Q16832 | DDR2_HUMAN | Discoidin domain-containing receptor 2 (DDR2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00754 | F5_F8_type_C - F5/8 type C domain | 46~182 | |
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 563~846 | |
| PF21114 | DDR1-2_DS-like - Discoidin domain-containing receptor 1/2, DS-like domain | 190~366 |
3D structures mapped by conservation among orthologs
[ Domain: "Galactose-binding domain-like" // F5_F8_type_C ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4062877 |  |
IC50 | = | 0.8 | nM | 454.51 | Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3cc(F)ccc3O)cc12 | Homo sapiens | CHEMBL4018633 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 1.19 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328385 | single protein format |
| CHEMBL4443643 |  |
IC50 | = | 1.2 | nM | 369.47 | Cc1ccc(C(=O)Nc2cccc(C(C)C)c2)cc1-c1ccc2cn[nH]c2c1 | Homo sapiens | CHEMBL4412316 | single protein format |
| CHEMBL4448547 |  |
IC50 | = | 1.5 | nM | 395.38 | Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1ccc2cn[nH]c2c1 | Homo sapiens | CHEMBL4412316 | single protein format |
| CHEMBL2403875 |  |
IC50 | = | 2.0 | nM | 492.59 | CC(C)(C)c1cc(NC(=O)Nc2cccc(Nc3ncnc4ccccc34)c2)n(-c2cccc(N)c2)n1 | Homo sapiens | CHEMBL3265735 | single protein format |
| CHEMBL1688860 |  |
IC50 | = | 2.6 | nM | 538.57 | CN(C)Cc1cc(C(=O)N[C@@H]2CCc3ccc(Oc4ccnc5c4CCC(=O)N5)cc3C2)cc(C(F)(F)F)c1 | Homo sapiens | CHEMBL1693589 | single protein format |
| CHEMBL4559322 |  |
IC50 | = | 2.6 | nM | 574.61 | Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1ccc2c(-c3cnn(CCN4CCOCC4)c3)n[nH]c2c1 | Homo sapiens | CHEMBL4412316 | single protein format |
| CHEMBL4466555 |  |
IC50 | = | 2.6 | nM | 514.9 | Cc1ccc(C(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1NC(=O)C1(c2ncnc3[nH]cnc23)CC1 | Homo sapiens | CHEMBL4331421 | single protein format |
| CHEMBL4535267 |  |
IC50 | = | 2.6 | nM | 489.5 | CCn1cc(-c2n[nH]c3cc(-c4cc(C(=O)Nc5cccc(C(F)(F)F)c5)ccc4C)ccc23)cn1 | Homo sapiens | CHEMBL4412316 | single protein format |
| CHEMBL4460782 |  |
IC50 | = | 2.7 | nM | 546.55 | Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1ccc2c(-c3cnn(CC(=O)N(C)C)c3)n[nH]c2c1 | Homo sapiens | CHEMBL4412316 | single protein format |
| CHEMBL4525313 |  |
IC50 | = | 2.7 | nM | 394.48 | Cc1ccc(C(=O)Nc2cccc(C(C)(C)C#N)c2)cc1-c1ccc2cn[nH]c2c1 | Homo sapiens | CHEMBL4412316 | single protein format |
| CHEMBL4572126 |  |
IC50 | = | 2.9 | nM | 505.5 | Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1ccc2c(-c3cnn(CCO)c3)n[nH]c2c1 | Homo sapiens | CHEMBL4412316 | single protein format |
| CHEMBL3907057 |  |
IC50 | = | 3.0 | nM | 558.54 | Cc1cc(C)c(-n2ccn3nc(-c4cccnc4)cc23)cc1NC(=O)c1cc(C#N)cc(S(F)(F)(F)(F)F)c1 | Homo sapiens | CHEMBL5210176 | assay format |
| CHEMBL2403816 |  |
IC50 | = | 3.0 | nM | 492.59 | CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4ccccc34)cc2)n(-c2cccc(N)c2)n1 | Homo sapiens | CHEMBL3265735 | single protein format |
| CHEMBL4161036 |  |
IC50 | = | 3.1 | nM | 532.57 | Cc1ccc(C(=O)Nc2cc(CN3CCN(C)CC3)cc(C(F)(F)F)c2)cc1C#Cc1cnc2cnccn12 | Homo sapiens | CHEMBL4151609 | single protein format |
| CHEMBL4449358 |  |
IC50 | = | 3.2 | nM | 503.53 | CCCn1cc(-c2n[nH]c3cc(-c4cc(C(=O)Nc5cccc(C(F)(F)F)c5)ccc4C)ccc23)cn1 | Homo sapiens | CHEMBL4412316 | single protein format |
| CHEMBL4534119 |  |
IC50 | = | 3.2 | nM | 501.51 | Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1ccc2c(-c3cnn(C4CC4)c3)n[nH]c2c1 | Homo sapiens | CHEMBL4412316 | single protein format |
| CHEMBL3608786 |  |
IC50 | = | 3.3 | nM | 417.44 | Cc1ccc(CNC(=O)Nc2cccc(F)c2)cc1NC(=O)c1cnc2ccccn12 | Homo sapiens | CHEMBL3610834 | single protein format |
| CHEMBL4538678 |  |
IC50 | = | 3.4 | nM | 537.59 | Cc1ccc(C(=O)Nc2cc(CN3CCN(CCO)CC3)cc(C(F)(F)F)c2)cc1-c1ccc2cn[nH]c2c1 | Homo sapiens | CHEMBL4412316 | single protein format |
| CHEMBL4458216 |  |
IC50 | = | 3.7 | nM | 519.53 | Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1ccc2c(-c3cnn(CC(C)O)c3)n[nH]c2c1 | Homo sapiens | CHEMBL4412316 | single protein format |