Q5TCY1 | TTBK1_HUMAN | Tau-tubulin kinase 1 (TTBK1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 35~272 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5182036 |  |
IC50 | = | 1.6 | nM | 337.38 | CC[C@@](C)(O)C#Cc1cc2c(ccn2-c2cc(OC)nc(N)n2)cn1 | Homo sapiens | CHEMBL5156817 | single protein format |
| CHEMBL5283456 |  |
IC50 | = | 2.3 | nM | 307.36 | CC[C@](C)(O)C#Cc1cc2c(ccn2-c2ccnc(N)n2)cn1 | Homo sapiens | CHEMBL5236876 | single protein format |
| CHEMBL5268795 |  |
IC50 | = | 2.3 | nM | 333.4 | CC(C)(O)C#Cc1cc2c(cn1)c(C1CC1)cn2-c1ccnc(N)n1 | Homo sapiens | CHEMBL5236876 | single protein format |
| CHEMBL5280210 |  |
IC50 | = | 2.7 | nM | 337.38 | CC[C@](C)(O)C#Cc1cc2c(ccn2-c2cc(OC)nc(N)n2)cn1 | Homo sapiens | CHEMBL5236876 | single protein format |
| CHEMBL5272364 |  |
IC50 | = | 2.8 | nM | 295.35 | CC(C)(O)C#Cc1cc2c(cn1)CCN2c1ccnc(N)n1 | Homo sapiens | CHEMBL5236876 | single protein format |
| CHEMBL5279863 |  |
IC50 | = | 7.8 | nM | 377.45 | CC(C)(O)C#Cc1cc2c(cn1)c(C1CCOCC1)cn2-c1ccnc(N)n1 | Homo sapiens | CHEMBL5236876 | single protein format |
| CHEMBL5282072 |  |
IC50 | = | 9.8 | nM | 293.33 | CC(C)(O)C#Cc1cc2c(ccn2-c2ccnc(N)n2)cn1 | Homo sapiens | CHEMBL5236876 | single protein format |
| CHEMBL5268080 |  |
IC50 | = | 10.0 | nM | 337.38 | CC[C@](C)(O)C#Cc1cc2c(ccn2-c2nc(N)ncc2OC)cn1 | Homo sapiens | CHEMBL5236876 | single protein format |
| CHEMBL5273263 |  |
IC50 | = | 18.0 | nM | 308.35 | CC[C@](C)(O)C#Cc1cc2c(cn1)cnn2-c1ccnc(N)n1 | Homo sapiens | CHEMBL5236876 | single protein format |
| CHEMBL5271137 |  |
IC50 | = | 18.0 | nM | 390.49 | CN1CCC[C@@H](c2cn(-c3ccnc(N)n3)c3cc(C#CC(C)(C)O)ncc23)C1 | Homo sapiens | CHEMBL5236876 | single protein format |
| CHEMBL5282902 |  |
IC50 | = | 20.0 | nM | 321.38 | CC[C@](C)(O)C#Cc1cc2c(ccn2-c2cc(C)nc(N)n2)cn1 | Homo sapiens | CHEMBL5236876 | single protein format |
| CHEMBL5290581 |  |
IC50 | = | 32.0 | nM | 378.44 | CC(C)(O)C#Cc1cc2c(ccn2-c2ccnc(N)n2)c(N2CCOCC2)n1 | Homo sapiens | CHEMBL5236876 | single protein format |
| CHEMBL5274162 |  |
IC50 | = | 37.0 | nM | 307.36 | CC[C@](C)(O)C#Cc1cc2c(ccn2-c2cc(N)ncn2)cn1 | Homo sapiens | CHEMBL5236876 | single protein format |
| CHEMBL5280803 |  |
IC50 | = | 39.0 | nM | 322.37 | COc1cc2ccn(-c3ccnc(N)n3)c2cc1C#CC(C)(C)O | Homo sapiens | CHEMBL5236876 | single protein format |
| CHEMBL5288487 |  |
IC50 | = | 57.0 | nM | 323.36 | COc1nc(C#CC(C)(C)O)cc2c1ccn2-c1ccnc(N)n1 | Homo sapiens | CHEMBL5236876 | single protein format |
| CHEMBL5278744 |  |
IC50 | = | 60.0 | nM | 294.32 | CC(C)(O)C#Cc1cc2c(cn1)cnn2-c1ccnc(N)n1 | Homo sapiens | CHEMBL5236876 | single protein format |
| CHEMBL5274528 |  |
IC50 | = | 86.0 | nM | 310.33 | CC(C)(O)C#Cc1cc2c(ccn2-c2ccnc(N)n2)cc1F | Homo sapiens | CHEMBL5236876 | single protein format |
| CHEMBL5193906 |  |
IC50 | = | 120.0 | nM | 431.34 | CC1(N)CCN(Cc2ccn3ncnc(Nc4cc(O)cc(Br)c4)c23)CC1 | Homo sapiens | CHEMBL5156814 | single protein format |
| CHEMBL4528881 |  |
IC50 | = | 120.0 | nM | 431.34 | CC1(N)CCC(Nc2ccn3ncnc(Nc4cc(O)cc(Br)c4)c23)CC1 | Homo sapiens | CHEMBL4326705 | single protein format |
| CHEMBL5279159 |  |
IC50 | = | 185.0 | nM | 293.33 | CC(C)(O)C#Cc1ccc2[nH]nc(-c3ccnc(N)n3)c2c1 | Homo sapiens | CHEMBL5236876 | single protein format |