Q2NL67 | PARP6_HUMAN | Protein mono-ADP-ribosyltransferase PARP6 (PARP6)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00644 | PARP - Poly(ADP-ribose) polymerase catalytic domain | 456~526 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5402698 |  |
IC50 | = | 9.5 | nM | 549.36 | O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCn2c(nnc2-c2ccc(Br)o2)C1 | Homo sapiens | CHEMBL5366433 | single protein format |
| CHEMBL3740897 |  |
IC50 | = | 83.0 | nM | 500.46 | C[C@H]1Cn2c(nnc2C(C)(F)F)CN1C(=O)c1cccc(C(F)(F)c2n[nH]c(=O)c3ccccc23)c1 | Homo sapiens | CHEMBL3743853 | cell-based format |
| CHEMBL521686 |  |
IC50 | = | 120.0 | nM | 434.47 | O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCN(C(=O)C2CC2)CC1 | Homo sapiens | CHEMBL5373894 | cell-based format |
| CHEMBL3740104 |  |
IC50 | = | 640.0 | nM | 450.5 | N#Cc1cccnc1N1CCN(C(=O)c2cccc(Cc3n[nH]c(=O)c4ccccc34)c2)CC1 | Homo sapiens | CHEMBL3743853 | cell-based format |