Q16880 | CGT_HUMAN | 2-hydroxyacylsphingosine 1-beta-galactosyltransferase (UGT8)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00201 | UDPGT - UDP-glucoronosyl and UDP-glucosyl transferase | 30~503 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4785914 |  |
IC50 | = | 0.2 | nM | 528.48 | CNC(=O)c1csc2c(C(F)(F)F)cc(N3CCC(OC(=O)N[C@@H](C)COC(F)(F)F)CC3)nc12 | Homo sapiens | CHEMBL4731219 | cell-based format |
| CHEMBL4796521 |  |
IC50 | = | 0.4 | nM | 514.45 | CNC(=O)c1csc2c(C(F)(F)F)cc(N3CCC(OC(=O)NCCOC(F)(F)F)CC3)nc12 | Homo sapiens | CHEMBL4731219 | cell-based format |
| CHEMBL4750073 |  |
IC50 | = | 0.9 | nM | 470.52 | CNC(=O)c1csc2c(C(F)(F)F)cc(N3CCC(OC(=O)N[C@@H](C)C4CC4)CC3)nc12 | Homo sapiens | CHEMBL4731219 | cell-based format |
| CHEMBL4787939 |  |
IC50 | = | 0.9 | nM | 458.51 | CC[C@H](C)NC(=O)OC1CCN(c2cc(C(F)(F)F)c3scc(C(=O)NC)c3n2)CC1 | Homo sapiens | CHEMBL4731219 | cell-based format |
| CHEMBL4776963 |  |
IC50 | = | 1.0 | nM | 456.49 | CNC(=O)c1csc2c(C(F)(F)F)cc(N3CCC(OC(=O)NCC4CC4)CC3)nc12 | Homo sapiens | CHEMBL4731219 | cell-based format |
| CHEMBL4750432 |  |
IC50 | = | 1.7 | nM | 526.46 | CNC(=O)c1csc2c(C(F)(F)F)cc(N3CCC(OC(=O)N4CC(OC(F)(F)F)C4)CC3)nc12 | Homo sapiens | CHEMBL4731219 | cell-based format |
| CHEMBL4765010 |  |
IC50 | = | 2.0 | nM | 444.48 | CNC(=O)c1csc2c(C(F)(F)F)cc(N3CCC(OC(=O)NC(C)C)CC3)nc12 | Homo sapiens | CHEMBL4731219 | cell-based format |
| CHEMBL4755797 |  |
IC50 | = | 18.0 | nM | 456.49 | CNC(=O)c1csc2c(C(F)(F)F)cc(N3CCC(NC(=O)OCC4CC4)CC3)nc12 | Homo sapiens | CHEMBL4731219 | cell-based format |
| CHEMBL4757982 |  |
IC50 | = | 48.0 | nM | 428.44 | CNC(=O)c1csc2c(C(F)(F)F)cc(N3CC(NC(=O)OCC4CC4)C3)nc12 | Homo sapiens | CHEMBL4731219 | cell-based format |
| CHEMBL4760937 |  |
IC50 | = | 67.0 | nM | 443.5 | CNC(=O)c1csc2c(C(F)(F)F)cc(N3CCN(CC(=O)NC(C)C)CC3)nc12 | Homo sapiens | CHEMBL4731219 | cell-based format |
| CHEMBL4795937 |  |
IC50 | = | 97.0 | nM | 442.51 | CCC(=O)c1csc2c(C(F)(F)F)cc(N3CCN(CC(=O)NC(C)C)CC3)nc12 | Homo sapiens | CHEMBL4731219 | cell-based format |
| CHEMBL4799472 |  |
IC50 | = | 170.0 | nM | 455.51 | CNC(=O)c1csc2c(C(F)(F)F)cc(N3CCN(C(C)C(=O)NC4CC4)CC3)nc12 | Homo sapiens | CHEMBL4731219 | cell-based format |
| CHEMBL4797076 |  |
IC50 | = | 190.0 | nM | 474.55 | CNC(=O)c1csc2c(C(F)(F)F)cc(N3CCN(CC(O)COC(C)(C)C)CC3)nc12 | Homo sapiens | CHEMBL4731219 | cell-based format |
| CHEMBL4764180 |  |
IC50 | = | 200.0 | nM | 428.44 | CNC(=O)c1csc2c(C(F)(F)F)cc(N3CC(OC(=O)NCC4CC4)C3)nc12 | Homo sapiens | CHEMBL4731219 | cell-based format |
| CHEMBL4751927 |  |
IC50 | = | 330.0 | nM | 430.5 | CNC(=O)c1csc2c(C(F)(F)F)cc(N3CCN(CCOC(C)C)CC3)nc12 | Homo sapiens | CHEMBL4731219 | cell-based format |
| CHEMBL4799203 |  |
IC50 | = | 510.0 | nM | 499.56 | CNC(=O)c1csc2c(C(F)(F)F)cc(N3CCC(OC(=O)NCCN4CCCC4)CC3)nc12 | Homo sapiens | CHEMBL4731219 | cell-based format |
| CHEMBL4762406 |  |
IC50 | = | 610.0 | nM | 442.46 | CNC(=O)c1csc2c(C(F)(F)F)cc(N3CCC(OC(=O)NCC4CC4)C3)nc12 | Homo sapiens | CHEMBL4731219 | cell-based format |
| CHEMBL4791074 |  |
IC50 | = | 610.0 | nM | 442.51 | CNC(=O)c1csc2c(C(F)(F)F)cc(N3CCN(CC(=O)C(C)(C)C)CC3)nc12 | Homo sapiens | CHEMBL4731219 | cell-based format |
| CHEMBL4747085 |  |
IC50 | = | 640.0 | nM | 469.53 | CC(C)NC(=O)CN1CCN(c2cc(C(F)(F)F)c3scc(C(=O)N4CCC4)c3n2)CC1 | Homo sapiens | CHEMBL4731219 | cell-based format |
| CHEMBL4745037 |  |
IC50 | = | 660.0 | nM | 444.48 | CNC(=O)c1csc2c(C(F)(F)F)cc(N3CCN(C(=O)COC(C)C)CC3)nc12 | Homo sapiens | CHEMBL4731219 | cell-based format |