Q3SYC2 | MOGT2_HUMAN | 2-acylglycerol O-acyltransferase 2 (MOGAT2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF03982 | DAGAT - Diacylglycerol acyltransferase | 41~333 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5434664 |  |
IC50 | = | 1.0 | nM | 501.48 | Cc1ccc(-c2cc(-c3ccc(OCCCCCC(F)(F)F)cc3F)[nH]c(=O)c2-c2nnn[nH]2)cc1 | Homo sapiens | CHEMBL5323325 | single protein format |
| CHEMBL2441597 |  |
IC50 | = | 2.0 | nM | 567.49 | Cc1ccc(C2=C(C(=O)Nc3ccno3)C(=O)N[C@@](c3ccc(OCCCC(F)(F)F)cc3)(C(F)(F)F)C2)cc1 | Homo sapiens | CHEMBL2446068 | single protein format |
| CHEMBL3655055 |  |
IC50 | = | 2.0 | nM | 593.77 | C/C=C\CCCCCOc1ccc(NS(=O)(=O)c2ccc3c(c2)CN(C(=O)Nc2ccc(C(C)(C)C)cc2)C3)c(F)c1 | Homo sapiens | CHEMBL3705499 | cell-based format |
| CHEMBL5415437 |  |
IC50 | = | 2.0 | nM | 503.55 | CCc1ccc(-c2cc(-c3ccc(OCCCCCC(F)(F)F)cc3)[nH]c(=O)c2-c2nnn[nH]2)s1 | Homo sapiens | CHEMBL5323325 | single protein format |
| CHEMBL5424834 |  |
IC50 | = | 2.0 | nM | 515.56 | O=c1[nH]c(-c2ccc(OCCCCCC(F)(F)F)cc2)cc(-c2ccc(C3CC3)s2)c1-c1nnn[nH]1 | Homo sapiens | CHEMBL5323325 | single protein format |
| CHEMBL3325734 |  |
IC50 | = | 3.8 | nM | 467.9 | CS(=O)(=O)N[C@@H](c1ccc(CNC[C@H]2COc3cccnc3O2)cc1)C(F)(F)F.Cl | Homo sapiens | CHEMBL3362084 | cell-based format |
| CHEMBL3134097 |  |
IC50 | = | 4.0 | nM | 437.47 | CCc1cc(S(=O)(=O)Nc2ccc(F)cc2F)cc2c1NC(=O)C(C)(CC)NC2=O | Homo sapiens | CHEMBL3135117 | single protein format |
| CHEMBL3639539 |  |
IC50 | = | 4.0 | nM | 593.77 | CC(C)(C)c1ccc(NC(=O)N2Cc3ccc(S(=O)(=O)Nc4ccc(OCCCC5CCCC5)cc4F)cc3C2)cc1 | Homo sapiens | CHEMBL3705499 | cell-based format |
| CHEMBL3655062 |  |
IC50 | = | 5.0 | nM | 591.84 | CC(C)(C)c1ccc(C(C)(C)N2CCc3cc(S(=O)(=O)Nc4ccc(CCCC5CCCC5)cc4F)ccc3C2)cn1 | Homo sapiens | CHEMBL3705500 | assay format |
| CHEMBL5406388 |  |
IC50 | = | 5.0 | nM | 580.6 | Cc1ccc(-c2cc(-c3ccc(OCCCCCC(F)(F)F)cc3F)[nH]c(=O)c2C(=O)NS(=O)(=O)C2CC2)cc1 | Homo sapiens | CHEMBL5323325 | single protein format |
| CHEMBL5411014 |  |
IC50 | = | 5.0 | nM | 554.56 | Cc1ccc(-c2cc(-c3ccc(OCCCCCC(F)(F)F)cc3F)[nH]c(=O)c2C(=O)NS(C)(=O)=O)cc1 | Homo sapiens | CHEMBL5323325 | single protein format |
| CHEMBL3134101 |  |
IC50 | = | 7.0 | nM | 505.9 | CCC1(C)NC(=O)c2cc(S(=O)(=O)Nc3ccc(C(F)(F)F)cc3OC)cc(Cl)c2NC1=O | Homo sapiens | CHEMBL3135117 | single protein format |
| CHEMBL3655036 |  |
IC50 | = | 7.0 | nM | 595.78 | CCCCCCCCOc1ccc(NS(=O)(=O)c2ccc3c(c2)CN(C(=O)Nc2ccc(C(C)(C)C)cc2)C3)c(F)c1 | Homo sapiens | CHEMBL3705499 | cell-based format |
| CHEMBL5435045 |  |
IC50 | = | 8.0 | nM | 475.5 | CCc1ccc(-c2cc(-c3ccc(OCCCC(F)(F)F)cc3)[nH]c(=O)c2-c2nnn[nH]2)s1 | Homo sapiens | CHEMBL5323325 | single protein format |
| CHEMBL5401316 |  |
IC50 | = | 8.0 | nM | 489.89 | Cc1ccc(-c2cc(-c3ccc(OCCCC(F)(F)F)cc3Cl)[nH]c(=O)c2-c2nnn[nH]2)cc1 | Homo sapiens | CHEMBL5323325 | single protein format |
| CHEMBL3134098 |  |
IC50 | = | 9.0 | nM | 443.86 | CCC1(C)NC(=O)c2cc(S(=O)(=O)Nc3ccc(F)cc3F)cc(Cl)c2NC1=O | Homo sapiens | CHEMBL3135117 | single protein format |
| CHEMBL5413599 |  |
IC50 | = | 9.0 | nM | 487.46 | Cc1ccc(-c2cc(-c3ccc(OCCCCC(F)(F)F)cc3F)[nH]c(=O)c2-c2nnn[nH]2)cc1 | Homo sapiens | CHEMBL5323325 | single protein format |
| CHEMBL3134084 |  |
IC50 | = | 10.0 | nM | 439.44 | CCC1(C)NC(=O)c2cc(S(=O)(=O)Nc3ccc(F)cc3F)cc(OC)c2NC1=O | Homo sapiens | CHEMBL3135117 | single protein format |
| CHEMBL2376303 |  |
IC50 | = | 10.0 | nM | 409.41 | CC[C@]1(C)NC(=O)c2cc(S(=O)(=O)Nc3ccc(F)cc3F)ccc2NC1=O | Homo sapiens | CHEMBL3135117 | single protein format |
| CHEMBL3655069 |  |
IC50 | = | 10.0 | nM | 458.64 | CC(C)N1CCc2cc(S(=O)(=O)Nc3ccc(CCCC4CCCC4)cc3F)ccc2C1 | Homo sapiens | CHEMBL3705500 | assay format |