Q53GL7 | PAR10_HUMAN | Protein mono-ADP-ribosyltransferase PARP10 (PARP10)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00644 | PARP - Poly(ADP-ribose) polymerase catalytic domain | 829~952 | |
| PF23085 | RRM_PARP14_3 - PARP14, third RRM domain | 13~82 | |
| PF23085 | RRM_PARP14_3 - PARP14, third RRM domain | 182~251 |
3D structures mapped by conservation among orthologs
[ Domain: "RNA-binding domain, RBD" // RRM_1_3 ]
[ Domain: "ADP-ribosylation" // PARP ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5402698 |  |
IC50 | = | 10.8 | nM | 549.36 | O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCn2c(nnc2-c2ccc(Br)o2)C1 | Homo sapiens | CHEMBL5366435 | single protein format |
| CHEMBL5404785 |  |
IC50 | = | 120.0 | nM | 250.28 | COc1ccc(OC)c2c1sc1nnc(N)n12 | Homo sapiens | CHEMBL5318189 | assay format |
| CHEMBL5192839 |  |
IC50 | = | 130.0 | nM | 260.29 | O=c1[nH][nH]c(=O)c2cc(OCC3CCCC3)ccc12 | Homo sapiens | CHEMBL5123560 | single protein format |
| CHEMBL5181947 |  |
IC50 | = | 140.0 | nM | 274.32 | O=c1[nH][nH]c(=O)c2cc(OCC3CCCCC3)ccc12 | Homo sapiens | CHEMBL5123560 | single protein format |
| CHEMBL5200358 |  |
IC50 | = | 150.0 | nM | 286.26 | O=c1[nH][nH]c(=O)c2cc(OCc3ccccc3F)ccc12 | Homo sapiens | CHEMBL5123560 | single protein format |
| CHEMBL5207717 |  |
IC50 | = | 156.0 | nM | 364.43 | CC#Cc1ccc2c(=O)[nH]c(CSc3ccc(C(=O)O)cc3)nc2c1C | Homo sapiens | CHEMBL5124484 | single protein format |
| CHEMBL5200521 |  |
IC50 | = | 160.0 | nM | 274.3 | O=c1[nH][nH]c(=O)c2cc(OCc3ccsc3)ccc12 | Homo sapiens | CHEMBL5123560 | single protein format |
| CHEMBL5187187 |  |
IC50 | = | 160.0 | nM | 246.27 | O=c1[nH][nH]c(=O)c2cc(OCC3CCC3)ccc12 | Homo sapiens | CHEMBL5123560 | single protein format |
| CHEMBL4287262 |  |
IC50 | = | 180.0 | nM | 257.25 | NC(=O)c1ccc(Oc2ccc(C(=O)O)cc2)cc1 | Homo sapiens | CHEMBL4272739 | assay format |
| CHEMBL5431108 |  |
IC50 | = | 180.0 | nM | 204.26 | Cc1ccc2c(c1)sc1nnc(N)n12 | Homo sapiens | CHEMBL5318189 | assay format |
| CHEMBL4208737 |  |
IC50 | = | 230.0 | nM | 245.25 | NC(=O)c1ccc(OCc2ccccc2F)cc1 | Homo sapiens | CHEMBL4272739 | assay format |
| CHEMBL4128574 |  |
IC50 | = | 250.0 | nM | 418.47 | NC(=O)c1ccc(Oc2cccc(C(=O)N3CCC(c4cccc(F)c4)CC3)c2)cc1 | Homo sapiens | CHEMBL4122797 | assay format |
| CHEMBL5186967 |  |
IC50 | = | 290.0 | nM | 205.26 | NC(=O)c1ccc(OCC2CCC2)cc1 | Homo sapiens | CHEMBL5123560 | single protein format |
| CHEMBL5181107 |  |
IC50 | = | 310.0 | nM | 232.24 | O=c1[nH][nH]c(=O)c2cc(OCC3CC3)ccc12 | Homo sapiens | CHEMBL5123560 | single protein format |
| CHEMBL5421878 |  |
IC50 | = | 320.0 | nM | 207.21 | Oc1ccc(O)c2c1sc1nncn12 | Homo sapiens | CHEMBL5318189 | assay format |
| CHEMBL5395820 |  |
IC50 | = | 325.0 | nM | 534.47 | C[C@@H](CN1CC(C(=O)N2CCN(c3ncc(C(F)(F)F)cn3)CC2)C1)Nc1cn[nH]c(=O)c1C(F)(F)F | Homo sapiens | CHEMBL5317578 | cell-based format |
| CHEMBL1438938 |  |
IC50 | = | 329.0 | nM | 256.26 | NC(=O)c1ccc(Oc2ccc(C(N)=O)cc2)cc1 | Homo sapiens | CHEMBL4122805 | assay format |
| CHEMBL521686 |  |
IC50 | = | 350.0 | nM | 434.47 | O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCN(C(=O)C2CC2)CC1 | Homo sapiens | CHEMBL5373904 | cell-based format |
| CHEMBL4125748 |  |
IC50 | = | 390.0 | nM | 434.47 | NC(=O)c1ccc(Oc2cccc(C(=O)N3CCC(O)(c4ccc(F)cc4)CC3)c2)cc1 | Homo sapiens | CHEMBL4122797 | assay format |
| CHEMBL4129789 |  |
IC50 | = | 400.0 | nM | 418.47 | NC(=O)c1ccc(Oc2cccc(C(=O)N3CCC(c4ccc(F)cc4)CC3)c2)cc1 | Homo sapiens | CHEMBL4122797 | assay format |