Q16658 | FSCN1_HUMAN | Fascin (FSCN1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF06268 | Fascin - Fascin domain | 21~134 | |
| PF06268 | Fascin - Fascin domain | 143~256 | |
| PF06268 | Fascin - Fascin domain | 268~377 | |
| PF06268 | Fascin - Fascin domain | 392~493 |
3D structures mapped by conservation among orthologs
[ Domain: "beta-Trefoil" // Fascin_1 ]
[ Domain: "beta-Trefoil" // Fascin_3 ]
[ Domain: "beta-Trefoil" // Fascin ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4452711 |  |
IC50 | = | 240.0 | nM | 497.39 | O=C(Nc1ccncc1)c1cn(Cc2ccc(Cl)c(Cl)c2)c(=O)c2cnn(C3CCNCC3)c12 | Homo sapiens | CHEMBL4401535 | assay format |
| CHEMBL4461540 |  |
IC50 | = | 330.0 | nM | 532.41 | O=C(Nc1ccncc1)c1cn(Cc2ccc(Cl)c(Cl)c2)c(=O)c2cnn(C3CCS(=O)(=O)C3)c12 | Homo sapiens | CHEMBL4401535 | assay format |
| CHEMBL1188627 |  |
IC50 | = | 500.0 | nM | 267.36 | C/N=c1/nc(-c2ccccc2)n(-c2ccccc2)s1 | Homo sapiens | CHEMBL4482465 | assay format |
| CHEMBL3559101 |  |
IC50 | = | 500.0 | nM | 268.37 | CNc1nc(-c2ccccc2)[n+](-c2ccccc2)s1 | Homo sapiens | CHEMBL4482465 | assay format |
| CHEMBL4574198 |  |
IC50 | = | 510.0 | nM | 511.41 | Cn1cc(NC(=O)c2cn(Cc3ccc(Cl)c(Cl)c3)c(=O)c3cnc(N4CCCCC4)cc23)cn1 | Homo sapiens | CHEMBL4401535 | assay format |
| CHEMBL3235902 |  |
IC50 | = | 539.0 | nM | 440.55 | Cc1cc(C)c(S(=O)(=O)Nc2cc(Sc3nc[nH]n3)c(O)c3ccccc23)cc1C | Homo sapiens | CHEMBL4482465 | assay format |
| CHEMBL4559691 |  |
IC50 | = | 630.0 | nM | 512.4 | Cn1cc(NC(=O)c2cn(Cc3ccc(Cl)c(Cl)c3)c(=O)c3cnc(N4CCNCC4)cc23)cn1 | Homo sapiens | CHEMBL4401535 | assay format |
| CHEMBL4566108 |  |
IC50 | = | 630.0 | nM | 535.41 | Cn1cc(NC(=O)c2cn(Cc3ccc(Cl)c(Cl)c3)c(=O)c3cnn(C4CCS(=O)(=O)C4)c23)cn1 | Homo sapiens | CHEMBL4401535 | assay format |
| CHEMBL4539339 |  |
IC50 | = | 652.0 | nM | 404.26 | O=[N+]([O-])c1ccc(Cl)c(S(=O)(=O)Nc2nc3ccc(Cl)cc3s2)c1 | Homo sapiens | CHEMBL4482465 | assay format |
| CHEMBL4526942 |  |
IC50 | = | 683.0 | nM | 426.52 | Cc1ccc(C)c(S(=O)(=O)Nc2cc(Sc3nc[nH]n3)c(O)c3ccccc23)c1 | Homo sapiens | CHEMBL4482465 | assay format |
| CHEMBL4440859 |  |
IC50 | = | 734.0 | nM | 413.29 | O=c1c2cnn(C3CCS(=O)(=O)C3)c2ncn1Cc1ccc(Cl)c(Cl)c1 | Homo sapiens | CHEMBL4482465 | assay format |
| CHEMBL1540929 |  |
IC50 | = | 807.0 | nM | 428.5 | COc1ccc(S(=O)(=O)Nc2cc(Sc3nc[nH]n3)c(O)c3ccccc23)cc1 | Homo sapiens | CHEMBL4482465 | assay format |
| CHEMBL4524644 |  |
IC50 | = | 890.0 | nM | 426.52 | CCc1ccc(S(=O)(=O)Nc2cc(Sc3nc[nH]n3)c(O)c3ccccc23)cc1 | Homo sapiens | CHEMBL4482465 | assay format |