Q16654 | PDK4_HUMAN | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial (PDK4)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF02518 | HATPase_c - Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase | 245~365 | |
| PF10436 | BCDHK_Adom3 - Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase | 34~195 |
3D structures mapped by conservation among orthologs
[ Domain: "alpha-ketoacid dehydrogenase kinase-N" // BCDHK_Adom3 ]
[ Domain: "ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase" // HATPase_c ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4591977 |  |
IC50 | = | 5.0 | nM | 475.36 | CN(C)C(=O)c1ccc(N(Cc2cc(Br)cs2)C(=O)c2ccc(O)cc2O)cc1 | Homo sapiens | CHEMBL4403262 | single protein format |
| CHEMBL4551410 |  |
IC50 | = | 8.0 | nM | 475.36 | CN(C)C(=O)c1ccc(N(Cc2ccc(Br)s2)C(=O)c2ccc(O)cc2O)cc1 | Homo sapiens | CHEMBL4403262 | single protein format |
| CHEMBL4519504 |  |
IC50 | = | 11.0 | nM | 506.3 | CN(C)C(=O)c1ccc(N(Cc2ccc(I)o2)C(=O)c2ccc(O)cc2O)cc1 | Homo sapiens | CHEMBL4403262 | single protein format |
| CHEMBL5087040 |  |
IC50 | = | 12.2 | nM | 431.5 | Cc1nc(N2C[C@@H](c3ccc(C(=O)O)[nH]3)C[C@H]2CO)c2c(n1)[nH]c1c(C3CC3)cccc12 | Homo sapiens | CHEMBL5057866 | single protein format |
| CHEMBL4575355 |  |
IC50 | = | 13.0 | nM | 459.3 | CN(C)C(=O)c1ccc(N(Cc2ccc(Br)o2)C(=O)c2ccc(O)cc2O)cc1 | Homo sapiens | CHEMBL4403262 | single protein format |
| CHEMBL5072731 |  |
IC50 | = | 17.8 | nM | 430.51 | Cc1nc(N2C[C@@H](c3ccc(C(N)=O)[nH]3)C[C@H]2CO)c2c(n1)[nH]c1c(C3CC3)cccc12 | Homo sapiens | CHEMBL5057866 | single protein format |
| CHEMBL4461160 |  |
IC50 | = | 20.0 | nM | 476.35 | CN(C)C(=O)c1ccc(N(Cc2ncc(Br)s2)C(=O)c2ccc(O)cc2O)cc1 | Homo sapiens | CHEMBL4403262 | single protein format |
| CHEMBL5079107 |  |
IC50 | = | 24.1 | nM | 493.61 | Cc1nc2[nH]c3c(C4CC4)cccc3c2cc1-c1nnc(C(NC(=O)CCc2ccccc2)C(C)C)o1 | Homo sapiens | CHEMBL5057866 | single protein format |
| CHEMBL5087238 |  |
IC50 | = | 32.9 | nM | 493.61 | Cc1nc2[nH]c3c(C4CC4)cccc3c2cc1-c1nnc(C(CC(=O)NCc2ccccc2)C(C)C)o1 | Homo sapiens | CHEMBL5057866 | single protein format |
| CHEMBL4540811 |  |
IC50 | = | 34.0 | nM | 406.44 | CN(C)C(=O)c1ccc(N(Cc2ccc(O)cc2)C(=O)c2ccc(O)cc2O)cc1 | Homo sapiens | CHEMBL4403262 | single protein format |
| CHEMBL5089800 |  |
IC50 | = | 40.6 | nM | 429.52 | CC[C@@H]1C[C@H](c2ccc(C(=O)O)[nH]2)CN1c1nc(C)nc2[nH]c3c(C4CC4)cccc3c12 | Homo sapiens | CHEMBL5057866 | single protein format |
| CHEMBL4558944 |  |
IC50 | = | 52.0 | nM | 408.43 | CN(C)C(=O)c1ccc(N(Cc2ccc(F)cc2)C(=O)c2ccc(O)cc2O)cc1 | Homo sapiens | CHEMBL4403262 | single protein format |
| CHEMBL4558837 |  |
IC50 | = | 52.0 | nM | 394.43 | Cc1ccc(CN(C(=O)c2ccc(O)cc2O)c2ccc(C(=O)N(C)C)cc2)o1 | Homo sapiens | CHEMBL4403262 | single protein format |
| CHEMBL5090085 |  |
IC50 | = | 61.5 | nM | 507.64 | Cc1nc2[nH]c3c(C4CC4)cccc3c2cc1-c1nnc([C@@H](CC(=O)N[C@H](C)c2ccccc2)C(C)C)o1 | Homo sapiens | CHEMBL5057866 | single protein format |
| CHEMBL3729572 |  |
IC50 | = | 66.0 | nM | 390.44 | CN(C)C(=O)c1ccc(N(Cc2ccccc2)C(=O)c2ccc(O)cc2O)cc1 | Homo sapiens | CHEMBL4403262 | single protein format |
| CHEMBL4570690 |  |
IC50 | = | 69.0 | nM | 380.4 | CN(C)C(=O)c1ccc(N(Cc2ccco2)C(=O)c2ccc(O)cc2O)cc1 | Homo sapiens | CHEMBL4403262 | single protein format |
| CHEMBL4587341 |  |
IC50 | = | 82.0 | nM | 414.85 | CN(C)C(=O)c1ccc(N(Cc2ccc(Cl)o2)C(=O)c2ccc(O)cc2O)cc1 | Homo sapiens | CHEMBL4403262 | single protein format |
| CHEMBL4471264 |  |
IC50 | = | 84.0 | nM | 393.87 | Cl.O=C1c2ccccc2C(=O)c2c1cccc2-c1cnn(C2CCNCC2)c1 | Homo sapiens | CHEMBL4333048 | single protein format |
| CHEMBL4452536 |  |
IC50 | = | 87.0 | nM | 476.35 | CN(C)C(=O)c1ccc(N(Cc2cnc(Br)s2)C(=O)c2ccc(O)cc2O)cc1 | Homo sapiens | CHEMBL4403262 | single protein format |
| CHEMBL4513465 |  |
IC50 | = | 89.0 | nM | 421.48 | CN(C)C(=O)c1ccc(N(Cc2ccc(C#N)s2)C(=O)c2ccc(O)cc2O)cc1 | Homo sapiens | CHEMBL4403262 | single protein format |