Q16877 | F264_HUMAN | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00300 | His_Phos_1 - Histidine phosphatase superfamily (branch 1) | 252~435 | |
| PF01591 | 6PF2K - 6-phosphofructo-2-kinase | 35~249 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3731843 |  |
IC50 | = | 60.0 | nM | 389.5 | Cc1c(S(=O)(=O)Nc2cccc(C(=O)O)c2)sc2ccc(C(C)C)cc12 | Homo sapiens | CHEMBL3734144 | assay format |
| CHEMBL3731045 |  |
IC50 | = | 100.0 | nM | 396.51 | Cc1c(S(=O)(=O)Nc2ncc(C(=O)O)s2)sc2ccc(C(C)C)cc12 | Homo sapiens | CHEMBL3734144 | assay format |
| CHEMBL3728731 |  |
IC50 | = | 130.0 | nM | 381.86 | Cc1c(S(=O)(=O)Nc2cccc(C(=O)O)c2)sc2ccc(Cl)cc12 | Homo sapiens | CHEMBL3734144 | assay format |
| CHEMBL3731894 |  |
IC50 | = | 140.0 | nM | 371.45 | Cc1ccc2sc(S(=O)(=O)Nc3cccc(-c4nnn[nH]4)c3)cc2c1 | Homo sapiens | CHEMBL3734144 | assay format |
| CHEMBL3731503 |  |
IC50 | = | 170.0 | nM | 389.44 | Cc1c(S(=O)(=O)Nc2cccc(-c3nnn[nH]3)c2)sc2ccc(F)cc12 | Homo sapiens | CHEMBL3734144 | assay format |
| CHEMBL3729923 |  |
IC50 | = | 180.0 | nM | 397.86 | Cc1c(S(=O)(=O)Nc2cccc(C(=O)O)c2O)sc2ccc(Cl)cc12 | Homo sapiens | CHEMBL3734144 | assay format |
| CHEMBL3727732 |  |
IC50 | = | 200.0 | nM | 381.86 | Cc1c(S(=O)(=O)Nc2cccc(C(=O)O)c2)sc2c(Cl)cccc12 | Homo sapiens | CHEMBL3734144 | assay format |
| CHEMBL3729559 |  |
IC50 | = | 390.0 | nM | 377.43 | O=S(=O)(Nc1cccc(-c2nnn[nH]2)c1)c1cccc(-c2ccccc2)c1 | Homo sapiens | CHEMBL3734144 | assay format |
| CHEMBL3731358 |  |
IC50 | = | 420.0 | nM | 431.53 | CSc1nccc(-c2ccc(S(=O)(=O)Nc3cccc(-c4nnn[nH]4)c3)s2)n1 | Homo sapiens | CHEMBL3734144 | assay format |
| CHEMBL3727631 |  |
IC50 | = | 420.0 | nM | 377.44 | COc1cccc2c(C)c(S(=O)(=O)Nc3cccc(C(=O)O)c3)sc12 | Homo sapiens | CHEMBL3734144 | assay format |
| CHEMBL3732792 |  |
IC50 | = | 480.0 | nM | 397.49 | Cc1ccc(-c2ccc(S(=O)(=O)Nc3cccc(-c4nnn[nH]4)c3)s2)cc1 | Homo sapiens | CHEMBL3734144 | assay format |
| CHEMBL3728448 |  |
IC50 | = | 510.0 | nM | 438.22 | O=S(=O)(Nc1cccc(-c2nnn[nH]2)c1)c1c(Cl)cc(C(F)(F)F)cc1Cl | Homo sapiens | CHEMBL3734144 | assay format |
| CHEMBL3729843 |  |
IC50 | = | 600.0 | nM | 419.44 | O=S(=O)(Nc1cccc(-c2nnn[nH]2)c1)c1ccc(-c2ccc(F)cc2F)s1 | Homo sapiens | CHEMBL3734144 | assay format |
| CHEMBL3728006 |  |
IC50 | = | 660.0 | nM | 413.48 | COc1ccccc1-c1ccc(S(=O)(=O)Nc2cccc(-c3nnn[nH]3)c2)s1 | Homo sapiens | CHEMBL3734144 | assay format |
| CHEMBL3730654 |  |
IC50 | = | 660.0 | nM | 435.89 | O=S(=O)(Nc1cccc(-c2nnn[nH]2)c1)c1ccc(-c2ccc(F)c(Cl)c2)s1 | Homo sapiens | CHEMBL3734144 | assay format |
| CHEMBL3728043 |  |
IC50 | = | 750.0 | nM | 417.9 | O=S(=O)(Nc1cccc(-c2nnn[nH]2)c1)c1ccc(-c2ccccc2Cl)s1 | Homo sapiens | CHEMBL3734144 | assay format |