Q16820 | MEP1B_HUMAN | Meprin A subunit beta (MEP1B)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00629 | MAM - MAM domain, meprin/A5/mu | 265~428 | |
| PF01400 | Astacin - Astacin (Peptidase family M12A) | 70~256 | |
| PF22486 | MATH_2 - MATH domain | 429~585 |
3D structures mapped by conservation among orthologs
[ Domain: "Concanavalin A-like lectins/glucanases" // MAM ]
[ Domain: "TRAF domain-like" // MATH ]
[ Domain: "Metalloproteases ("zincins") catalytic domain" // Astacin ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4209993 |  |
IC50 | = | 23.0 | nM | 374.29 | O=C(CN(Cc1ccc(F)c(O)c1F)Cc1ccc(F)c(O)c1F)NO | Homo sapiens | CHEMBL4189611 | assay format |
| CHEMBL4205925 |  |
IC50 | = | 24.0 | nM | 407.2 | O=C(CN(Cc1ccc(Cl)c(O)c1F)Cc1ccc(Cl)c(O)c1F)NO | Homo sapiens | CHEMBL4189611 | assay format |
| CHEMBL4216076 |  |
IC50 | = | 49.0 | nM | 358.35 | O=C(CN(Cc1cccc(C(=O)O)c1)Cc1cccc(C(=O)O)c1)NO | Homo sapiens | CHEMBL4189611 | assay format |
| CHEMBL4105563 |  |
IC50 | = | 60.0 | nM | 408.39 | O=C(CN(Cc1cccc(C(=O)O)c1)S(=O)(=O)c1cccc(C(=O)O)c1)NO | Homo sapiens | CHEMBL4018050 | assay format |
| CHEMBL4078433 |  |
IC50 | = | 60.0 | nM | 394.41 | COc1ccc(S(=O)(=O)N(CC(=O)NO)Cc2cccc(C(=O)O)c2)cc1 | Homo sapiens | CHEMBL4018050 | assay format |
| CHEMBL4206683 |  |
IC50 | = | 76.0 | nM | 348.79 | O=C(CN(Cc1ccc(Cl)cc1)Cc1cccc(C(=O)O)c1)NO | Homo sapiens | CHEMBL4189611 | assay format |
| CHEMBL4217240 |  |
IC50 | = | 77.0 | nM | 344.37 | COc1ccc(CN(CC(=O)NO)Cc2cccc(C(=O)O)c2)cc1 | Homo sapiens | CHEMBL4189611 | assay format |
| CHEMBL4207946 |  |
IC50 | = | 177.0 | nM | 332.33 | O=C(CN(Cc1ccc(F)cc1)Cc1cccc(C(=O)O)c1)NO | Homo sapiens | CHEMBL4189611 | assay format |
| CHEMBL4204835 |  |
IC50 | = | 207.0 | nM | 358.35 | O=C(CN(Cc1ccc(C(=O)O)cc1)Cc1cccc(C(=O)O)c1)NO | Homo sapiens | CHEMBL4189611 | assay format |
| CHEMBL4099123 |  |
IC50 | = | 220.0 | nM | 288.28 | O=C(CCNS(=O)(=O)c1cccc(C(=O)O)c1)NO | Homo sapiens | CHEMBL4018050 | assay format |
| CHEMBL4102689 |  |
IC50 | = | 270.0 | nM | 408.39 | O=C(CN(Cc1cccc(C(=O)O)c1)S(=O)(=O)c1ccc2c(c1)OCO2)NO | Homo sapiens | CHEMBL4018050 | assay format |
| CHEMBL4206728 |  |
IC50 | = | 272.0 | nM | 374.29 | O=C(CN(Cc1cc(F)c(O)c(F)c1)Cc1cc(F)c(O)c(F)c1)NO | Homo sapiens | CHEMBL4189611 | assay format |
| CHEMBL4215019 |  |
IC50 | = | 285.0 | nM | 358.35 | O=C(CN(Cc1cccc(C(=O)O)c1)Cc1ccc2c(c1)OCO2)NO | Homo sapiens | CHEMBL4189611 | assay format |
| CHEMBL4083600 |  |
IC50 | = | 310.0 | nM | 274.25 | O=C(CNS(=O)(=O)c1cccc(C(=O)O)c1)NO | Homo sapiens | CHEMBL4018050 | assay format |
| CHEMBL4207739 |  |
IC50 | = | 320.0 | nM | 339.35 | N#Cc1ccc(CN(CC(=O)NO)Cc2cccc(C(=O)O)c2)cc1 | Homo sapiens | CHEMBL4189611 | assay format |
| CHEMBL4087683 |  |
IC50 | = | 320.0 | nM | 408.39 | O=C(CN(Cc1cccc(C(=O)O)c1)S(=O)(=O)c1ccc(C(=O)O)cc1)NO | Homo sapiens | CHEMBL4018050 | assay format |
| CHEMBL4072148 |  |
IC50 | = | 340.0 | nM | 288.28 | O=C(CCNS(=O)(=O)c1ccc(C(=O)O)cc1)NO | Homo sapiens | CHEMBL4018050 | assay format |
| CHEMBL4218599 |  |
IC50 | = | 347.0 | nM | 380.35 | COc1cc(F)c(CN(CC(=O)NO)Cc2cccc(C(=O)O)c2)c(F)c1 | Homo sapiens | CHEMBL4189611 | assay format |
| CHEMBL4204272 |  |
IC50 | = | 375.0 | nM | 362.36 | COc1ccc(CN(CC(=O)NO)Cc2cccc(C(=O)O)c2)cc1F | Homo sapiens | CHEMBL4189611 | assay format |
| CHEMBL4210875 |  |
IC50 | = | 377.0 | nM | 224.22 | O=C(CNCc1cccc(C(=O)O)c1)NO | Homo sapiens | CHEMBL4189611 | assay format |