Q5JUK3 | KCNT1_HUMAN | Potassium channel subfamily T member 1 (KCNT1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF03493 | BK_channel_a - Calcium-activated BK potassium channel alpha subunit | 485~579 | |
| PF07885 | Ion_trans_2 - Ion channel | 260~327 | |
| PF22614 | Slo-like_RCK - Calcium-activated potassium channel slowpoke-like RCK domain | 351~470 | |
| PF22614 | Slo-like_RCK - Calcium-activated potassium channel slowpoke-like RCK domain | 780~900 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4763955 |  |
IC50 | = | 16.0 | nM | 406.37 | C[C@H](NC(=O)c1cc(C(F)(F)F)nn1C)c1nc(-c2ccnc(C3CC3)c2)no1 | Homo sapiens | CHEMBL4714778 | cell-based format |
| CHEMBL4788669 |  |
IC50 | = | 27.0 | nM | 396.33 | COc1cc(-c2noc([C@H](C)NC(=O)c3cc(C(F)(F)F)nn3C)n2)ccn1 | Homo sapiens | CHEMBL4714778 | cell-based format |
| CHEMBL4741793 |  |
IC50 | = | 40.0 | nM | 434.3 | C[C@H](NC(=O)c1cc(C(F)(F)F)nn1C)c1nc(-c2ccnc(C(F)(F)F)c2)no1 | Homo sapiens | CHEMBL4714778 | cell-based format |
| CHEMBL4754084 |  |
IC50 | = | 61.0 | nM | 416.31 | C[C@H](NC(=O)c1cc(C(F)(F)F)nn1C)c1nc(-c2ccnc(C(F)F)c2)no1 | Homo sapiens | CHEMBL4714778 | cell-based format |
| CHEMBL4783741 |  |
IC50 | = | 136.0 | nM | 383.31 | C[C@H](NC(=O)c1cc(C(F)(F)F)nn1C)c1nc(-c2cccc(F)c2)no1 | Homo sapiens | CHEMBL4714778 | cell-based format |
| CHEMBL4786255 |  |
IC50 | = | 165.0 | nM | 380.33 | Cc1cc(-c2noc([C@H](C)NC(=O)c3cc(C(F)(F)F)nn3C)n2)ccn1 | Homo sapiens | CHEMBL4714778 | cell-based format |
| CHEMBL4793291 |  |
IC50 | = | 167.0 | nM | 351.41 | Cc1cccc(-c2noc([C@H](C)NC(=O)c3cc(C4CC4)nn3C)n2)c1 | Homo sapiens | CHEMBL4714778 | cell-based format |
| CHEMBL4793279 |  |
IC50 | = | 195.0 | nM | 395.35 | CNc1cc(-c2noc([C@H](C)NC(=O)c3cc(C(F)(F)F)nn3C)n2)ccn1 | Homo sapiens | CHEMBL4714778 | cell-based format |
| CHEMBL4750925 |  |
IC50 | = | 322.0 | nM | 410.36 | COCc1cc(-c2noc([C@H](C)NC(=O)c3cc(C(F)(F)F)nn3C)n2)ccn1 | Homo sapiens | CHEMBL4714778 | cell-based format |
| CHEMBL4783466 |  |
IC50 | = | 335.0 | nM | 339.4 | CCc1cc(C(=O)N[C@@H](C)c2nc(-c3cccc(C)c3)no2)n(C)n1 | Homo sapiens | CHEMBL4714778 | cell-based format |
| CHEMBL4795194 |  |
IC50 | = | 454.0 | nM | 409.37 | C[C@H](NC(=O)c1cc(C(F)(F)F)nn1C)c1nc(-c2ccnc(N(C)C)c2)no1 | Homo sapiens | CHEMBL4714778 | cell-based format |
| CHEMBL4743249 |  |
IC50 | = | 505.0 | nM | 410.36 | COc1cc(-c2noc([C@H](C)NC(=O)c3cc(C(F)(F)F)nn3C)n2)cc(C)n1 | Homo sapiens | CHEMBL4714778 | cell-based format |
| CHEMBL4781553 |  |
IC50 | = | 573.0 | nM | 435.41 | C[C@H](NC(=O)c1cc(C(F)(F)F)nn1C)c1nc(-c2ccnc(N3CCCC3)c2)no1 | Homo sapiens | CHEMBL4714778 | cell-based format |
| CHEMBL4745211 |  |
IC50 | = | 744.0 | nM | 424.38 | CO[C@@H](C)c1cc(-c2noc([C@H](C)NC(=O)c3cc(C(F)(F)F)nn3C)n2)ccn1 | Homo sapiens | CHEMBL4714778 | cell-based format |
| CHEMBL4758890 |  |
IC50 | = | 778.0 | nM | 424.38 | CO[C@H](C)c1cc(-c2noc([C@H](C)NC(=O)c3cc(C(F)(F)F)nn3C)n2)ccn1 | Homo sapiens | CHEMBL4714778 | cell-based format |
| CHEMBL4779088 |  |
IC50 | = | 977.0 | nM | 379.34 | Cc1cccc(-c2nc(C(C)NC(=O)c3cc(C(F)(F)F)nn3C)no2)c1 | Homo sapiens | CHEMBL4714778 | cell-based format |