1cc(Cl)ccc1OCC(=O)N/N=C/c1ccccc1OC(F)(F)F | Homo sapiens | CHEMBL4310424 | cell-based format |
| CHEMBL5186789 |  |
IC50 | = | 24.0 | nM | 393.8 | O=C(Nc1scc(-c2ccc(Cl)cc2)c1C(=O)O)c1cc(F)ccc1F | Homo sapiens | CHEMBL5123727 | cell-based format |
| CHEMBL1448 |  |
IC50 | = | 28.0 | nM | 327.12 | O=C(Nc1ccc([N+](=O)[O-])cc1Cl)c1cc(Cl)ccc1O | Homo sapiens | CHEMBL5123727 | cell-based format |
| CHEMBL5206041 |  |
IC50 | = | 29.0 | nM | 471.16 | O=C(Nc1scc(-c2ccc(Cl)cc2)c1C(=O)O)c1cc(Cl)ccc1Br | Homo sapiens | CHEMBL5123727 | cell-based format |
| CHEMBL4086165 |  |
IC50 | = | 80.0 | nM | 338.32 | COc1cc(Nc2ccc([N+](=O)[O-])cc2C(=O)O)cc2ccccc12 | Homo sapiens | CHEMBL4015873 | cell-based format |
| CHEMBL4074929 |  |
IC50 | = | 83.0 | nM | 457.34 | Cc1ccccc1NC(=O)c1c(NC(=O)C(F)(F)Br)sc2c1CCCCC2 | Homo sapiens | CHEMBL4015867 | cell-based format |
| CHEMBL4080525 |  |
IC50 | = | 110.0 | nM | 332.79 | COc1ccccc1/C=N/NC(=O)COc1ccc(Cl)cc1C | Homo sapiens | CHEMBL4015868 | cell-based format |
| CHEMBL4104024 |  |
IC50 | = | 150.0 | nM | 508.3 | O=C(Nc1ccc(F)cc1)c1c(NC(=O)C(F)(F)I)sc2c1CCCCC2 | Homo sapiens | CHEMBL4015867 | cell-based format |
| CHEMBL4069503 |  |
IC50 | = | 170.0 | nM | 382.41 | Cc1ccccc1NC(=O)c1c(NC(=O)C(F)(F)F)sc2c1CCCC2 | Homo sapiens | CHEMBL4015867 | cell-based format |
| CHEMBL4071143 |  |
IC50 | = | 180.0 | nM | 412.89 | Cc1ccccc1NC(=O)c1c(NC(=O)C(F)(F)Cl)sc2c1CCCCC2 | Homo sapiens | CHEMBL4015867 | cell-based format |
| CHEMBL4448175 |  |
IC50 | = | 210.0 | nM | 370.76 | Cc1cc(Cl)ccc1OCC(=O)N/N=C/c1ccccc1C(F)(F)F | Homo sapiens | CHEMBL4310424 | cell-based format |
| CHEMBL4090522 |  |
IC50 | = | 220.0 | nM | 382.41 | Cc1ccc(NC(=O)c2c(NC(=O)C(F)(F)F)sc3c2CCCC3)cc1 | Homo sapiens | CHEMBL4015867 | cell-based format |
| CHEMBL4095338 |  |
IC50 | = | 230.0 | nM | 490.31 | O=C(Nc1ccccc1)c1c(NC(=O)C(F)(F)I)sc2c1CCCCC2 | Homo sapiens | CHEMBL4015867 | cell-based format |
| CHEMBL4074900 |  |
IC50 | = | 230.0 | nM | 443.31 | O=C(Nc1ccccc1)c1c(NC(=O)C(F)(F)Br)sc2c1CCCCC2 | Homo sapiens | CHEMBL4015867 | cell-based format |
| CHEMBL5186589 |  |
IC50 | = | 270.0 | nM | 426.71 | O=C(Nc1scc(-c2ccc(Cl)cc2)c1C(=O)O)c1cc(Cl)ccc1Cl | Homo sapiens | CHEMBL5123727 | cell-based format |
| CHEMBL3134585 |  |
IC50 | = | 300.0 | nM | 382.41 | O=C(Nc1ccccc1)c1c(NC(=O)C(F)(F)F)sc2c1CCCCC2 | Homo sapiens | CHEMBL4015867 | cell-based format |
| CHEMBL4515829 |  |
IC50 | = | 300.0 | nM | 400.78 | C/C(=N\NC(=O)COc1ccc(Cl)cc1C)c1ccccc1OC(F)(F)F | Homo sapiens | CHEMBL4310424 | cell-based format |
| CHEMBL4099581 |  |
IC50 | = | 320.0 | nM | 400.4 | O=C(Nc1ccc(F)cc1)c1c(NC(=O)C(F)(F)F)sc2c1CCCCC2 | Homo sapiens | CHEMBL4015867 | cell-based format |
| CHEMBL4091961 |  |
IC50 | = | 370.0 | nM | 438.35 | O=C(Nc1ccccc1OC(F)(F)F)c1c(NC(=O)C(F)(F)F)sc2c1CCC2 | Homo sapiens | CHEMBL4015867 | cell-based format |
| CHEMBL4082703 |  |
IC50 | = | 370.0 | nM | 368.38 | O=C(Nc1ccccc1)c1c(NC(=O)C(F)(F)F)sc2c1CCCC2 | Homo sapiens | CHEMBL4015867 | cell-based format |