Q460N3 | PAR15_HUMAN | Protein mono-ADP-ribosyltransferase PARP15 (PARP15)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00644 | PARP - Poly(ADP-ribose) polymerase catalytic domain | 504~676 | |
| PF01661 | Macro - Macro domain | 112~221 | |
| PF01661 | Macro - Macro domain | 322~420 |
3D structures mapped by conservation among orthologs
[ Domain: "ADP-ribosylation" // PARP ]
[ Domain: "Macro domain-like" // Macro ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5404785 |  |
IC50 | = | 120.0 | nM | 250.28 | COc1ccc(OC)c2c1sc1nnc(N)n12 | Homo sapiens | CHEMBL5318190 | assay format |
| CHEMBL5190289 |  |
IC50 | = | 200.0 | nM | 409.4 | Cc1cccc(C(=O)N[C@@H](CNC(=O)c2ccc3c(=O)[nH][nH]c(=O)c3c2)C(N)=O)c1 | Homo sapiens | CHEMBL5124495 | assay format |
| CHEMBL5195249 |  |
IC50 | = | 200.0 | nM | 380.36 | Cc1cccc(C(=O)N[C@H](C(N)=O)C(=O)c2ccc3c(=O)[nH][nH]c(=O)c3c2)c1 | Homo sapiens | CHEMBL5123580 | single protein format |
| CHEMBL3108871 |  |
IC50 | = | 230.0 | nM | 201.25 | O=c1[nH]c2sccc2c2ccccc12 | Homo sapiens | CHEMBL5057864 | assay format |
| CHEMBL5421878 |  |
IC50 | = | 290.0 | nM | 207.21 | Oc1ccc(O)c2c1sc1nncn12 | Homo sapiens | CHEMBL5318190 | assay format |
| CHEMBL5431108 |  |
IC50 | = | 300.0 | nM | 204.26 | Cc1ccc2c(c1)sc1nnc(N)n12 | Homo sapiens | CHEMBL5318190 | assay format |
| CHEMBL5192839 |  |
IC50 | = | 320.0 | nM | 260.29 | O=c1[nH][nH]c(=O)c2cc(OCC3CCCC3)ccc12 | Homo sapiens | CHEMBL5123561 | cell-based format |
| CHEMBL5187187 |  |
IC50 | = | 370.0 | nM | 246.27 | O=c1[nH][nH]c(=O)c2cc(OCC3CCC3)ccc12 | Homo sapiens | CHEMBL5123561 | cell-based format |
| CHEMBL5200358 |  |
IC50 | = | 370.0 | nM | 286.26 | O=c1[nH][nH]c(=O)c2cc(OCc3ccccc3F)ccc12 | Homo sapiens | CHEMBL5123561 | cell-based format |
| CHEMBL5200521 |  |
IC50 | = | 400.0 | nM | 274.3 | O=c1[nH][nH]c(=O)c2cc(OCc3ccsc3)ccc12 | Homo sapiens | CHEMBL5123561 | cell-based format |
| CHEMBL5181947 |  |
IC50 | = | 400.0 | nM | 274.32 | O=c1[nH][nH]c(=O)c2cc(OCC3CCCCC3)ccc12 | Homo sapiens | CHEMBL5123561 | cell-based format |
| CHEMBL5207717 |  |
IC50 | = | 496.0 | nM | 364.43 | CC#Cc1ccc2c(=O)[nH]c(CSc3ccc(C(=O)O)cc3)nc2c1C | Homo sapiens | CHEMBL5124494 | single protein format |
| CHEMBL5187652 |  |
IC50 | = | 510.0 | nM | 423.43 | CNC(=O)[C@H](CNC(=O)c1ccc2c(=O)[nH][nH]c(=O)c2c1)NC(=O)c1cccc(C)c1 | Homo sapiens | CHEMBL5124495 | assay format |
| CHEMBL4089522 |  |
IC50 | = | 520.0 | nM | 396.42 | NC(=O)c1cccc(NC(=O)/C=C\C(=O)N2CCN(c3ccc(F)cc3)CC2)c1 | Homo sapiens | CHEMBL4022069 | single protein format |
| CHEMBL5084343 |  |
IC50 | = | 527.0 | nM | 231.28 | COc1ccc2c(=O)[nH]c3sccc3c2c1 | Homo sapiens | CHEMBL5057857 | assay format |
| CHEMBL5186481 |  |
IC50 | = | 600.0 | nM | 324.15 | NC(=O)c1ccc(OCc2cccc(Br)c2)cc1F | Homo sapiens | CHEMBL5123561 | cell-based format |
| CHEMBL5402584 |  |
IC50 | = | 780.0 | nM | 203.27 | Cc1cc(C)c2c(c1)sc1nncn12 | Homo sapiens | CHEMBL5318190 | assay format |
| CHEMBL5200663 |  |
IC50 | = | 970.0 | nM | 493.43 | NC(=O)[C@H](CNC(=O)c1ccc2c(=O)[nH][nH]c(=O)c2c1)NC(=O)COc1ccc2ccc(=O)oc2c1 | Homo sapiens | CHEMBL5124495 | assay format |