Q16769 | QPCT_HUMAN | Glutaminyl-peptide cyclotransferase (QPCT)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF04389 | Peptidase_M28 - Peptidase family M28 | 122~352 |
3D structures mapped by conservation among orthologs
[ Domain: "Zn-dependent exopeptidases" // Peptidase_M28 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5092802 |  |
IC50 | = | 0.1 | nM | 499.66 | COc1cc(N(CC2CCCC2)C(=O)NCCCn2cncc2C)ccc1OCCN1CCOCC1 | Homo sapiens | CHEMBL5035499 | single protein format |
| CHEMBL5085353 |  |
IC50 | = | 0.3 | nM | 510.71 | COc1cc(NC(=S)N(CCCn2cncc2C)C(C)C)ccc1OCCCCc1ccnc(N)c1 | Homo sapiens | CHEMBL5035499 | single protein format |
| CHEMBL5086776 |  |
IC50 | = | 0.46 | nM | 498.67 | COc1cc(N(CC2CCCC2)C(=O)NCCCn2cncc2C)ccc1OCCN1CCNCC1 | Homo sapiens | CHEMBL5035499 | single protein format |
| CHEMBL5085226 |  |
IC50 | = | 0.5 | nM | 536.75 | COc1cc(N(C(=S)NCCCn2cncc2C)C2CCCC2)ccc1OCCCCc1ccnc(N)c1 | Homo sapiens | CHEMBL5035499 | single protein format |
| CHEMBL5075575 |  |
IC50 | = | 0.6 | nM | 550.77 | COc1cc(N(C(=S)NCCCn2cncc2C)C2CCCCC2)ccc1OCCCCc1ccnc(N)c1 | Homo sapiens | CHEMBL5035499 | single protein format |
| CHEMBL4077433 |  |
IC50 | = | 0.7 | nM | 432.59 | COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCN1CCNCC1 | Homo sapiens | CHEMBL4009736 | single protein format |
| CHEMBL5089771 |  |
IC50 | = | 0.71 | nM | 500.69 | COc1cc(N(C(=O)NCCCn2cncc2C)C2CCN(C)CC2)ccc1OCCCCN(C)C | Homo sapiens | CHEMBL5035499 | single protein format |
| CHEMBL5083519 |  |
IC50 | = | 0.8 | nM | 522.72 | COc1cc(N(C(=S)NCCCn2cncc2C)C2CCC2)ccc1OCCCCc1ccnc(N)c1 | Homo sapiens | CHEMBL5035499 | single protein format |
| CHEMBL5085670 |  |
IC50 | = | 1.0 | nM | 512.7 | COc1cc(N(CC2CCCC2)C(=O)NCCCn2cncc2C)ccc1OCCN1CCN(C)CC1 | Homo sapiens | CHEMBL5035499 | single protein format |
| CHEMBL5088732 |  |
IC50 | = | 1.0 | nM | 542.68 | COc1cc(N(Cc2ccccc2)C(=O)NCCCn2cncc2C)ccc1OCCCCc1ccnc(N)c1 | Homo sapiens | CHEMBL5035499 | single protein format |
| CHEMBL4525926 |  |
IC50 | = | 1.3 | nM | 442.56 | COc1ccc(N(Cc2ccc(F)cc2)C(=S)NCCCn2cncc2C)cc1OC | Homo sapiens | CHEMBL4376103 | cell-based format |
| CHEMBL5089285 |  |
IC50 | = | 1.4 | nM | 524.64 | COc1cc(N(Cc2ccc(F)cc2)C(=O)NCCCn2cncc2C)ccc1OCCN1CCNCC1 | Homo sapiens | CHEMBL5035499 | single protein format |
| CHEMBL5081653 |  |
IC50 | = | 1.5 | nM | 498.67 | COc1cc(N(C(=O)NCCCn2cncc2C)C2CCCCC2)ccc1OCCN1CCNCC1 | Homo sapiens | CHEMBL5035499 | single protein format |
| CHEMBL5081891 |  |
IC50 | = | 1.6 | nM | 532.62 | COc1cc(N(Cc2ccc(F)cc2)C(=O)NCCCn2cncc2C)ccc1OCCc1ccnc(N)c1 | Homo sapiens | CHEMBL5035499 | single protein format |
| CHEMBL5083687 |  |
IC50 | = | 1.6 | nM | 513.69 | COc1cc(N(C(=O)NCCCn2cncc2C)C2CCN(C)CC2)ccc1OCCN1CCNCC1 | Homo sapiens | CHEMBL5035499 | single protein format |
| CHEMBL4445407 |  |
IC50 | = | 1.6 | nM | 509.66 | COc1ccc(N(CCCCc2ccnc(NCCN)c2)C(=O)NCCCn2cncc2C)cc1OC | Homo sapiens | CHEMBL4376103 | cell-based format |
| CHEMBL5081537 |  |
IC50 | = | 1.7 | nM | 506.65 | COc1cc(N(C(=O)NCCCn2cncc2C)C2CCCCC2)ccc1OCCc1ccnc(N)c1 | Homo sapiens | CHEMBL5035499 | single protein format |
| CHEMBL5092925 |  |
IC50 | = | 1.8 | nM | 527.71 | COc1cc(N(C(=O)NCCCn2cncc2C)C2CCN(C)CC2)ccc1OCCN1CCN(C)CC1 | Homo sapiens | CHEMBL5035499 | single protein format |
| CHEMBL4204093 |  |
IC50 | = | 1.8 | nM | 511.7 | COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCCCc1ccnc(NCCN)c1 | Homo sapiens | CHEMBL4188043 | single protein format |
| CHEMBL5266674 |  |
IC50 | = | 2.3 | nM | 434.52 | Cc1nn(C)c2cc(N(Cc3ccc(F)cc3)C(=O)NCCCn3cncc3C)ccc12 | Homo sapiens | CHEMBL5249644 | single protein format |