Q16853 | AOC3_HUMAN | Membrane primary amine oxidase (AOC3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01179 | Cu_amine_oxid - Copper amine oxidase, enzyme domain | 316~716 | |
| PF02727 | Cu_amine_oxidN2 - Copper amine oxidase, N2 domain | 66~152 | |
| PF02728 | Cu_amine_oxidN3 - Copper amine oxidase, N3 domain | 169~269 |
3D structures mapped by conservation among orthologs
[ Domain: "supersandwich" // Cu_amine_oxid ]
[ Domain: "Amine oxidase N-terminal region" // Cu_amine_oxidN2 ]
[ Domain: "Amine oxidase N-terminal region" // Cu_amine_oxidN3 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3897599 |  |
IC50 | = | 5.0 | nM | 316.8 | CC(C)(C)NC(=O)c1ccc(OC/C(=C/F)CN)cc1.Cl | Homo sapiens | CHEMBL3870772 | single protein format |
| CHEMBL3643999 |  |
IC50 | = | 6.9 | nM | 501.59 | Cc1cc(/C=C/C(=O)O)cnc1N1CCN(c2ncc(-c3cccc(CN(C)C(=O)CN)c3)cn2)CC1 | Homo sapiens | CHEMBL3705460 | assay format |
| CHEMBL3644015 |  |
IC50 | = | 7.0 | nM | 414.51 | CN(Cc1cccc(-c2cnc(N3CC=C(c4cccnc4)CC3)nc2)c1)C(=O)CN | Homo sapiens | CHEMBL3705460 | assay format |
| CHEMBL4077021 |  |
IC50 | = | 9.2 | nM | 410.84 | Cl.N=C(N)NC(=O)OCc1cccc(-c2cnc(N3CCOCC3)nc2)c1F | Homo sapiens | CHEMBL4047930 | cell-based format |
| CHEMBL3644003 |  |
IC50 | = | 9.4 | nM | 503.61 | Cc1cc(CCC(=O)O)cnc1N1CCN(c2ncc(-c3cccc(CN(C)C(=O)CN)c3)cn2)CC1 | Homo sapiens | CHEMBL3705460 | assay format |
| CHEMBL2029546 |  |
IC50 | = | 10.0 | nM | 306.38 | NC/C=C(/F)COc1ccc(C(=O)NC2CCCCC2)cc1 | Homo sapiens | CHEMBL2034300 | single protein format |
| CHEMBL3644011 |  |
IC50 | = | 11.0 | nM | 374.45 | CN(Cc1cccc(-c2cnc(N3Cc4cccnc4C3)nc2)c1)C(=O)CN | Homo sapiens | CHEMBL3705460 | assay format |
| CHEMBL4087881 |  |
IC50 | = | 13.0 | nM | 463.8 | Cl.Cl.Cl.N=C(N)NC(=O)OCc1cccc(N2CCN(c3ccncc3)CC2)c1 | Homo sapiens | CHEMBL4047930 | cell-based format |
| CHEMBL3644016 |  |
IC50 | = | 17.0 | nM | 389.48 | CN(Cc1cccc(-c2cnc(N3CCS(=O)(=O)CC3)nc2)c1)C(=O)CN | Homo sapiens | CHEMBL3705460 | assay format |
| CHEMBL4068948 |  |
IC50 | = | 17.0 | nM | 522.49 | N=C(N)NC(=O)OCc1cccc(N2CCN(c3cccnc3)CC2)c1F.O=C(O)[C@H](O)[C@@H](O)C(=O)O | Homo sapiens | CHEMBL4047930 | cell-based format |
| CHEMBL3644010 |  |
IC50 | = | 18.0 | nM | 431.54 | Cc1ncccc1N1CCN(c2ncc(-c3cccc(CN(C)C(=O)CN)c3)cn2)CC1 | Homo sapiens | CHEMBL3705460 | assay format |
| CHEMBL3644000 |  |
IC50 | = | 18.0 | nM | 495.97 | CN(Cc1cccc(-c2cnc(N3CCN(c4ncc(C(=O)O)cc4Cl)CC3)nc2)c1)C(=O)CN | Homo sapiens | CHEMBL3705460 | assay format |
| CHEMBL2392121 |  |
IC50 | = | 19.0 | nM | 377.9 | CC(=O)Nc1nc(CCc2ccc(Cc3c[nH]c(N)n3)cc2)cs1.Cl | Homo sapiens | CHEMBL2393976 | cell-based format |
| CHEMBL3110302 |  |
IC50 | = | 20.0 | nM | 499.41 | CN1CCN(c2ccc(Nc3cc(=O)n(-c4ccc(Cl)cc4)nc3-c3nc[nH]n3)cc2)CC1.Cl | Homo sapiens | CHEMBL3112059 | cell-based format |
| CHEMBL2029545 |  |
IC50 | = | 20.0 | nM | 292.35 | NC/C=C(/F)COc1ccc(C(=O)NC2CCCC2)cc1 | Homo sapiens | CHEMBL2034300 | single protein format |
| CHEMBL1489913 |  |
IC50 | = | 20.0 | nM | 112.09 | O=c1ccc(=O)[nH][nH]1 | Homo sapiens | CHEMBL3293751 | single protein format |
| CHEMBL2029534 |  |
IC50 | = | 20.0 | nM | 227.3 | CSc1ccc(OC/C(F)=C\CN)cc1 | Homo sapiens | CHEMBL2034300 | single protein format |
| CHEMBL2376161 |  |
IC50 | = | 20.0 | nM | 471.61 | CC(=O)Nc1nc(CCc2ccc(NC(=N)N)cc2)c(Cc2ccc(S(C)(=O)=O)cc2)s1 | Homo sapiens | CHEMBL2378525 | cell-based format |
| CHEMBL3644012 |  |
IC50 | = | 20.0 | nM | 408.53 | Cc1nc2c(s1)CN(c1ncc(-c3cccc(CN(C)C(=O)CN)c3)cn1)CC2 | Homo sapiens | CHEMBL3705460 | assay format |
| CHEMBL537623 |  |
IC50 | = | 20.0 | nM | 281.23 | CCNc1cncc(N(C)CC)c1CN.Cl.Cl | Homo sapiens | CHEMBL832086 | single protein format |