Q16873 | LTC4S_HUMAN | Leukotriene C4 synthase (LTC4S)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01124 | MAPEG - MAPEG family | 9~123 |
3D structures mapped by conservation among orthologs
[ Domain: "MAPEG domain-like" // MAPEG ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3903201 |  |
IC50 | = | 0.248 | nM | 473.4 | COc1nc(N(CC(C)(C)F)c2cc(C(F)(F)F)ccc2F)cnc1C(=O)[C@H]1C[C@@H]1C(=O)O | Homo sapiens | CHEMBL3888329 | single protein format |
| CHEMBL4549822 |  |
IC50 | = | 0.28 | nM | 439.85 | COc1nc(N(CC(C)C)c2cc(Cl)c(F)cc2F)cnc1C(=O)[C@H]1C[C@@H]1C(=O)O | Homo sapiens | CHEMBL4378183 | assay format |
| CHEMBL3961833 |  |
IC50 | = | 0.289 | nM | 457.84 | COc1nc(N(CC(C)(C)F)c2cc(Cl)c(F)cc2F)cnc1C(=O)[C@H]1C[C@@H]1C(=O)O | Homo sapiens | CHEMBL3888329 | single protein format |
| CHEMBL4567083 |  |
IC50 | = | 0.36 | nM | 455.41 | COc1nc(N(CC(C)C)c2cc(C(F)(F)F)ccc2F)cnc1C(=O)[C@H]1C[C@@H]1C(=O)O | Homo sapiens | CHEMBL4378183 | assay format |
| CHEMBL4464773 |  |
IC50 | = | 0.381 | nM | 436.48 | COc1cc(N(CC(C)C)c2ccc(F)c3ccccc23)cnc1C(=O)[C@H]1C[C@@H]1C(=O)O | Homo sapiens | CHEMBL4378183 | assay format |
| CHEMBL3914270 |  |
IC50 | = | 0.483 | nM | 425.82 | CCCN(c1cnc(C(=O)[C@H]2C[C@@H]2C(=O)O)c(OC)n1)c1cc(Cl)c(F)cc1F | Homo sapiens | CHEMBL3888329 | single protein format |
| CHEMBL4562583 |  |
IC50 | = | 0.6 | nM | 456.85 | COc1cc(N(CC(C)(C)F)c2cc(Cl)c(F)cc2F)cnc1C(=O)[C@H]1C[C@@H]1C(=O)O | Homo sapiens | CHEMBL4378183 | assay format |
| CHEMBL4563433 |  |
IC50 | = | 0.626 | nM | 422.46 | CCCN(c1cnc(C(=O)[C@H]2C[C@@H]2C(=O)O)c(OC)c1)c1ccc(F)c2ccccc12 | Homo sapiens | CHEMBL4378183 | assay format |
| CHEMBL4584584 |  |
IC50 | = | 0.63 | nM | 472.41 | COc1cc(N(CC(C)(C)F)c2cc(C(F)(F)F)ccc2F)cnc1C(=O)[C@H]1C[C@@H]1C(=O)O | Homo sapiens | CHEMBL4378183 | assay format |
| CHEMBL3971210 |  |
IC50 | = | 0.658 | nM | 454.42 | COc1cc(N(CC(C)C)c2cc(C(F)(F)F)ccc2F)cnc1C(=O)[C@H]1C[C@@H]1C(=O)O | Homo sapiens | CHEMBL3888329 | single protein format |
| CHEMBL4574439 |  |
IC50 | = | 0.7 | nM | 438.86 | COc1cc(N(CC(C)C)c2cc(Cl)c(F)cc2F)cnc1C(=O)[C@H]1C[C@@H]1C(=O)O | Homo sapiens | CHEMBL4378183 | assay format |
| CHEMBL4441362 |  |
IC50 | = | 0.758 | nM | 434.47 | COc1cc(N(CC2CC2)c2ccc(F)c3ccccc23)cnc1C(=O)[C@H]1C[C@@H]1C(=O)O | Homo sapiens | CHEMBL4378183 | assay format |
| CHEMBL4476024 |  |
IC50 | = | 1.05 | nM | 408.43 | CCN(c1cnc(C(=O)[C@H]2C[C@@H]2C(=O)O)c(OC)c1)c1ccc(F)c2ccccc12 | Homo sapiens | CHEMBL4378183 | assay format |
| CHEMBL4454609 |  |
IC50 | = | 1.41 | nM | 450.92 | COc1cc(N(CC2CC2)c2ccc(Cl)c3ccccc23)cnc1C(=O)[C@H]1C[C@@H]1C(=O)O | Homo sapiens | CHEMBL4378183 | assay format |
| CHEMBL4545014 |  |
IC50 | = | 1.97 | nM | 436.84 | COc1cc(N(CC2CC2)c2cc(Cl)c(F)cc2F)cnc1C(=O)[C@H]1C[C@@H]1C(=O)O | Homo sapiens | CHEMBL4378183 | assay format |
| CHEMBL5417047 |  |
IC50 | = | 2.0 | nM | 399.54 | CCOC(=O)Cc1csc(NC(=S)NC(C)c2cccc3ccccc23)n1 | Homo sapiens | CHEMBL5348488 | single protein format |
| CHEMBL4545950 |  |
IC50 | = | 2.08 | nM | 452.4 | COc1cc(N(CC2CC2)c2cc(C(F)(F)F)ccc2F)cnc1C(=O)[C@H]1C[C@@H]1C(=O)O | Homo sapiens | CHEMBL4378183 | assay format |
| CHEMBL4525972 |  |
IC50 | = | 2.4 | nM | 417.47 | COc1nc(C(=O)[C@H]2C[C@@H]2C(=O)O)ncc1N(CC1CC1)c1cccc2ccccc12 | Homo sapiens | CHEMBL4378183 | assay format |
| CHEMBL4467942 |  |
IC50 | = | 3.71 | nM | 418.85 | COc1cc(N(CC2CC2)c2cc(Cl)ccc2F)cnc1C(=O)[C@H]1C[C@@H]1C(=O)O | Homo sapiens | CHEMBL4378183 | assay format |
| CHEMBL4574370 |  |
IC50 | = | 4.74 | nM | 436.43 | COc1cc(N(CC(C)C)c2cccc(C(F)(F)F)c2)cnc1C(=O)[C@H]1C[C@@H]1C(=O)O | Homo sapiens | CHEMBL4378183 | assay format |