Q5BJF2 | SGMR2_HUMAN | Sigma intracellular receptor 2 (TMEM97)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF05241 | EBP - EXPERA (EXPanded EBP superfamily) | 43~161 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4792070 |  |
IC50 | = | 45.0 | nM | 359.99 | CCN(C/C=C\c1ccc(C2CCCCC2)c(Cl)c1)C1CCCCC1 | Homo sapiens | CHEMBL5225134 | single protein format |
| CHEMBL5440801 |  |
IC50 | = | 227.1 | nM | 334.46 | Cc1ccc(CCCN2CC3(CC(=O)N(c4ccccc4)C3)C2)cc1 | Homo sapiens | CHEMBL5348726 | single protein format |
| CHEMBL4519018 |  |
IC50 | = | 418.0 | nM | 309.25 | CN1C2CCCC1CC(Nc1ccccc1Br)C2 | Homo sapiens | CHEMBL5325665 | single protein format |
| CHEMBL61479 |  |
Ki | = | 0.12 | nM | 454.59 | Fc1ccc(-n2cc(CCCCN3CCC4(CC3)OCc3ccccc34)c3ccccc32)cc1 | Homo sapiens | CHEMBL4148656 | single protein format |
| CHEMBL227126 |  |
Ki | = | 0.26 | nM | 585.44 | COc1cc2c(cc1OC)CN(CCCCNC(=O)c1cc(I)cc(OC)c1OCC[18F])CC2 | Homo sapiens | CHEMBL4148656 | single protein format |
| CHEMBL53325 |  |
Ki | = | 0.34 | nM | 370.58 | COc1cccc2c1CCCC2CCCN1CCN(C2CCCCC2)CC1 | Homo sapiens | CHEMBL4148656 | single protein format |
| CHEMBL5426155 |  |
Ki | = | 0.43 | nM | 395.5 | COc1cc2c(cc1OC)CN(CCCCn1c(=O)n(C)c3ccccc31)CC2 | Homo sapiens | CHEMBL5324497 | single protein format |
| CHEMBL4853196 |  |
Ki | = | 0.44 | nM | 380.32 | COc1cc2c(cc1OC)CN([C@H](C)CCc1ccc(Cl)c(Cl)c1)C2 | Homo sapiens | CHEMBL4839716 | single protein format |
| CHEMBL4647871 |  |
Ki | = | 0.59 | nM | 411.59 | CC1(C)SCC(CN2CCC(Cc3ccccc3)CC2)S1.O=C(O)C(=O)O | Homo sapiens | CHEMBL4616323 | single protein format |
| CHEMBL5395523 |  |
Ki | = | 1.0 | nM | 453.59 | CCc1ncc(-c2cc(C)no2)c(C2CCN(CC(=O)N3CCC4(CCOC4)CC3)CC2)n1 | Homo sapiens | CHEMBL5324504 | cell membrane format |
| CHEMBL5418939 |  |
Ki | = | 1.0 | nM | 411.51 | Cc1cc(-c2cnc(C3CC3)nc2C2CCN(CC(=O)N3CCOCC3)CC2)on1 | Homo sapiens | CHEMBL5324504 | cell membrane format |
| CHEMBL332701 |  |
Ki | = | 1.6 | nM | 366.53 | COc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1 | Homo sapiens | CHEMBL5110026 | single protein format |
| CHEMBL227072 |  |
Ki | = | 2.0 | nM | 443.55 | COc1cc2c(cc1OC)CN(CCCCNC(=O)c1cc(C)ccc1OCC[18F])CC2 | Homo sapiens | CHEMBL5225136 | single protein format |
| CHEMBL3321792 |  |
Ki | = | 2.2 | nM | 405.97 | OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccccc1F | Homo sapiens | CHEMBL4390736 | cell-based format |
| CHEMBL4577233 |  |
Ki | = | 2.2 | nM | 379.93 | Fc1ccc(SCCCN2CCCN(c3ccc(Cl)cn3)CC2)cc1 | Homo sapiens | CHEMBL4390736 | cell-based format |
| CHEMBL4446729 |  |
Ki | = | 2.7 | nM | 390.89 | O/N=C(/CCCN1CCCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1 | Homo sapiens | CHEMBL4390736 | cell-based format |
| CHEMBL4642427 |  |
Ki | = | 3.0 | nM | 437.63 | O=C(O)C(=O)O.c1ccc(CC2CCN(CC3CSC4(CCCC4)S3)CC2)cc1 | Homo sapiens | CHEMBL4616323 | single protein format |
| CHEMBL5393813 |  |
Ki | = | 3.0 | nM | 447.53 | CCCc1ncc(-c2cc(C)no2)c(C2CCN(CC(=O)N3CCC(F)(F)CC3)CC2)n1 | Homo sapiens | CHEMBL5324504 | cell membrane format |
| CHEMBL4633444 |  |
Ki | = | 3.3 | nM | 502.61 | CC1(C)SCC(CN2CCN(Cc3ccccc3)CC2)S1.O=C(O)C(=O)O.O=C(O)C(=O)O | Homo sapiens | CHEMBL4616323 | single protein format |
| CHEMBL5274616 |  |
Ki | = | 3.7 | nM | 317.44 | C1=C(c2c[nH]c3ncccc23)CCN(CCCc2ccccc2)C1 | Homo sapiens | CHEMBL5225134 | single protein format |