Q5TC84 | OGRL1_HUMAN | Opioid growth factor receptor-like protein 1 (OGFRL1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF04664 | OGFr_N - Opioid growth factor receptor (OGFr) conserved region | 115~319 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3961680 |  |
Ki | = | 0.22 | nM | 519.69 | NC1(C(=O)O)CN(c2nc3ccccc3n([C@H]3C[C@H]4CCC[C@@H](C3)N4[C@@H]3C[C@@H]4CCCC[C@@H](C4)C3)c2=O)C1 | Homo sapiens | CHEMBL3888259 | assay format |
| CHEMBL3894898 |  |
Ki | = | 0.26 | nM | 359.52 | CN(C)C1(c2ccccc2)CCC2(CC1)NCCc1c2[nH]c2ccccc12 | Homo sapiens | CHEMBL3887215 | cell membrane format |
| CHEMBL3959398 |  |
Ki | = | 0.3 | nM | 360.5 | CN(C)C1(c2ccccc2)CCC2(CC1)OCCc1c2[nH]c2ccccc12 | Homo sapiens | CHEMBL3887215 | cell membrane format |
| CHEMBL3969279 |  |
Ki | = | 0.34 | nM | 547.74 | CN(C)C1(C(=O)O)CN(c2nc3ccccc3n([C@H]3C[C@H]4CCC[C@@H](C3)N4[C@@H]3C[C@@H]4CCCC[C@@H](C4)C3)c2=O)C1 | Homo sapiens | CHEMBL3888259 | assay format |
| CHEMBL3894557 |  |
Ki | = | 0.5 | nM | 373.54 | CC1Cc2c([nH]c3ccccc23)C2(CCC(c3ccccc3)(N(C)C)CC2)N1 | Homo sapiens | CHEMBL3887215 | cell membrane format |
| CHEMBL3704630 |  |
Ki | = | 0.8 | nM | 474.69 | O=C1CC[C@@H](Cc2nc3ccccc3n2[C@H]2C[C@H]3CCC[C@@H](C2)N3[C@@H]2C[C@@H]3CCCC[C@@H](C3)C2)N1 | Homo sapiens | CHEMBL3705777 | assay format |
| CHEMBL4115318 |  |
Ki | = | 0.89 | nM | 516.69 | CC12C[C@H]3C[C@@H](N4[C@@H]5CCC[C@H]4C[C@@H](n4c(=O)c(N6CC[C@@H]6C(=O)O)nc6ccccc64)C5)C[C@@H]1C[C@@H]2C3 | Homo sapiens | CHEMBL3888259 | assay format |
| CHEMBL3892859 |  |
Ki | = | 0.9 | nM | 417.55 | COC(=O)C1Cc2c([nH]c3ccccc23)C2(CCC(c3ccccc3)(N(C)C)CC2)N1 | Homo sapiens | CHEMBL3887215 | cell membrane format |
| CHEMBL3704619 |  |
Ki | = | 0.92 | nM | 485.68 | COc1cnc(-c2nc3ccccc3n2[C@H]2C[C@H]3CCC[C@@H](C2)N3[C@@H]2C[C@@H]3CCCC[C@@H](C3)C2)cn1 | Homo sapiens | CHEMBL3705777 | assay format |
| CHEMBL3903565 |  |
Ki | = | 1.03 | nM | 518.7 | C[C@@H]1C[C@@H]2C[C@H](C1)C[C@@H](N1[C@@H]3CCC[C@H]1C[C@@H](n1c(=O)c(N4CC(CC(=O)O)C4)nc4ccccc41)C3)C2 | Homo sapiens | CHEMBL3888259 | assay format |
| CHEMBL3966641 |  |
Ki | = | 1.1 | nM | 373.54 | CN(C)C1(Cc2ccccc2)CCC2(CC1)NCCc1c2[nH]c2ccccc12 | Homo sapiens | CHEMBL3887215 | cell membrane format |
| CHEMBL3647962 |  |
Ki | = | 1.1 | nM | 449.6 | C[C@@H]1C[C@@H]2C[C@H](C1)C[C@@H](N1[C@@H]3CCC[C@H]1C[C@@H](n1c(=O)c(C(=O)O)nc4ccccc41)C3)C2 | Homo sapiens | CHEMBL3887298 | cell-based format |
| CHEMBL3890825 |  |
Ki | = | 1.1 | nM | 419.54 | CC(=O)N1CCc2c([nH]c3cc(F)ccc23)C12CCC(c1ccccc1)(N(C)C)CC2 | Homo sapiens | CHEMBL3887215 | cell membrane format |
| CHEMBL3704618 |  |
Ki | = | 1.15 | nM | 455.65 | c1ccc2c(c1)nc(-c1cnccn1)n2[C@H]1C[C@H]2CCC[C@@H](C1)N2[C@@H]1C[C@@H]2CCCC[C@@H](C2)C1 | Homo sapiens | CHEMBL3705777 | assay format |
| CHEMBL3961861 |  |
Ki | = | 1.2 | nM | 378.49 | CN(C)C1(c2cccc(F)c2)CCC2(CC1)OCCc1c2[nH]c2ccccc12 | Homo sapiens | CHEMBL3887215 | cell membrane format |
| CHEMBL3909041 |  |
Ki | = | 1.2 | nM | 374.53 | CC1Cc2c([nH]c3ccccc23)C2(CCC(c3ccccc3)(N(C)C)CC2)O1 | Homo sapiens | CHEMBL3887215 | cell membrane format |
| CHEMBL3913056 |  |
Ki | = | 1.32 | nM | 518.7 | O=C(O)CC1CN(c2nc3ccccc3n([C@H]3C[C@H]4CCC[C@@H](C3)N4[C@@H]3C[C@@H]4CCCC[C@@H](C4)C3)c2=O)C1 | Homo sapiens | CHEMBL3888259 | assay format |
| CHEMBL3954763 |  |
Ki | = | 1.4 | nM | 377.51 | CN(C)C1(c2ccccc2)CCC2(CC1)NCCc1c2[nH]c2ccc(F)cc12 | Homo sapiens | CHEMBL3887215 | cell membrane format |
| CHEMBL3698827 |  |
Ki | = | 1.4 | nM | 449.6 | CC1(C)[C@H]2CC[C@@H](CCN3[C@@H]4CC[C@H]3C[C@@H](n3c(=O)c(C(=O)O)nc5ccccc53)C4)[C@@H]1C2 | Homo sapiens | CHEMBL3887029 | assay format |
| CHEMBL3698900 |  |
Ki | = | 1.4 | nM | 437.58 | O=C(O)c1nc2ccccc2n([C@H]2C[C@H]3CCC[C@@H](C2)N3C2CCCCCCCC2)c1=O | Homo sapiens | CHEMBL3887029 | assay format |