Q16581 | C3AR_HUMAN | C3a anaphylatoxin chemotactic receptor (C3AR1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 40~179 | |
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 333~435 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4470864 |  |
IC50 | = | 2.0 | nM | 464.59 | Cc1cc(C(c2ccccc2)c2ccccc2)sc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | Homo sapiens | CHEMBL4380993 | cell-based format |
| CHEMBL4576800 |  |
IC50 | = | 4.0 | nM | 450.56 | N=C(N)NCCC[C@H](NC(=O)c1ccc(C(c2ccccc2)c2ccccc2)s1)C(=O)O | Homo sapiens | CHEMBL4380993 | cell-based format |
| CHEMBL3735507 |  |
IC50 | = | 5.0 | nM | 538.4 | CC[C@H](C)[C@H](NC(=O)c1cncc(Br)c1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | Homo sapiens | CHEMBL3738948 | cell-based format |
| CHEMBL3342688 |  |
IC50 | = | 7.0 | nM | 434.5 | N=C(N)NCCC[C@H](NC(=O)c1c[nH]c(C(c2ccccc2)c2ccccc2)n1)C(=O)O | Homo sapiens | CHEMBL3387987 | single protein format |
| CHEMBL3342676 |  |
IC50 | = | 8.0 | nM | 428.56 | N=C(N)NCCC[C@H](NC(=O)CSCC(c1ccccc1)c1ccccc1)C(=O)O | Homo sapiens | CHEMBL3387987 | single protein format |
| CHEMBL4459627 |  |
IC50 | = | 8.0 | nM | 533.48 | Cc1cc(C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)sc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | Homo sapiens | CHEMBL4380993 | cell-based format |
| CHEMBL3736108 |  |
IC50 | = | 9.0 | nM | 497.56 | CC(C)C[C@H](NC(=O)c1c[nH]c2ccccc12)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | Homo sapiens | CHEMBL3738948 | cell-based format |
| CHEMBL3735614 |  |
IC50 | = | 10.0 | nM | 413.47 | NC(=O)NCCC[C@H](NC(=O)COCC(c1ccccc1)c1ccccc1)C(=O)O | Homo sapiens | CHEMBL3739131 | cell-based format |
| CHEMBL3342689 |  |
IC50 | = | 10.0 | nM | 448.53 | Cc1[nH]c(C(c2ccccc2)c2ccccc2)nc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | Homo sapiens | CHEMBL3387987 | single protein format |
| CHEMBL3342686 |  |
IC50 | = | 11.0 | nM | 449.51 | Cc1oc(C(c2ccccc2)c2ccccc2)nc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | Homo sapiens | CHEMBL3387987 | single protein format |
| CHEMBL3342680 |  |
IC50 | = | 12.0 | nM | 436.47 | N=C(N)NCCC[C@H](NC(=O)c1nc(C(c2ccccc2)c2ccccc2)no1)C(=O)O | Homo sapiens | CHEMBL3387987 | single protein format |
| CHEMBL3735339 |  |
IC50 | = | 14.0 | nM | 468.56 | Cc1oc([C@H](CC(C)C)NC(=O)OC(C)(C)C)nc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | Homo sapiens | CHEMBL3738948 | cell-based format |
| CHEMBL3342685 |  |
IC50 | = | 19.0 | nM | 435.48 | N=C(N)NCCC[C@H](NC(=O)c1coc(C(c2ccccc2)c2ccccc2)n1)C(=O)O | Homo sapiens | CHEMBL3387987 | single protein format |
| CHEMBL3735760 |  |
IC50 | = | 20.0 | nM | 454.53 | CC(C)C[C@H](NC(=O)OC(C)(C)C)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | Homo sapiens | CHEMBL3738948 | cell-based format |
| CHEMBL3736519 |  |
IC50 | = | 27.0 | nM | 458.52 | CC[C@H](C)[C@H](NC(=O)c1ccccc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | Homo sapiens | CHEMBL3738948 | cell-based format |
| CHEMBL3736239 |  |
IC50 | = | 30.0 | nM | 454.53 | CC[C@H](C)[C@H](NC(=O)OC(C)(C)C)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | Homo sapiens | CHEMBL3738948 | cell-based format |
| CHEMBL3342690 |  |
IC50 | = | 31.0 | nM | 462.55 | Cc1c(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)nc(C(c2ccccc2)c2ccccc2)n1C | Homo sapiens | CHEMBL3387987 | single protein format |
| CHEMBL4239466 |  |
IC50 | = | 50.0 | nM | 464.32 | N=C(N)NCCC[C@H](NC(=O)c1cccn(Cc2ccccc2Br)c1=O)C(=O)O | Homo sapiens | CHEMBL4229730 | cell-based format |
| CHEMBL3342681 |  |
IC50 | = | 54.0 | nM | 436.47 | N=C(N)NCCC[C@H](NC(=O)c1noc(C(c2ccccc2)c2ccccc2)n1)C(=O)O | Homo sapiens | CHEMBL3387987 | single protein format |
| CHEMBL3735764 |  |
IC50 | = | 55.0 | nM | 550.62 | CC[C@H](C)[C@H](NC(=O)c1ccccc1Oc1ccccc1)c1nc(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)co1 | Homo sapiens | CHEMBL3738948 | cell-based format |