Q5VT25 | MRCKA_HUMAN | Serine/threonine-protein kinase MRCK alpha (CDC42BPA)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 77~343 | |
| PF00130 | C1_1 - Phorbol esters/diacylglycerol binding domain (C1 domain) | 1013~1063 | |
| PF00433 | Pkinase_C - Protein kinase C terminal domain | 362~404 | |
| PF00780 | CNH - CNH domain | 1238~1494 | |
| PF08826 | DMPK_coil - DMPK coiled coil domain like | 881~941 | |
| PF15796 | KELK - KELK-motif containing domain of MRCK Ser/Thr protein kinase | 529~608 | |
| PF25346 | PH_MRCK - MRCK kinase PH domain | 1076~1202 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3218297 |  |
IC50 | = | 2.87 | nM | 422.49 | CS(=O)(=O)O.O=C(NCc1cccc(O)c1)Nc1nc(-c2ccncc2)cs1 | Homo sapiens | CHEMBL3224488 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 5.35 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328508 | single protein format |
| CHEMBL4568087 |  |
IC50 | = | 72.0 | nM | 421.53 | Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 | Homo sapiens | CHEMBL4479702 | assay format |
| CHEMBL3221815 |  |
IC50 | = | 74.0 | nM | 423.47 | COc1ccc2c(c1)C[C@H](C(=O)Nc1ccc(-c3cn[nH]c3)cc1OCCCO)CO2 | Homo sapiens | CHEMBL3226113 | single protein format |
| CHEMBL481545 |  |
IC50 | = | 79.0 | nM | 424.48 | CN(C)CCOc1cc(-c2cn[nH]c2)ccc1NC(=O)C1COc2ccc(F)cc2C1 | Homo sapiens | CHEMBL943653 | single protein format |
| CHEMBL3221807 |  |
IC50 | = | 127.0 | nM | 436.51 | COc1ccc2c(c1)C[C@H](C(=O)Nc1ccc(-c3cn[nH]c3)cc1OCCN(C)C)CO2 | Homo sapiens | CHEMBL3226113 | single protein format |
| CHEMBL482336 |  |
IC50 | = | 150.0 | nM | 436.51 | COc1ccc2c(c1)CC(C(=O)Nc1ccc(-c3cn[nH]c3)cc1OCCN(C)C)CO2 | Homo sapiens | CHEMBL943653 | single protein format |
| CHEMBL474425 |  |
IC50 | = | 210.0 | nM | 406.49 | CN(C)CCOc1cc(-c2cn[nH]c2)ccc1NC(=O)C1COc2ccccc2C1 | Homo sapiens | CHEMBL943653 | single protein format |
| CHEMBL1080279 |  |
IC50 | = | 247.0 | nM | 435.55 | COc1cccc(CN(CCN(C)C)C(=O)c2nc3ccc(-c4cn[nH]c4)cc3s2)c1 | Homo sapiens | CHEMBL1099848 | single protein format |
| CHEMBL3221811 |  |
IC50 | = | 261.0 | nM | 448.52 | COc1ccc2c(c1)C[C@H](C(=O)Nc1ccc(-c3cn[nH]c3)cc1O[C@@H]1CCN(C)C1)CO2 | Homo sapiens | CHEMBL3226113 | single protein format |
| CHEMBL3221813 |  |
IC50 | = | 294.0 | nM | 448.52 | COc1ccc2c(c1)C[C@H](C(=O)Nc1ccc(-c3cn[nH]c3)cc1O[C@H]1CCN(C)C1)CO2 | Homo sapiens | CHEMBL3226113 | single protein format |
| CHEMBL1215524 |  |
IC50 | = | 333.0 | nM | 423.49 | CN(C)CCOc1cc(-c2cn[nH]c2)c(F)cc1NC(=O)[C@H]1Cc2ccccc2CN1 | Homo sapiens | CHEMBL1219256 | single protein format |
| CHEMBL1215304 |  |
IC50 | = | 669.0 | nM | 475.59 | COc1ccc2c(c1)C[C@H](C(=O)Nc1ccc(-c3cn[nH]c3)cc1OCC1CCN(C)CC1)NC2 | Homo sapiens | CHEMBL1219256 | single protein format |
| CHEMBL1215526 |  |
IC50 | = | 810.0 | nM | 451.55 | CCN1Cc2ccccc2C[C@@H]1C(=O)Nc1cc(F)c(-c2cn[nH]c2)cc1OCCN(C)C | Homo sapiens | CHEMBL1219256 | single protein format |
| CHEMBL4552628 |  |
IC50 | = | 1000.0 | nM | 425.89 | Cc1sc(C(=O)N[C@@H]2[C@H](N)CCCC2(F)F)cc1-c1cnn2cc(Cl)cnc12 | Homo sapiens | CHEMBL4479702 | assay format |