Q16875 | F263_HUMAN | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00300 | His_Phos_1 - Histidine phosphatase superfamily (branch 1) | 249~432 | |
| PF01591 | 6PF2K - 6-phosphofructo-2-kinase | 26~246 |
3D structures mapped by conservation among orthologs
[ Domain: "P-loop containing nucleoside triphosphate hydrolases" // 6PF2K ]
[ Domain: "Phosphoglycerate mutase-like" // His_Phos_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3730063 |  |
IC50 | = | 0.0 | nM | 423.52 | Cc1nc(N[C@@H](C)c2cccc(-c3cnn(C)c3)c2)cc(-c2ccc3occ(C)c3c2)n1 | Homo sapiens | CHEMBL3734213 | single protein format |
| CHEMBL3732068 |  |
IC50 | = | 0.0 | nM | 425.36 | Cc1nc(N[C@@H](C)c2cccc(Br)c2)cc(-c2ccc3ncsc3c2)n1 | Homo sapiens | CHEMBL3734213 | single protein format |
| CHEMBL3732478 |  |
IC50 | = | 0.0 | nM | 457.99 | Cc1nc(N[C@@H](C)c2cccc(-c3ccc(Cl)nc3)c2)cc(-c2ccc3ncsc3c2)n1 | Homo sapiens | CHEMBL3734214 | single protein format |
| CHEMBL3727653 |  |
IC50 | = | 0.0 | nM | 463.59 | CCNc1ccc(-c2cccc([C@H](C)Nc3cc(-c4ccc5occ(C)c5c4)nc(C)n3)c2)cn1 | Homo sapiens | CHEMBL3734214 | single protein format |
| CHEMBL3728820 |  |
IC50 | = | 0.0 | nM | 312.44 | CCCC(C)Nc1cc(-c2ccc3ncsc3c2)nc(C)n1 | Homo sapiens | CHEMBL3734213 | single protein format |
| CHEMBL3731532 |  |
IC50 | = | 0.0 | nM | 532.69 | CCN1CCN(c2ccc(-c3cccc([C@H](C)Nc4cc(-c5ccc6occ(C)c6c5)nc(C)n4)c3)cn2)CC1 | Homo sapiens | CHEMBL3734214 | single protein format |
| CHEMBL3729999 |  |
IC50 | = | 0.0 | nM | 535.72 | CCN1CCN(c2ccc(-c3cccc([C@H](C)Nc4cc(-c5ccc6ncsc6c5)nc(C)n4)c3)cn2)CC1 | Homo sapiens | CHEMBL3734214 | single protein format |
| CHEMBL3727507 |  |
IC50 | = | 0.0 | nM | 437.51 | Cc1nc(NC(C)c2cncc(-c3cnc(N)nc3)c2)cc(-c2ccc3occ(C)c3c2)n1 | Homo sapiens | CHEMBL3734214 | single protein format |
| CHEMBL3727790 |  |
IC50 | = | 0.0 | nM | 438.36 | Cc1nc(NC(C)c2cccc(-c3cnn(C)c3)c2)cc(-c2ccc(Cl)c(Cl)c2)n1 | Homo sapiens | CHEMBL3734213 | single protein format |
| CHEMBL3733107 |  |
IC50 | = | 0.0 | nM | 397.53 | Cc1ccc(C)c(-c2cc(NC(C)c3cccc(-c4cnn(C)c4)c3)nc(C)n2)c1 | Homo sapiens | CHEMBL3734213 | single protein format |
| CHEMBL3728085 |  |
IC50 | = | 0.0 | nM | 433.58 | Cc1nc(NC(C)c2cccc(OCCN(C)C)c2)cc(-c2ccc3ncsc3c2)n1 | Homo sapiens | CHEMBL3734213 | single protein format |
| CHEMBL3732242 |  |
IC50 | = | 0.0 | nM | 444.54 | Cc1nc(N[C@H](C)c2cccc(OCC(=O)N(C)C)c2)cc(-c2ccc3occ(C)c3c2)n1 | Homo sapiens | CHEMBL3734213 | single protein format |
| CHEMBL3728811 |  |
IC50 | = | 0.0 | nM | 430.55 | Cc1nc(NC(C)c2cccc(OCCN(C)C)c2)cc(-c2ccc3occ(C)c3c2)n1 | Homo sapiens | CHEMBL3734213 | single protein format |
| CHEMBL3731409 |  |
IC50 | = | 0.0 | nM | 444.54 | Cc1nc(N[C@@H](C)c2cccc(OCC(=O)N(C)C)c2)cc(-c2ccc3occ(C)c3c2)n1 | Homo sapiens | CHEMBL3734213 | single protein format |
| CHEMBL3728409 |  |
IC50 | = | 0.0 | nM | 454.51 | Cc1nc(N[C@@H](C)c2cccc(-c3cnc(N)nc3)c2)cc(-c2cc(F)c3occ(C)c3c2)n1 | Homo sapiens | CHEMBL3734214 | single protein format |
| CHEMBL3728460 |  |
IC50 | = | 0.0 | nM | 426.55 | Cc1nc(N[C@@H](C)c2cccc(-c3cnn(C)c3)c2)cc(-c2ccc3ncsc3c2)n1 | Homo sapiens | CHEMBL3734213 | single protein format |
| CHEMBL3728539 |  |
IC50 | = | 0.0 | nM | 366.88 | Cc1nc(NCc2ccccc2Cl)cc(-c2ccc3ncsc3c2)n1 | Homo sapiens | CHEMBL3734213 | single protein format |
| CHEMBL3729777 |  |
IC50 | = | 0.0 | nM | 366.85 | Cc1nc(N[C@@H]2CCOc3ccccc32)cc(-c2ccc(Cl)c(N)c2)n1 | Homo sapiens | CHEMBL3734213 | single protein format |
| CHEMBL3729673 |  |
IC50 | = | 0.0 | nM | 367.46 | Cc1nc(N[C@@H]2CCCc3ccccc32)cc(-c2ccc3nccnc3c2)n1 | Homo sapiens | CHEMBL3734213 | single protein format |
| CHEMBL3730398 |  |
IC50 | = | 0.0 | nM | 508.65 | Cc1nc(N[C@@H](C)c2cccc(-c3ccc(N4CCOCC4)nc3)c2)cc(-c2ccc3ncsc3c2)n1 | Homo sapiens | CHEMBL3734214 | single protein format |