Q59H18 | TNI3K_HUMAN | Serine/threonine-protein kinase TNNI3K (TNNI3K)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 463~719 | |
| PF12796 | Ank_2 - Ankyrin repeats (3 copies) | 58~128 | |
| PF12796 | Ank_2 - Ankyrin repeats (3 copies) | 138~232 | |
| PF12796 | Ank_2 - Ankyrin repeats (3 copies) | 310~403 | |
| PF13637 | Ank_4 - Ankyrin repeats (many copies) | 247~287 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3613198 |  |
IC50 | = | 0.7 | nM | 425.31 | CNS(=O)(=O)c1ccc(N(C)C)c(Nc2ncnc3[nH]cc(Br)c23)c1 | Homo sapiens | CHEMBL3616263 | cell-based format |
| CHEMBL3613197 |  |
IC50 | = | 1.6 | nM | 360.44 | CNS(=O)(=O)c1ccc(N(C)C)c(Nc2ncnc3[nH]cc(C)c23)c1 | Homo sapiens | CHEMBL3616263 | cell-based format |
| CHEMBL3613305 |  |
IC50 | = | 6.3 | nM | 467.35 | CNS(=O)(=O)c1ccc(N2CCOCC2)c(Nc2ncnc3[nH]cc(Br)c23)c1 | Homo sapiens | CHEMBL3616263 | cell-based format |
| CHEMBL4094739 |  |
IC50 | = | 8.0 | nM | 482.98 | CCS(=O)(=O)c1ccc(S(=O)(=O)NC)cc1Nc1cc(Nc2ccc(Cl)cn2)ncn1 | Homo sapiens | CHEMBL4024627 | cell-based format |
| CHEMBL4859380 |  |
IC50 | <= | 10.0 | nM | 417.39 | CNc1cc(Oc2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2C)ncn1 | Homo sapiens | CHEMBL4841800 | single protein format |
| CHEMBL4869303 |  |
IC50 | = | 10.0 | nM | 472.25 | CNc1cc(Oc2c(Cl)cc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2Cl)ncn1 | Homo sapiens | CHEMBL4841800 | single protein format |
| CHEMBL3814798 |  |
IC50 | < | 10.0 | nM | 422.9 | CNS(=O)(=O)c1ccc(N2CCOCC2)c(Nc2ncnc3[nH]cc(Cl)c23)c1 | Homo sapiens | CHEMBL3816884 | assay format |
| CHEMBL4091362 |  |
IC50 | <= | 10.0 | nM | 511.03 | CNS(=O)(=O)c1ccc(S(=O)(=O)C(C)(C)C)c(Nc2cc(Nc3ccc(Cl)cn3)ncn2)c1 | Homo sapiens | CHEMBL4024626 | assay format |
| CHEMBL3895839 |  |
IC50 | < | 10.0 | nM | 412.48 | CNS(=O)(=O)c1ccc(N(C)C)c(Nc2ncnc3[nH]cc(-c4ccco4)c23)c1 | Homo sapiens | CHEMBL3861903 | assay format |
| CHEMBL3925896 |  |
IC50 | < | 10.0 | nM | 422.46 | CNS(=O)(=O)c1ccc(N2CCCC(F)(F)C2)c(Nc2ncnc3[nH]ccc23)c1 | Homo sapiens | CHEMBL3861903 | assay format |
| CHEMBL3911058 |  |
IC50 | = | 10.0 | nM | 433.93 | CNS(=O)(=O)c1ccc(N(C)C)c(Nc2ncnc(Nc3ccc(Cl)cc3)n2)c1 | Homo sapiens | CHEMBL3861903 | assay format |
| CHEMBL3814834 |  |
IC50 | = | 10.0 | nM | 417.49 | CNS(=O)(=O)c1ccc(N(C)C)c(Nc2ncnc3cc(OC)cc(OC)c23)c1 | Homo sapiens | CHEMBL3816952 | cell-based format |
| CHEMBL4875220 |  |
IC50 | = | 10.0 | nM | 523.47 | O=C(O)Cc1cccc(Nc2cc(Oc3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)ncn2)c1 | Homo sapiens | CHEMBL4841800 | single protein format |
| CHEMBL4867760 |  |
IC50 | = | 10.0 | nM | 548.57 | O=C(Nc1ccc(Oc2cc(Nc3cccc(CN4CCCC4)c3)ncn2)cc1)Nc1cccc(C(F)(F)F)c1 | Homo sapiens | CHEMBL4841800 | single protein format |
| CHEMBL4102486 |  |
IC50 | <= | 10.0 | nM | 420.88 | CNS(=O)(=O)c1ccc(OC)c(Nc2cc(Nc3ccc(Cl)cn3)ncn2)c1 | Homo sapiens | CHEMBL4024626 | assay format |
| CHEMBL3984331 |  |
IC50 | = | 10.0 | nM | 414.41 | CNS(=O)(=O)c1ccc(N(C)CC(F)(F)F)c(Nc2ncnc3[nH]ccc23)c1 | Homo sapiens | CHEMBL3861903 | assay format |
| CHEMBL4087038 |  |
IC50 | <= | 10.0 | nM | 488.88 | CNS(=O)(=O)c1ccc(OCC(F)(F)F)c(Nc2cc(Nc3ccc(Cl)cn3)ncn2)c1 | Homo sapiens | CHEMBL4024626 | assay format |
| CHEMBL4070430 |  |
IC50 | <= | 10.0 | nM | 497.0 | CNS(=O)(=O)c1ccc(S(=O)(=O)C(C)C)c(Nc2cc(Nc3ccc(Cl)cn3)ncn2)c1 | Homo sapiens | CHEMBL4024626 | assay format |
| CHEMBL3613307 |  |
IC50 | = | 13.0 | nM | 490.51 | CNS(=O)(=O)c1ccc(N(C)C)c(Nc2ncnc3[nH]c(-c4cccc(C(F)(F)F)c4)cc23)c1 | Homo sapiens | CHEMBL3615799 | assay format |
| CHEMBL3814998 |  |
IC50 | = | 13.0 | nM | 486.47 | CCOc1cc2ncnc(Nc3cc(S(=O)(=O)NC)ccc3OCC(F)(F)F)c2cc1OC | Homo sapiens | CHEMBL3816884 | assay format |