Q16665 | HIF1A_HUMAN | Hypoxia-inducible factor 1-alpha (HIF1A)
Pfam Domain Table
Accession | Domain | Range | Color |
---|---|---|---|
PF00989 | PAS - PAS fold | 94~149 | |
PF08447 | PAS_3 - PAS fold | 254~339 | |
PF08778 | HIF-1a_CTAD - HIF-1 alpha C terminal transactivation domain | 790~825 | |
PF11413 | HIF-1 - Hypoxia-inducible factor-1 | 555~580 | |
PF23171 | bHLH_HIF1A - Hypoxia-inducible factor 1-alpha bHLH domain | 1~80 |
3D structures mapped by conservation among orthologs
[ Domain: "sensor domains" // PAS_11 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
---|---|---|---|---|---|---|---|---|---|---|
CHEMBL380456 | IC50 | = | 0.65 | nM | 326.35 | CC1(C)Oc2cc3oc(-c4cc(O)cc(O)c4)cc3cc2CC1O | Homo sapiens | CHEMBL3399575 | cell-based format | |
CHEMBL283631 | IC50 | = | 1.0 | nM | 520.49 | COc1cc([C@@H]2c3cc4c(cc3[C@@H](Nc3ccc([N+](=O)[O-])cc3)[C@H]3COC(=O)[C@H]23)OCO4)cc(OC)c1O | Homo sapiens | CHEMBL4396991 | cell-based format | |
CHEMBL1795446 | IC50 | = | 1.0 | nM | 310.35 | CC(C)(O)[C@H]1Cc2cc3cc(-c4ccc(O)cc4)oc3cc2O1 | Homo sapiens | CHEMBL1799182 | cell-based format | |
CHEMBL2205734 | IC50 | = | 3.0 | nM | 412.92 | Cc1ccc(Cn2nc(-c3nc4ccc(-c5ccc(Cl)cc5)cc4[nH]3)cc2C)cc1 | Homo sapiens | CHEMBL2212528 | cell-based format | |
CHEMBL1795435 | IC50 | = | 4.2 | nM | 310.35 | CC(C)(O)C1Cc2cc3cc(-c4ccc(O)cc4)oc3cc2O1 | Homo sapiens | CHEMBL1799182 | cell-based format | |
CHEMBL1795432 | IC50 | = | 6.76 | nM | 326.35 | CC(C)(O)[C@H]1Cc2cc3cc(-c4cc(O)cc(O)c4)oc3cc2O1 | Homo sapiens | CHEMBL1799182 | cell-based format | |
CHEMBL205924 | IC50 | = | 6.76 | nM | 326.35 | CC(C)(O)C1Cc2cc3cc(-c4cc(O)cc(O)c4)oc3cc2O1 | Homo sapiens | CHEMBL1799182 | cell-based format | |
CHEMBL1795439 | IC50 | = | 7.0 | nM | 324.38 | COc1cccc(-c2cc3cc4c(cc3o2)OC(C(C)(C)O)C4)c1 | Homo sapiens | CHEMBL1799182 | cell-based format | |
CHEMBL1795433 | IC50 | = | 10.0 | nM | 354.4 | COc1cc(OC)cc(-c2cc3cc4c(cc3o2)OC(C(C)(C)O)C4)c1 | Homo sapiens | CHEMBL1799182 | cell-based format | |
CHEMBL561971 | IC50 | = | 10.7 | nM | 326.35 | CC1(C)Oc2cc3oc(-c4cc(O)cc(O)c4)cc3cc2C[C@H]1O | Homo sapiens | CHEMBL1799182 | cell-based format | |
CHEMBL2323956 | IC50 | = | 14.0 | nM | 305.34 | c1ccc2c(c1)Cc1c(Nc3ccc4c(c3)OCCO4)n[nH]c1-2 | Homo sapiens | CHEMBL2327238 | cell-based format | |
CHEMBL3105545 | IC50 | = | 20.0 | nM | 552.66 | COc1ccc([C@@H](O)[C@@H](C)Oc2ccc([C@H]3O[C@H](c4ccc(OC)c(OC)c4)[C@H](C)[C@H]3C)cc2OC)cc1OC | Homo sapiens | CHEMBL4344026 | cell-based format | |
CHEMBL4434875 | IC50 | = | 22.8 | nM | 523.63 | COc1ccc([C@@H](O)[C@@H](C)Oc2ccc([C@@H]3CCN(c4ccc(OC)c(OC)c4)C3)cc2OC)cc1OC | Homo sapiens | CHEMBL4344026 | cell-based format | |
CHEMBL5184354 | IC50 | = | 24.0 | nM | 280.28 | CC(=O)c1ccc(NC(=O)c2noc3ccccc23)cc1 | Homo sapiens | CHEMBL5120693 | cell-based format | |
CHEMBL5205360 | IC50 | = | 24.0 | nM | 281.32 | CN(C)c1ccc(NC(=O)c2noc3ccccc23)cc1 | Homo sapiens | CHEMBL5120693 | cell-based format | |
CHEMBL2323957 | IC50 | = | 34.0 | nM | 335.36 | COc1cccc2c1Cc1c(Nc3ccc4c(c3)OCCO4)n[nH]c1-2 | Homo sapiens | CHEMBL2327238 | cell-based format | |
CHEMBL5208153 | IC50 | = | 40.0 | nM | 268.27 | COc1ccc(NC(=O)c2noc3ccccc23)cc1 | Homo sapiens | CHEMBL5120693 | cell-based format | |
CHEMBL5194403 | IC50 | = | 41.0 | nM | 272.69 | O=C(Nc1ccc(Cl)cc1)c1noc2ccccc12 | Homo sapiens | CHEMBL5120693 | cell-based format | |
CHEMBL5197796 | IC50 | = | 42.0 | nM | 295.32 | O=C(Nc1ccc2scnc2c1)c1noc2ccccc12 | Homo sapiens | CHEMBL5120693 | cell-based format | |
CHEMBL1337170 | IC50 | = | 43.0 | nM | 211.2 | O=[N+]([O-])c1ccc2c(c1)S(=O)(=O)C=C2 | Homo sapiens | CHEMBL4481809 | single protein format |