Q16584 | M3K11_HUMAN | Mitogen-activated protein kinase kinase kinase 11 (MAP3K11)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 118~376 | |
| PF14604 | SH3_9 - Variant SH3 domain | 48~100 |
3D structures mapped by conservation among orthologs
[ Domain: "SH3" // SH3_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2436980 |  |
IC50 | = | 3.0 | nM | 399.45 | COc1cc(-c2cnc3[nH]cc(-c4ccc5[nH]ccc5c4)c3c2)cc(OC)c1OC | Homo sapiens | CHEMBL2437703 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 4.0 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328504 | single protein format |
| CHEMBL281948 |  |
IC50 | = | 5.0 | nM | 467.48 | COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL5336404 | single protein format |
| CHEMBL2436982 |  |
IC50 | = | 7.0 | nM | 376.42 | COc1cc(-c2cnc3[nH]cc(-c4ccc(N)nc4)c3c2)cc(OC)c1OC | Homo sapiens | CHEMBL2437703 | single protein format |
| CHEMBL4218417 |  |
IC50 | = | 7.0 | nM | 427.5 | CC(C)OCc1ccc2c(c1)c1c3c(c4c5ccccc5[nH]c4c1n2CCO)CNC3=O | Homo sapiens | CHEMBL4199317 | assay format |
| CHEMBL2436976 |  |
IC50 | = | 9.0 | nM | 377.4 | COc1cc(-c2cnc3[nH]cc(-c4cnc(N)nc4)c3c2)cc(OC)c1OC | Homo sapiens | CHEMBL2437703 | single protein format |
| CHEMBL289772 |  |
IC50 | = | 11.0 | nM | 527.53 | COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccc(CO)cc3c3c4c(c5c6cc(CO)ccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL732491 | single protein format |
| CHEMBL277817 |  |
IC50 | = | 11.0 | nM | 583.64 | CCOCc1ccc2c(c1)c1c3c(c4c5cc(COCC)ccc5n5c4c1n2[C@H]1C[C@](O)(C(=O)OC)[C@]5(C)O1)CNC3=O | Homo sapiens | CHEMBL732491 | single protein format |
| CHEMBL288817 |  |
IC50 | = | 11.0 | nM | 555.59 | COCc1ccc2c(c1)c1c3c(c4c5cc(COC)ccc5n5c4c1n2[C@H]1C[C@](O)(C(=O)OC)[C@]5(C)O1)CNC3=O | Homo sapiens | CHEMBL732491 | single protein format |
| CHEMBL386636 |  |
IC50 | = | 12.0 | nM | 338.37 | O=C1NC(=O)c2c1c1c(c3[nH]c4ccccc4c23)CCc2ccccc2-1 | Homo sapiens | CHEMBL911979 | assay format |
| CHEMBL416056 |  |
IC50 | = | 13.0 | nM | 467.48 | COC(=O)[C@]1(O)C[C@@H]2O[C@@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL911979 | assay format |
| CHEMBL2436978 |  |
IC50 | = | 14.0 | nM | 421.55 | CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5ccc6[nH]ccc6c5)c4c3)cc2)CC1 | Homo sapiens | CHEMBL2437703 | single protein format |
| CHEMBL2436981 |  |
IC50 | = | 19.0 | nM | 325.38 | Nc1ccc(-c2cnc3[nH]cc(-c4ccc5[nH]ccc5c4)c3c2)cn1 | Homo sapiens | CHEMBL2437703 | single protein format |
| CHEMBL288229 |  |
IC50 | = | 21.0 | nM | 541.63 | CCSCc1ccc2c(c1)c1c3c(c4c5ccccc5n5c4c1n2[C@@]1(C)O[C@@H]5C[C@]1(O)C(=O)OC)C(=O)NC3 | Homo sapiens | CHEMBL732491 | single protein format |
| CHEMBL2436977 |  |
IC50 | = | 21.0 | nM | 422.54 | CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5cnc6[nH]ccc6c5)c4c3)cc2)CC1 | Homo sapiens | CHEMBL2437703 | single protein format |
| CHEMBL374581 |  |
IC50 | = | 22.0 | nM | 324.38 | O=C1NCc2c3c(c4[nH]c5ccccc5c4c21)CCc1ccccc1-3 | Homo sapiens | CHEMBL911979 | assay format |
| CHEMBL5413518 |  |
IC50 | = | 23.7 | nM | 446.98 | OCCN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5cccc(Cl)c5)c4c3)cc2)CC1 | Homo sapiens | CHEMBL5336409 | single protein format |
| CHEMBL221536 |  |
IC50 | = | 26.0 | nM | 328.4 | O=C1NCc2c1c1c3ccccc3sc1c1[nH]c3ccccc3c21 | Homo sapiens | CHEMBL911979 | assay format |
| CHEMBL357490 |  |
IC50 | = | 40.0 | nM | 310.36 | O=C1NCc2c1c1c(c3[nH]c4ccccc4c23)Cc2ccccc2-1 | Homo sapiens | CHEMBL911979 | assay format |
| CHEMBL2436979 |  |
IC50 | = | 40.0 | nM | 417.43 | COc1cc(-c2cnc3[nH]c(=O)n(-c4ccc5[nH]ccc5c4)c3n2)cc(OC)c1OC | Homo sapiens | CHEMBL2437703 | single protein format |