Q16665 | HIF1A_HUMAN | Hypoxia-inducible factor 1-alpha (HIF1A)

Pfam Domain Table

AccessionDomainRangeColor
PF00989PAS - PAS fold94~149
PF08447PAS_3 - PAS fold254~339
PF08778HIF-1a_CTAD - HIF-1 alpha C terminal transactivation domain790~825
PF11413HIF-1 - Hypoxia-inducible factor-1555~580
PF23171bHLH_HIF1A - Hypoxia-inducible factor 1-alpha bHLH domain1~80

3D structures mapped by conservation among orthologs

[ Domain: "sensor domains" // PAS_11 ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL380456 IC50 = 0.65 nM 326.35 CC1(C)Oc2cc3oc(-c4cc(O)cc(O)c4)cc3cc2CC1O Homo sapiens CHEMBL3399575 cell-based format
CHEMBL283631 IC50 = 1.0 nM 520.49 COc1cc([C@@H]2c3cc4c(cc3[C@@H](Nc3ccc([N+](=O)[O-])cc3)[C@H]3COC(=O)[C@H]23)OCO4)cc(OC)c1O Homo sapiens CHEMBL4396991 cell-based format
CHEMBL1795446 IC50 = 1.0 nM 310.35 CC(C)(O)[C@H]1Cc2cc3cc(-c4ccc(O)cc4)oc3cc2O1 Homo sapiens CHEMBL1799182 cell-based format
CHEMBL2205734 IC50 = 3.0 nM 412.92 Cc1ccc(Cn2nc(-c3nc4ccc(-c5ccc(Cl)cc5)cc4[nH]3)cc2C)cc1 Homo sapiens CHEMBL2212528 cell-based format
CHEMBL1795435 IC50 = 4.2 nM 310.35 CC(C)(O)C1Cc2cc3cc(-c4ccc(O)cc4)oc3cc2O1 Homo sapiens CHEMBL1799182 cell-based format
CHEMBL1795432 IC50 = 6.76 nM 326.35 CC(C)(O)[C@H]1Cc2cc3cc(-c4cc(O)cc(O)c4)oc3cc2O1 Homo sapiens CHEMBL1799182 cell-based format
CHEMBL205924 IC50 = 6.76 nM 326.35 CC(C)(O)C1Cc2cc3cc(-c4cc(O)cc(O)c4)oc3cc2O1 Homo sapiens CHEMBL1799182 cell-based format
CHEMBL1795439 IC50 = 7.0 nM 324.38 COc1cccc(-c2cc3cc4c(cc3o2)OC(C(C)(C)O)C4)c1 Homo sapiens CHEMBL1799182 cell-based format
CHEMBL1795433 IC50 = 10.0 nM 354.4 COc1cc(OC)cc(-c2cc3cc4c(cc3o2)OC(C(C)(C)O)C4)c1 Homo sapiens CHEMBL1799182 cell-based format
CHEMBL561971 IC50 = 10.7 nM 326.35 CC1(C)Oc2cc3oc(-c4cc(O)cc(O)c4)cc3cc2C[C@H]1O Homo sapiens CHEMBL1799182 cell-based format
CHEMBL2323956 IC50 = 14.0 nM 305.34 c1ccc2c(c1)Cc1c(Nc3ccc4c(c3)OCCO4)n[nH]c1-2 Homo sapiens CHEMBL2327238 cell-based format
CHEMBL3105545 IC50 = 20.0 nM 552.66 COc1ccc([C@@H](O)[C@@H](C)Oc2ccc([C@H]3O[C@H](c4ccc(OC)c(OC)c4)[C@H](C)[C@H]3C)cc2OC)cc1OC Homo sapiens CHEMBL4344026 cell-based format
CHEMBL4434875 IC50 = 22.8 nM 523.63 COc1ccc([C@@H](O)[C@@H](C)Oc2ccc([C@@H]3CCN(c4ccc(OC)c(OC)c4)C3)cc2OC)cc1OC Homo sapiens CHEMBL4344026 cell-based format
CHEMBL5184354 IC50 = 24.0 nM 280.28 CC(=O)c1ccc(NC(=O)c2noc3ccccc23)cc1 Homo sapiens CHEMBL5120693 cell-based format
CHEMBL5205360 IC50 = 24.0 nM 281.32 CN(C)c1ccc(NC(=O)c2noc3ccccc23)cc1 Homo sapiens CHEMBL5120693 cell-based format
CHEMBL2323957 IC50 = 34.0 nM 335.36 COc1cccc2c1Cc1c(Nc3ccc4c(c3)OCCO4)n[nH]c1-2 Homo sapiens CHEMBL2327238 cell-based format
CHEMBL5208153 IC50 = 40.0 nM 268.27 COc1ccc(NC(=O)c2noc3ccccc23)cc1 Homo sapiens CHEMBL5120693 cell-based format
CHEMBL5194403 IC50 = 41.0 nM 272.69 O=C(Nc1ccc(Cl)cc1)c1noc2ccccc12 Homo sapiens CHEMBL5120693 cell-based format
CHEMBL5197796 IC50 = 42.0 nM 295.32 O=C(Nc1ccc2scnc2c1)c1noc2ccccc12 Homo sapiens CHEMBL5120693 cell-based format
CHEMBL1337170 IC50 = 43.0 nM 211.2 O=[N+]([O-])c1ccc2c(c1)S(=O)(=O)C=C2 Homo sapiens CHEMBL4481809 single protein format