ProtHub

Q5S007 | LRRK2_HUMAN | Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)

Pfam Domain Table

Accession	Domain	Range
PF00069	Pkinase - Protein kinase domain	1885~2129
PF08477	Roc - Ras of Complex, Roc, domain of DAPkinase	1336~1455
PF13855	LRR_8 - Leucine rich repeat	1012~1070
PF16095	COR-A - C-terminal of Roc, COR-A domain	1545~1671
PF23744	ARM_LRRK2 - LRRK2 ARM repeat	17~649
PF23745	ANK_LRRK2 - LRRK2 ANK repeat	679~808
PF23748	Beta-prop_LRRK2 - LRRK2 beta propeller	2139~2496
PF25497	COR-B - C-terminal of Roc, COR-B domain	1689~1858

3D structures mapped by conservation among orthologs

[ Alpha Fold Model ] (go)

Known binders annotated in ChEMBL

IC50 CSV Ki CSV

Only the first 20 rows are shown.

molecule_chembl_id	assay_type	relation	value	unit	mol_wt	smiles	organism	assay_chembl_id	bao_label
CHEMBL5088471	IC50	<	0.08	nM	420.9	N#CC1(c2ccc3cnc(Nc4cnn(C5CCOCC5)c4Cl)nc3c2)CC12CC2	Homo sapiens	CHEMBL5044129	single protein format
CHEMBL5405380	IC50	<	0.08	nM	435.57	Cc1cc2cnc(NC(=O)C3CC34CC4)cc2cc1C1CCN([C@]2(C)COC[C@@H]2O)CC1	Homo sapiens	CHEMBL5374369	single protein format
CHEMBL5407732	IC50	<	0.08	nM	429.95	C[C@@]1(N2CCC(c3cc4cc(NC(=O)C5CC5)ncc4cc3Cl)CC2)COC[C@@H]1O	Homo sapiens	CHEMBL5374369	single protein format
CHEMBL5433289	IC50	<	0.08	nM	488.03	CC(C)(O)[C@H]1C[C@H]1C(=O)Nc1cc2cc(C3CCN([C@]4(C)COC[C@@H]4O)CC3)c(Cl)cc2cn1	Homo sapiens	CHEMBL5374369	single protein format
CHEMBL5422978	IC50	=	0.11	nM	502.06	COC(C)(C)[C@@H]1C[C@H]1C(=O)Nc1cc2cc(C3CCN([C@]4(C)COC[C@@H]4O)CC3)c(Cl)cc2cn1	Homo sapiens	CHEMBL5374369	single protein format
CHEMBL5396547	IC50	=	0.2	nM	500.04	C[C@@]1(N2CCC(c3cc4cc(NC(=O)[C@H]5CC56CCOCC6)ncc4cc3Cl)CC2)COC[C@@H]1O	Homo sapiens	CHEMBL5374369	single protein format
CHEMBL5267350	IC50	=	0.3	nM	388.48	C[C@@H]1CN(c2cc(-c3n[nH]c4ccc(-c5cnn(C)c5)cc34)ccn2)C[C@H](C)O1	Homo sapiens	CHEMBL5239655	single protein format
CHEMBL5270706	IC50	=	0.3	nM	500.57	CC1=C(C(=O)Nc2ccc3[nH]nc(-c4ccnc(N5CCOCC5)c4)c3c2)C(C)(C)n2nnnc2N1C	Homo sapiens	CHEMBL5246745	single protein format
CHEMBL5408287	IC50	=	0.4	nM	501.03	C[C@@]1(N2CCN(c3cc4cc(NC(=O)[C@H]5CC56CCOCC6)ncc4cc3Cl)CC2)COC[C@@H]1O	Homo sapiens	CHEMBL5374369	single protein format
CHEMBL5436466	IC50	=	0.4	nM	342.36	N#Cc1ccc2c(c1)CC[C@@H]2Oc1ccc2[nH]nc(-c3cnco3)c2c1	Homo sapiens	CHEMBL5369083	single protein format
CHEMBL5419587	IC50	=	0.5	nM	510.04	Cn1cc([C@H]2C[C@@H]2C(=O)Nc2cc3cc(C4CCN([C@]5(C)COC[C@@H]5O)CC4)c(Cl)cc3cn2)cn1	Homo sapiens	CHEMBL5374369	single protein format
CHEMBL5288427	IC50	=	0.53	nM	426.44	CC1=C(C(=O)Nc2ccc3[nH]nc(-c4nc5ccccc5[nH]4)c3c2)Cn2nnnc2N1C	Homo sapiens	CHEMBL5246745	single protein format
CHEMBL5082563	IC50	<	0.6	nM	477.37	FC1CN(C2COC2)CCC1c1cc2nc(Nc3cnn(C4CC4)c3Cl)ncc2cc1Cl	Homo sapiens	CHEMBL5044129	single protein format
CHEMBL5090739	IC50	<	0.6	nM	459.38	Clc1cc2cnc(Nc3cnn(C4CC4)c3Cl)nc2cc1C1CCN(C2COC2)CC1	Homo sapiens	CHEMBL5044129	single protein format
CHEMBL5085777	IC50	<	0.6	nM	400.49	Cc1c(Nc2ncc3ccc(C4(C#N)CC45CC5)cc3n2)cnn1C1CCOCC1	Homo sapiens	CHEMBL5044129	single protein format
CHEMBL5078277	IC50	<	0.6	nM	408.46	Cc1c(Nc2ncc3ccc(N4C(=O)OC[C@@H]4C)cc3n2)cnn1C1CCOCC1	Homo sapiens	CHEMBL5044129	single protein format
CHEMBL5070231	IC50	<	0.6	nM	513.35	FC1CN(C2COC2)CCC1c1cc2nc(Nc3cnn(C4CC4(F)F)c3Cl)ncc2cc1Cl	Homo sapiens	CHEMBL5044129	single protein format
CHEMBL5079796	IC50	<	0.6	nM	545.37	FC1CN(C2COCC2F)CCC1c1cc2nc(Nc3cnn(C4CC4(F)F)c3Cl)ncc2cc1Cl	Homo sapiens	CHEMBL5044129	single protein format
CHEMBL5076397	IC50	<	0.6	nM	543.38	O[C@H]1COC[C@H]1N1CC[C@@H](c2cc3nc(Nc4cnn([C@@H]5CC5(F)F)c4Cl)ncc3cc2Cl)[C@H](F)C1	Homo sapiens	CHEMBL5044129	single protein format
CHEMBL4098447	IC50	<	0.6	nM	360.42	Cn1cc(-c2ccc3[nH]nc(-c4ccnc(N5CCOCC5)c4)c3c2)cn1	Homo sapiens	CHEMBL4010109	assay format

Pfam Domain Table

[ Domain: "8-bladed" // ANAPC4_WD40_6 ]

[ Domain: "8-bladed" // ANAPC4_WD40_4 ]

[ Domain: "P-loop containing nucleoside triphosphate hydrolases" // Ras_1 ]