Q460N5 | PAR14_HUMAN | Protein mono-ADP-ribosyltransferase PARP14 (PARP14)

Pfam Domain Table

AccessionDomainRangeColor
PF00644PARP - Poly(ADP-ribose) polymerase catalytic domain1628~1747
PF01661Macro - Macro domain820~936
PF01661Macro - Macro domain1043~1146
PF01661Macro - Macro domain1245~1346
PF22005WWE_1 - Parp14 WWE domain1529~1600
PF23084KH_PARP14_1 - PARP14, first type I KH domain314~394
PF23085RRM_PARP14_3 - PARP14, third RRM domain227~308
PF23222RRM_PARP14_1 - PAR14-like, first RRM domain9~88
PF23245RRM_PARP14_2 - PARP14, second RRM domain146~225
PF23248KH_PARP14_2 - PARP14, second type I KH domain398~466
PF23249KH_PARP14_3 - PARP14, third type I KH domain471~531
PF23251KH_PARP14_4 - PARP14, fourth type I KH domain534~598
PF23252KH_PARP14_5 - PARP14, fifth type I KH domain600~669
PF23253KH_PARP14_6 - PARP14, sixth type I KH domain670~737
PF23254KH_PARP14_8 - PARP14-like, eighth type I KH domain1454~1519

3D structures mapped by conservation among orthologs

[ Domain: "ADP-ribosylation" // PARP ]

 PyMOL session

[ Domain: "Macro domain-like" // Macro ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL5179405 IC50 = 3.0 nM 378.47 O=c1[nH]c(CS[C@H]2CC[C@H](O)CC2)nc2cc(OCC3CC3)cc(F)c12 Homo sapiens CHEMBL5123577 single protein format
CHEMBL5171039 IC50 = 19.0 nM 376.5 O=c1[nH]c(CSC2CCNCC2)nc2cc(NC3CCCC3)cc(F)c12 Homo sapiens CHEMBL5124487 single protein format
CHEMBL5178541 IC50 = 76.0 nM 332.47 CN1CCC(CNc2nc3sc4c(c3c(=O)[nH]2)CCCC4)CC1 Homo sapiens CHEMBL5124487 single protein format
CHEMBL4068366 IC50 = 160.0 nM 412.88 NC(=O)c1cccc(NC(=O)/C=C\C(=O)N2CCN(c3ccc(Cl)cc3)CC2)c1 Homo sapiens CHEMBL4022061 assay format
CHEMBL4074448 IC50 = 270.0 nM 395.43 NC(=O)c1cccc(NC(=O)/C=C\C(=O)N2CCC(c3ccc(F)cc3)CC2)c1 Homo sapiens CHEMBL4022061 assay format
CHEMBL5180051 IC50 = 300.0 nM 304.42 Cc1cccc2c(=O)[nH]c(CS[C@H]3CC[C@H](O)CC3)nc12 Homo sapiens CHEMBL5124488 single protein format
CHEMBL5404785 IC50 = 300.0 nM 250.28 COc1ccc(OC)c2c1sc1nnc(N)n12 Homo sapiens CHEMBL5318205 assay format
CHEMBL5196898 IC50 = 310.0 nM 312.4 O=c1[nH]c(NCc2ccncc2)nc2sc3c(c12)CCCC3 Homo sapiens CHEMBL5124486 single protein format
CHEMBL4104938 IC50 = 370.0 nM 402.45 CC(C)(C)OC(=O)N1CCN(C(=O)/C=C\C(=O)Nc2cccc(C(N)=O)c2)CC1 Homo sapiens CHEMBL4022061 assay format
CHEMBL4079213 IC50 = 410.0 nM 396.42 NC(=O)c1cccc(NC(=O)/C=C\C(=O)N2CCN(c3ccccc3F)CC2)c1 Homo sapiens CHEMBL4022061 assay format
CHEMBL4104503 IC50 = 450.0 nM 391.47 NC(=O)c1cccc(NC(=O)/C=C\C(=O)N2CCC(Cc3ccccc3)CC2)c1 Homo sapiens CHEMBL4022061 assay format
CHEMBL5205408 IC50 = 490.0 nM 557.59 NC(=O)c1cccc(NC(=O)CCC(=O)NCCc2cn(CCNS(=O)(=O)c3cccc(C(=O)O)c3)nn2)c1 Homo sapiens CHEMBL5124470 assay format
CHEMBL5199759 IC50 = 580.0 nM 443.55 c1ccc(C(OC2CCN(CCCOc3ccc4nncn4n3)CC2)c2ccccc2)cc1 Homo sapiens CHEMBL5124486 single protein format
CHEMBL5191979 IC50 = 610.0 nM 456.59 c1ccc(C(OC2CCN(CCCCNc3ccc4nncn4n3)CC2)c2ccccc2)cc1 Homo sapiens CHEMBL5124487 single protein format
CHEMBL4293771 IC50 = 630.0 nM 306.16 NC(=O)c1ccc(OCc2cccc(Br)c2)cc1 Homo sapiens CHEMBL5057858 single protein format
CHEMBL4080281 IC50 = 650.0 nM 405.5 NC(=O)c1cccc(NC(=O)/C=C\C(=O)N2CCC(CCc3ccccc3)CC2)c1 Homo sapiens CHEMBL4022061 assay format
CHEMBL5431108 IC50 = 650.0 nM 204.26 Cc1ccc2c(c1)sc1nnc(N)n12 Homo sapiens CHEMBL5318205 assay format
CHEMBL4226482 IC50 = 660.0 nM 437.52 N#Cc1cccc(CS(=O)(=O)Nc2ccccc2-c2cccc3c2[nH]c2ccccc23)c1 Homo sapiens CHEMBL4222715 assay format
CHEMBL4085694 IC50 = 690.0 nM 377.44 NC(=O)c1cccc(NC(=O)/C=C\C(=O)N2CCCC(c3ccccc3)C2)c1 Homo sapiens CHEMBL4022061 assay format
CHEMBL4089522 IC50 = 700.0 nM 396.42 NC(=O)c1cccc(NC(=O)/C=C\C(=O)N2CCN(c3ccc(F)cc3)CC2)c1 Homo sapiens CHEMBL4022061 assay format