Q16827 | PTPRO_HUMAN | Receptor-type tyrosine-protein phosphatase O (PTPRO)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00041 | fn3 - Fibronectin type III domain | 435~526 | |
| PF00041 | fn3 - Fibronectin type III domain | 725~805 | |
| PF00102 | Y_phosphatase - Protein-tyrosine phosphatase | 962~1192 |
3D structures mapped by conservation among orthologs
[ Domain: "(Phosphotyrosine protein) phosphatases II" // Y_phosphatase ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4063743 |  |
IC50 | < | 1000.0 | nM | 459.04 | O=C1NN(c2ccc(I)cc2)C(=O)/C1=C/c1ccc(Br)o1 | Homo sapiens | CHEMBL3991951 | single protein format |
| CHEMBL4091549 |  |
IC50 | < | 1000.0 | nM | 535.3 | N#Cc1ccc(C(=O)Nc2ccc(C(=O)N/N=C3\C(=O)Nc4ccc(I)cc43)cc2)cc1 | Homo sapiens | CHEMBL3991951 | single protein format |
| CHEMBL4067333 |  |
IC50 | < | 1000.0 | nM | 577.64 | CCCCCCCCC#Cc1ccc(CN(C(=O)/C=C/c2cccc(C(F)(F)F)c2)c2ccc(O)c(C(=O)O)c2)cc1 | Homo sapiens | CHEMBL3991951 | single protein format |
| CHEMBL4063482 |  |
IC50 | < | 1000.0 | nM | 483.65 | CCCCCCN(Cc1ccc(C#Cc2ccc(CCCC)cc2)cc1)c1ccc(O)c(C(=O)O)c1 | Homo sapiens | CHEMBL3991951 | single protein format |
| CHEMBL4083629 |  |
IC50 | < | 1000.0 | nM | 521.58 | CCCCCCc1ccc(C#Cc2ccc(CN(Cc3ccc(C(F)(F)F)cc3)C(=O)C(=O)O)cc2)cc1 | Homo sapiens | CHEMBL3991951 | single protein format |
| CHEMBL4103320 |  |
IC50 | < | 1000.0 | nM | 511.66 | CCCCCCN(Cc1ccc(C#Cc2ccc(CCCC)cc2)cc1)C(=O)c1ccc(O)c(C(=O)O)c1 | Homo sapiens | CHEMBL3991951 | single protein format |
| CHEMBL4063482 | |
Ki | = | 123.0 | nM | 483.65 | CCCCCCN(Cc1ccc(C#Cc2ccc(CCCC)cc2)cc1)c1ccc(O)c(C(=O)O)c1 | Homo sapiens | CHEMBL5233990 | single protein format |