Q16659 | MK06_HUMAN | Mitogen-activated protein kinase 6 (MAPK6)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 20~316 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4741134 |  |
IC50 | = | 55.0 | nM | 419.49 | CCOc1ccc(-n2nnc3cnc(Nc4cnn(C5CCN(C)CC5)c4)nc32)cc1 | Homo sapiens | CHEMBL4702185 | cell-based format |
| CHEMBL4755149 |  |
IC50 | = | 93.0 | nM | 388.44 | COc1ccc(-n2nnc3cnc(N[C@@H]4CCN(c5ccncc5)C4)nc32)cc1 | Homo sapiens | CHEMBL4702185 | cell-based format |
| CHEMBL4786970 |  |
IC50 | = | 110.0 | nM | 379.43 | CN1CCC(n2cc(Nc3ncc4nnn(-c5ccn(C)n5)c4n3)cn2)CC1 | Homo sapiens | CHEMBL4702185 | cell-based format |
| CHEMBL4784697 |  |
IC50 | = | 227.0 | nM | 353.43 | COc1ccc(-n2nnc3cnc(N[C@H]4CC[C@H](CN)CC4)nc32)cc1 | Homo sapiens | CHEMBL4702185 | cell-based format |
| CHEMBL4757911 |  |
IC50 | = | 244.0 | nM | 418.44 | CN1CCC(n2cc(Nc3ncc4nnn(-c5ccc(F)cc5C#N)c4n3)cn2)CC1 | Homo sapiens | CHEMBL4702185 | cell-based format |
| CHEMBL4740226 |  |
IC50 | = | 274.0 | nM | 325.38 | COc1ccc(-n2nnc3cnc(N[C@@H]4CC[C@@H](N)C4)nc32)cc1 | Homo sapiens | CHEMBL4702185 | cell-based format |
| CHEMBL4759319 |  |
IC50 | = | 504.0 | nM | 339.4 | COc1ccc(-n2nnc3cnc(N[C@H]4CC[C@H](N)CC4)nc32)cc1 | Homo sapiens | CHEMBL4702185 | cell-based format |
| CHEMBL4753751 |  |
IC50 | = | 1000.0 | nM | 325.38 | COc1ccc(-n2nnc3cnc(N[C@@H]4CC[C@H](N)C4)nc32)cc1 | Homo sapiens | CHEMBL4702186 | cell-based format |