Q16572 | VACHT_HUMAN | Vesicular acetylcholine transporter (SLC18A3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF07690 | MFS_1 - Major Facilitator Superfamily | 96~422 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL20721 |  |
IC50 | = | 10.0 | nM | 313.49 | OC1CC2CCCCC2CC1N1CCC(c2ccccc2)CC1 | Homo sapiens | CHEMBL636849 | single protein format |
| CHEMBL207303 |  |
IC50 | = | 11.0 | nM | 430.39 | OC1CN(Cc2ccccc2Br)CCC1N1CCN(c2ccccc2)CC1 | Homo sapiens | CHEMBL870017 | cell-based format |
| CHEMBL197027 |  |
IC50 | = | 12.0 | nM | 574.35 | C[N+]1(C)CCOC(O)(c2ccc(-c3ccc(C4(O)C[N+](C)(C)CCO4)cc3)cc2)C1.[Br-].[Br-] | Homo sapiens | CHEMBL883394 | single protein format |
| CHEMBL20730 |  |
IC50 | = | 20.0 | nM | 259.39 | O[C@@H]1CCCC[C@H]1N1CCC(c2ccccc2)CC1 | Homo sapiens | CHEMBL636849 | single protein format |
| CHEMBL20463 |  |
IC50 | = | 20.0 | nM | 315.5 | CC(C)(C)[C@H]1CC[C@@H](O)[C@H](N2CCC(c3ccccc3)CC2)C1 | Homo sapiens | CHEMBL636849 | single protein format |
| CHEMBL172975 |  |
IC50 | = | 34.0 | nM | 364.49 | O=C(c1ccccc1)N1CC[C@@H](O)[C@H](N2CCC(c3ccccc3)CC2)C1 | Homo sapiens | CHEMBL2050140 | single protein format |
| CHEMBL21309 |  |
IC50 | = | 40.0 | nM | 265.44 | OC1CCCCC1N1CCC(C2CCCCC2)CC1 | Homo sapiens | CHEMBL636849 | single protein format |
| CHEMBL20943 |  |
IC50 | = | 40.0 | nM | 259.39 | OC1CCCCC1N1CCC(c2ccccc2)CC1 | Homo sapiens | CHEMBL636849 | single protein format |
| CHEMBL207342 |  |
IC50 | = | 46.0 | nM | 430.39 | OC1CCN(Cc2cccc(Br)c2)CC1N1CCN(c2ccccc2)CC1 | Homo sapiens | CHEMBL870017 | cell-based format |
| CHEMBL207191 |  |
IC50 | = | 47.0 | nM | 430.39 | OC1CCN(Cc2ccccc2Br)CC1N1CCN(c2ccccc2)CC1 | Homo sapiens | CHEMBL870017 | cell-based format |
| CHEMBL20382 |  |
IC50 | = | 50.0 | nM | 422.53 | O=C(O)CCC(=O)Nc1cccc2c1CC(N1CCC(c3ccccc3)CC1)C(O)C2 | Homo sapiens | CHEMBL636849 | single protein format |
| CHEMBL21151 |  |
IC50 | = | 50.0 | nM | 307.44 | OC1Cc2ccccc2CC1N1CCC(c2ccccc2)CC1 | Homo sapiens | CHEMBL636849 | single protein format |
| CHEMBL20499 |  |
IC50 | = | 50.0 | nM | 364.49 | CC(=O)Nc1cccc2c1CC(N1CCC(c3ccccc3)CC1)C(O)C2 | Homo sapiens | CHEMBL636849 | single protein format |
| CHEMBL21271 |  |
IC50 | = | 50.0 | nM | 315.46 | CCC(=O)C1(c2ccccc2)CCN(C2CCCCC2O)CC1 | Homo sapiens | CHEMBL636849 | single protein format |
| CHEMBL207868 |  |
IC50 | = | 57.0 | nM | 351.49 | OC1CN(Cc2ccccc2)CCC1N1CCN(c2ccccc2)CC1 | Homo sapiens | CHEMBL870017 | cell-based format |
| CHEMBL207402 |  |
IC50 | = | 66.0 | nM | 430.39 | OC1CN(Cc2cccc(Br)c2)CCC1N1CCN(c2ccccc2)CC1 | Homo sapiens | CHEMBL870017 | cell-based format |
| CHEMBL21243 |  |
IC50 | = | 70.0 | nM | 301.47 | OC1CCCCC1N1CCC(CCCc2ccccc2)CC1 | Homo sapiens | CHEMBL636849 | single protein format |
| CHEMBL21722 |  |
IC50 | = | 90.0 | nM | 315.5 | CC(C)(C)[C@H]1CC[C@@H](N2CCC(c3ccccc3)CC2)[C@H](O)C1 | Homo sapiens | CHEMBL636849 | single protein format |
| CHEMBL20481 |  |
IC50 | = | 100.0 | nM | 274.41 | Cc1ccccc1N1CCN(C2CCCCC2O)CC1 | Homo sapiens | CHEMBL636849 | single protein format |
| CHEMBL377459 |  |
IC50 | = | 100.0 | nM | 261.37 | OC1CNCCC1N1CCN(c2ccccc2)CC1 | Homo sapiens | CHEMBL870017 | cell-based format |