Q2M2I8 | AAK1_HUMAN | AP2-associated protein kinase 1 (AAK1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 48~307 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4085072 |  |
IC50 | = | 0.07 | nM | 374.53 | CC(C)C[C@](C)(N)COc1ccc(-c2ccnc3ccccc23)cc1C1CC1 | Homo sapiens | CHEMBL4022632 | assay format |
| CHEMBL4544854 |  |
IC50 | = | 0.2 | nM | 374.44 | CC(C)C[C@](C)(N)COc1ccc(-c2ccnc3ccnn23)cc1C(F)F | Homo sapiens | CHEMBL4305771 | assay format |
| CHEMBL4065155 |  |
IC50 | = | 0.23 | nM | 385.46 | CC(C)C[C@](C)(N)COc1ncc(-c2ccnc3ccccc23)cc1C(F)F | Homo sapiens | CHEMBL4022632 | assay format |
| CHEMBL5178261 |  |
IC50 | = | 0.3 | nM | 425.45 | COC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(C(F)(F)F)c2)ccn1 | Homo sapiens | CHEMBL5161145 | single protein format |
| CHEMBL4534648 |  |
IC50 | = | 0.3 | nM | 352.44 | CC(=O)Nc1cc(-c2ccc(OC[C@@H](N)CC(C)C)c(C#N)c2)ccn1 | Homo sapiens | CHEMBL4305771 | assay format |
| CHEMBL4084103 |  |
IC50 | = | 0.32 | nM | 397.52 | COC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(C3CC3)c2)ccn1 | Homo sapiens | CHEMBL4022632 | assay format |
| CHEMBL5088205 |  |
IC50 | = | 0.4 | nM | 384.42 | CC(C)C[C@](C)(N)COc1ccc(-c2ccnc(C(F)F)c2)cc1C(F)F | Homo sapiens | CHEMBL5049597 | single protein format |
| CHEMBL5185616 |  |
IC50 | = | 0.4 | nM | 395.43 | CC(=O)Nc1cc(-c2ccc(OC[C@@H](N)CC(C)C)c(C(F)(F)F)c2)ccn1 | Homo sapiens | CHEMBL5161145 | single protein format |
| CHEMBL5188433 |  |
IC50 | = | 0.4 | nM | 392.89 | COC(=O)Nc1cc(-c2cnc(OC[C@@](C)(N)CC(C)C)c(Cl)c2)ccn1 | Homo sapiens | CHEMBL5161145 | single protein format |
| CHEMBL5204210 |  |
IC50 | = | 0.4 | nM | 408.45 | COC(=O)Nc1cc(-c2cc(C(F)F)c(OC[C@@](C)(N)CC(C)C)cn2)ccn1 | Homo sapiens | CHEMBL5161145 | single protein format |
| CHEMBL5092306 |  |
IC50 | = | 0.4 | nM | 348.44 | Cc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(C(F)F)c2)ccn1 | Homo sapiens | CHEMBL5049597 | single protein format |
| CHEMBL5178245 |  |
IC50 | = | 0.4 | nM | 426.44 | COC(=O)Nc1cc(-c2cc(C(F)(F)F)c(OC[C@@](C)(N)CC(C)C)cn2)ccn1 | Homo sapiens | CHEMBL5161145 | single protein format |
| CHEMBL5183016 |  |
IC50 | = | 0.4 | nM | 409.45 | CC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(C(F)(F)F)c2)ccn1 | Homo sapiens | CHEMBL5161145 | single protein format |
| CHEMBL4062388 |  |
IC50 | = | 0.42 | nM | 341.46 | CC(=O)Nc1cc(-c2ccc(OC[C@@H](N)CC(C)C)c(C)c2)ccn1 | Homo sapiens | CHEMBL4022632 | assay format |
| CHEMBL5205578 |  |
IC50 | = | 0.5 | nM | 392.89 | COC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(Cl)n2)ccn1 | Homo sapiens | CHEMBL5161145 | single protein format |
| CHEMBL5187778 |  |
IC50 | = | 0.5 | nM | 391.9 | COC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(Cl)c2)ccn1 | Homo sapiens | CHEMBL5161145 | single protein format |
| CHEMBL5202370 |  |
IC50 | = | 0.5 | nM | 407.46 | COC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(C(F)F)c2)ccn1 | Homo sapiens | CHEMBL5161145 | single protein format |
| CHEMBL5174967 |  |
IC50 | = | 0.5 | nM | 382.46 | COC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(C#N)c2)ccn1 | Homo sapiens | CHEMBL5161145 | single protein format |
| CHEMBL5179172 |  |
IC50 | = | 0.5 | nM | 411.42 | CC(=O)Nc1cc(-c2ccc(OC[C@@H](N)CC(C)C)c(OC(F)(F)F)c2)ccn1 | Homo sapiens | CHEMBL5161145 | single protein format |
| CHEMBL5186783 |  |
IC50 | = | 0.5 | nM | 361.87 | CC(=O)Nc1cc(-c2ccc(OC[C@@H](N)CC(C)C)c(Cl)c2)ccn1 | Homo sapiens | CHEMBL5161145 | single protein format |